Supplement·Interactions·Reviewed June 9, 2026
Quercetin interactions.
Quercetin has 51 documented interactions in the NutriStack database: 25 that need timing or caution and 26 that work synergistically. The full list, with what each pairing does, is below.
In short
Quercetin at a glance.
A quick, data-grounded summary. The full table is below.
Quercetin has 51 documented interactions in the NutriStack database: 25 that need timing or caution and 26 that work synergistically. The full list, with what each pairing does, is below.
Interactions
Everything that interacts with quercetin.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Amlodipine | Caution | Quercetin, a flavonoid found in grapefruit and many supplements, inhibits CYP3A4 and intestinal P-glycoprotein in vitro. Amlodipine is a CYP3A4... details → |
| Apixaban | Caution | Quercetin inhibits CYP3A4 and P-glycoprotein in vitro. Apixaban is metabolised by CYP3A4 and is a P-gp substrate, so high-dose quercetin supplements... |
| Bee Pollen | Caution | Bee pollen naturally contains quercetin and related flavonoids, so adding a quercetin supplement increases total flavonoid intake and overlaps with... |
| Cyclosporine | Caution | Quercetin may inhibit CYP3A4 or P-glycoprotein and could increase cyclosporine exposure and nephrotoxicity. |
| Dihexa | Caution | Quercetin has kinase and inflammatory signaling effects that complicate safety interpretation with dihexa. |
| Diltiazem | Caution | Quercetin pretreatment in rabbits roughly doubled the oral bioavailability of diltiazem by inhibiting CYP3A4 and intestinal P-glycoprotein. While... |
| Famciclovir | Caution | Famciclovir is an inactive prodrug that must be converted to its active form, penciclovir, largely by the enzyme aldehyde oxidase. Quercetin... |
| Felodipine | Caution | Quercetin inhibits CYP3A4 and P-glycoprotein in laboratory and some clinical studies. Because felodipine is a sensitive CYP3A4 substrate with low... |
| Fexofenadine | Caution | High-dose quercetin can raise fexofenadine exposure. In a controlled volunteer study, quercetin 500 mg three times daily for 7 days increased... details → |
| Fluconazole | Caution | Quercetin inhibits CYP3A4 and P-glycoprotein in vitro and has altered the pharmacokinetics of CYP3A4 substrates in animal models. Used alongside... |
| Glimepiride | Caution | Quercetin inhibits CYP2C9 in human studies. Glimepiride is metabolized primarily by CYP2C9. Concentrated quercetin supplements can raise glimepiride... details → |
| Glipizide | Caution | Quercetin is a flavonoid that inhibits CYP2C9 in human studies (it reduced diclofenac CYP2C9-mediated metabolism at 500 mg twice daily). Glipizide... details → |
| Glyburide | Caution | Quercetin inhibits CYP2C9 in human studies. Glyburide is metabolized by CYP2C9 (and CYP3A4) and is the longest-acting US sulfonylurea with the... details → |
| KPV | Caution | Quercetin also has anti-inflammatory claims and can confound symptom tracking. |
| Larazotide Acetate | Caution | Quercetin is often used for barrier or mast-cell claims and can confound symptom tracking. |
| Niacin (Prescription) | Caution | Prescription niacin causes prostaglandin-mediated cutaneous flushing (warmth, redness, itching), the most common reason for discontinuation.... |
| Pravastatin | Caution | Quercetin increased pravastatin exposure in a human study by inhibiting OATP1B1-mediated transport. The average increase was modest, but it could... details → |
| Roflumilast | Caution | Quercetin can inhibit some CYP enzymes and transporters in vitro, which could make roflumilast tolerability less predictable. |
| Silodosin | Caution | High-dose quercetin may inhibit CYP3A4 or P-glycoprotein and could increase silodosin exposure. |
| Solifenacin | Caution | High-dose quercetin may inhibit CYP3A4 or transporters and could increase solifenacin adverse effects. |
| Tacrolimus | Caution | Quercetin may inhibit CYP3A4 or P-glycoprotein and could increase tacrolimus exposure and toxicity. |
| Tolterodine | Caution | High-dose quercetin may inhibit CYP3A4 or transporters, potentially increasing tolterodine exposure in some patients. |
| Verapamil | Caution | In rabbits, quercetin roughly doubled both the Cmax and AUC of verapamil by inhibiting CYP3A4 and P-glycoprotein. Verapamil already has a narrow... |
| Warfarin | Caution | Quercetin and its metabolites strongly displace warfarin from human serum albumin, which can transiently raise free (active) warfarin... |
| Pterostilbene | Timing Sensitive | Quercetin inhibits several CYP450 enzymes and the efflux transporter P-glycoprotein. Co-administration could alter the metabolism and plasma levels... |
| Acyclovir | Synergy | Quercetin has demonstrated antiviral activity against HSV-1 in vitro and in animal models, primarily by interfering with viral attachment and... |
| Anthocyanins (Bilberry Extract) | Synergy | Quercetin and bilberry anthocyanins are both flavonoids with overlapping antioxidant and vascular-stabilizing actions, and they are frequently... |
| Bromelain | Synergy | Bromelain is traditionally co-formulated with quercetin to add anti-inflammatory activity, with the two compounds dampening inflammation through... |
| Curcumin Phytosome | Synergy | Both are potent anti-inflammatory polyphenols that modulate NF-κB and COX-2 through complementary mechanisms. |
| Desloratadine | Synergy | Quercetin is sometimes used for allergic symptom support and may overlap with desloratadine goals. |
| EGCG (Epigallocatechin Gallate) | Synergy | Quercetin inhibits the metabolism of EGCG, including COMT-mediated methylation and efflux transport, which can increase EGCG bioavailability and... |
| Elderberry | Synergy | Stacking elderberry with quercetin is a beneficial, complementary immune-support pairing rather than a risk. The two flavonoid sources hit different... |
| Enalapril | Synergy | Quercetin lowers blood pressure modestly (about 5-7 mm Hg systolic in stage 1 hypertensives) through endothelial improvement, AT1 receptor... details → |
| Fisetin | Synergy | Fisetin and quercetin are both flavonoid senolytic candidates with overlapping antioxidant and anti-inflammatory mechanisms, and they are frequently... |
| Fish Oil | Synergy | Quercetin and fish oil reduce inflammation through different pathways, giving an additive anti-inflammatory effect. |
| Ginger Extract | Synergy | Both are anti-inflammatory antioxidants that dampen overlapping inflammatory signaling, so combining them may provide additive antioxidant and... |
| Green Tea Extract | Synergy | Quercetin may raise plasma levels of green tea catechins by slowing their breakdown, and the two polyphenols provide additive antioxidant and... |
| Hesperidin | Synergy | Hesperidin and quercetin are both citrus/plant flavonoids with complementary antioxidant, anti-inflammatory and endothelium-supportive actions, and... |
| Lisinopril | Synergy | Quercetin lowers blood pressure modestly (about 5-7 mm Hg systolic in stage 1 hypertensives) through endothelial improvement, AT1 receptor... details → |
| Luteolin | Synergy | Luteolin and quercetin are both flavonoids with overlapping mast-cell-stabilizing, antihistaminic, and NF-kappaB-inhibiting anti-inflammatory... |
| NAC | Synergy | Quercetin and NAC provide complementary antioxidant support, with NAC replenishing glutathione and quercetin scavenging free radicals directly. |
| Oligonol (Lychee Polyphenol) | Synergy | Both are plant polyphenols with antioxidant and anti-inflammatory activity; combining them provides overlapping radical-scavenging and... |
| Olive Leaf Extract | Synergy | Olive leaf polyphenols and quercetin are complementary antioxidant and anti-inflammatory flavonoids that may also additively support healthy blood... |
| Resveratrol | Synergy | Quercetin inhibits resveratrol glucuronidation, increasing resveratrol bioavailability. Both are polyphenol antioxidants with complementary targets. |
| Rutin | Synergy | Rutin is the rhamnoglucoside of quercetin and is hydrolyzed by gut microbiota to release quercetin, so the two share overlapping antioxidant and... |
| Tangeretin | Synergy | Tangeretin and quercetin are plant flavonoids with overlapping antioxidant and anti-inflammatory actions and are commonly combined in citrus and... |
| Tart Cherry Extract | Synergy | Quercetin is a flavonoid present in cherries, and supplementing it alongside tart cherry polyphenols may give additive antioxidant and... |
| Turmeric/Curcumin | Synergy | Both are potent anti-inflammatory polyphenols that modulate NF-κB and COX-2 through complementary mechanisms. |
| Vitamin C | Synergy | Quercetin and vitamin C have synergistic antioxidant effects. Vitamin C helps regenerate oxidized quercetin. |
| Vitamin C Liposomal | Synergy | Quercetin and vitamin C have synergistic antioxidant effects. Vitamin C Liposomal helps regenerate oxidized quercetin. |
| Zinc | Synergy | Quercetin has shown zinc-ionophore activity in cell models, but clinical immune benefit from combining quercetin with zinc is not established. |
Go deeper
The full quercetin profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
FAQ
Common quercetin questions.
Quick answers drawn from the table above.
What interacts with Quercetin?
In the NutriStack database, Quercetin has 51 documented interactions with other supplements and medications. The most notable include Amlodipine, Apixaban, Bee Pollen, Cyclosporine, and Dihexa.
What works well with Quercetin?
Quercetin pairs synergistically with Acyclovir, Anthocyanins (Bilberry Extract), Bromelain, Curcumin Phytosome, and Desloratadine in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Quercetin with Amlodipine?
NutriStack classifies the Quercetin and Amlodipine pairing as caution: Quercetin, a flavonoid found in grapefruit and many supplements, inhibits CYP3A4 and intestinal P-glycoprotein in vitro. Amlodipine is a CYP3A4 substrate. However,... Moderate intake of quercetin supplements or grapefruit is generally acceptable with amlodipine. Avoid excessive grapefruit consumption (more than 1...
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