Supplement·Interactions·Reviewed June 9, 2026
Reishi interactions.
Reishi has 7 documented interactions in the NutriStack database: 1 that need timing or caution and 6 that work synergistically. The full list, with what each pairing does, is below.
Reishi at a glance.
A quick, data-grounded summary. The full table is below.
Reishi has 7 documented interactions in the NutriStack database: 1 that need timing or caution and 6 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with reishi.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Melatonin | Caution | Both have sedative properties. Reishi contains triterpenes that modulate GABAergic signaling. Combined with melatonin, may cause excessive drowsiness. |
| Acyclovir | Synergy | Ganoderma lucidum (Reishi) polysaccharides have antiviral activity against HSV-1 and HSV-2 in vitro, and a small clinical study reported faster... |
| Ashwagandha | Synergy | Both support immune modulation and stress adaptation through complementary mechanisms. |
| Chaga | Synergy | Chaga and reishi are both medicinal mushrooms providing beta-glucan polysaccharides, often stacked for complementary immune-modulating and... |
| Cordyceps | Synergy | Cordyceps and reishi are medicinal mushrooms commonly stacked for immune-modulating and adaptogenic support, providing overlapping beta-glucan... |
| Lion's Mane | Synergy | Reishi and lion's mane are frequently stacked in nootropic and wellness blends, pairing calming and immune support with neurotrophic cognitive... |
| Turkey Tail | Synergy | Turkey tail and reishi are both beta-glucan-rich medicinal mushrooms that modulate innate immune cell activity through complementary mechanisms,... |
The full reishi profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common reishi questions.
Quick answers drawn from the table above.
What interacts with Reishi?
In the NutriStack database, Reishi has 7 documented interactions with other supplements and medications. The most notable include Melatonin, Acyclovir, Ashwagandha, Chaga, and Cordyceps.
What works well with Reishi?
Reishi pairs synergistically with Acyclovir, Ashwagandha, Chaga, Cordyceps, and Lion's Mane in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Reishi with Melatonin?
NutriStack classifies the Reishi and Melatonin pairing as caution: Both have sedative properties. Reishi contains triterpenes that modulate GABAergic signaling. Combined with melatonin, may cause excessive drowsiness. If combining, start with low doses of both and use only at bedtime. Monitor for excessive sedation.
Check your whole stack
See how reishi fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.