Supplement·Interactions·Reviewed June 9, 2026
Resveratrol interactions.
Resveratrol has 22 documented interactions in the NutriStack database: 7 that need timing or caution and 15 that work synergistically. The full list, with what each pairing does, is below.
Resveratrol at a glance.
A quick, data-grounded summary. The full table is below.
Resveratrol has 22 documented interactions in the NutriStack database: 7 that need timing or caution and 15 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with resveratrol.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Celecoxib | Caution | Resveratrol may increase celecoxib exposure and also has antiplatelet effects, creating a plausible safety concern. A human pharmacokinetic study... |
| Dihexa | Caution | Resveratrol affects cell-signaling pathways and may confound attempts to interpret an unapproved c-Met-active compound. |
| Diltiazem | Caution | Resveratrol is a mechanism-based inhibitor of CYP3A4 and a P-glycoprotein blocker. In rats, oral resveratrol increased diltiazem AUC and Cmax... |
| Fluconazole | Caution | Resveratrol inhibits CYP3A4 in vitro and in animal pharmacokinetic studies, where it has raised plasma exposure of CYP3A4 substrates such as... |
| Nifedipine | Caution | Resveratrol inhibits CYP3A4 and intestinal P-glycoprotein, and in rats it raised nicardipine AUC 111-126% via both mechanisms. Because nifedipine... |
| Turmeric/Curcumin | Caution | Both polyphenols have antiplatelet activity, so combining them may additively reduce platelet aggregation and increase bleeding tendency. |
| Warfarin | Caution | Resveratrol inhibits CYP2C9, the main enzyme that clears the more potent S-enantiomer of warfarin, and also inhibits BCRP-mediated efflux. In animal... |
| Ellagic Acid | Synergy | Resveratrol and ellagic acid are both polyphenols with antioxidant and Nrf2-supporting activity, and may be used together for general... |
| Evening Primrose Oil | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Resveratrol. |
| Fisetin | Synergy | Both are polyphenols studied in the healthy-aging space with overlapping antioxidant and stress-response signaling, and both are best absorbed with... |
| Fish Oil | Synergy | Resveratrol is lipophilic and absorbs better with dietary fat. Both have anti-inflammatory and cardioprotective properties. |
| Fish Oil Triple Strength | Synergy | Resveratrol is lipophilic and absorbs better with dietary fat. Both have anti-inflammatory and cardioprotective properties. |
| Flaxseed Oil | Synergy | Flaxseed Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Resveratrol. |
| Krill Oil | Synergy | Resveratrol is lipophilic and absorbs better with dietary fat. Both have anti-inflammatory and cardioprotective properties. |
| MCT Oil | Synergy | MCT Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Resveratrol. |
| Metoprolol | Synergy | High-dose resveratrol (≥150 mg/day) modestly reduces systolic blood pressure and improves endothelial function. Combined with metoprolol, the net... details → |
| Nicotinamide Riboside | Synergy | NR raises cellular NAD+ levels, and resveratrol is a putative SIRT1 activator. Because sirtuins consume NAD+ as a cosubstrate, the two are... |
| NMN | Synergy | NMN supports NAD+-pathway markers, while resveratrol has sirtuin-related preclinical research; direct human evidence for the combination is absent. |
| Pterostilbene | Synergy | Pterostilbene is the dimethylated analog of resveratrol with markedly higher oral bioavailability and a longer half-life. The two share overlapping... |
| Quercetin | Synergy | Quercetin inhibits resveratrol glucuronidation, increasing resveratrol bioavailability. Both are polyphenol antioxidants with complementary targets. |
| Spermidine | Synergy | Both spermidine and resveratrol are studied as autophagy-inducing caloric-restriction mimetics, acting through partly convergent deacetylation... |
| Urolithin A | Synergy | Both are studied within the polyphenol/longevity space and influence mitochondrial biogenesis pathways, though by different mechanisms. |
The full resveratrol profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common resveratrol questions.
Quick answers drawn from the table above.
What interacts with Resveratrol?
In the NutriStack database, Resveratrol has 22 documented interactions with other supplements and medications. The most notable include Celecoxib, Dihexa, Diltiazem, Fluconazole, and Nifedipine.
What works well with Resveratrol?
Resveratrol pairs synergistically with Ellagic Acid, Evening Primrose Oil, Fisetin, Fish Oil, and Fish Oil Triple Strength in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Resveratrol with Celecoxib?
NutriStack classifies the Resveratrol and Celecoxib pairing as caution: Resveratrol may increase celecoxib exposure and also has antiplatelet effects, creating a plausible safety concern. A human pharmacokinetic study found celecoxib... Use caution with resveratrol supplements while taking celecoxib, especially at high doses. Watch for celecoxib adverse effects such as stomach pain,...
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