Supplement·Interactions·Reviewed June 9, 2026
Rhodiola Rosea interactions.
Rhodiola Rosea has 24 documented interactions in the NutriStack database: 2 to avoid or watch closely, 15 that need timing or caution, and 7 that work synergistically. The full list, with what each pairing does, is below.
Rhodiola Rosea at a glance.
A quick, data-grounded summary. The full table is below.
Rhodiola Rosea has 24 documented interactions in the NutriStack database: 2 to avoid or watch closely, 15 that need timing or caution, and 7 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with rhodiola rosea.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Phenelzine | Conflict | Rhodiola may have stimulant and monoaminergic effects, which are risky during nonselective MAO inhibition. |
| Tranylcypromine | Conflict | Rhodiola may have stimulant or monoaminergic effects that are poorly predictable during nonselective MAO inhibition. |
| 5-HTP | Caution | Rhodiola has preclinical monoamine effects, while 5-HTP increases serotonin synthesis. Combined use carries a theoretical serotonin-excess risk, but... |
| Caffeine | Caution | Both can feel stimulating in some users and may increase anxiety or insomnia. |
| Citalopram | Caution | Citalopram is serotonergic. Rhodiola has preclinical monoamine and MAO-related findings, but direct human evidence for serotonin syndrome with... |
| Crocin (Saffron Extract) | Caution | Rhodiola has mild monoamine-modulating, MAO-inhibiting activity and saffron is serotonergic, so combining them adds to overall monoaminergic tone. |
| Escitalopram | Caution | Escitalopram is serotonergic. Rhodiola has preclinical monoamine and MAO-related findings, but direct human evidence for serotonin syndrome with... |
| Fluoxetine | Caution | Fluoxetine is serotonergic. Rhodiola has preclinical monoamine and MAO-related findings, but direct human evidence for serotonin syndrome with... |
| Mucuna Pruriens | Caution | Both can feel activating and may worsen anxiety, insomnia, palpitations, or agitation. |
| Panax Ginseng | Caution | Panax ginseng and Rhodiola rosea are both stimulating adaptogens often combined for fatigue and stress, but stacking them may overstimulate and... |
| Paroxetine | Caution | Paroxetine is serotonergic. Rhodiola has preclinical monoamine and MAO-related findings, but direct human evidence for serotonin syndrome with... |
| Rasagiline | Caution | Rhodiola may have stimulant or monoaminergic effects that could add to MAO-B inhibition. |
| Selegiline | Caution | Rhodiola is promoted for stimulant and monoaminergic effects. Combining it with MAO-B inhibition may increase agitation, insomnia, blood pressure,... |
| Semax | Caution | Rhodiola can be stimulating and may add to semax-related agitation or insomnia. |
| Sertraline | Caution | Sertraline is serotonergic. Rhodiola has preclinical monoamine and MAO-related findings, but direct human evidence for serotonin syndrome with... |
| St. John's Wort | Caution | Rhodiola and St. John's Wort both have CNS-active and possible serotonergic effects. Human interaction evidence is limited, but combining them can... |
| Theacrine | Caution | Rhodiola can feel activating and may add to theacrine-related stimulation. |
| Ashwagandha | Synergy | Both are adaptogens studied for perceived-stress or fatigue markers, but direct combination evidence is limited. |
| Bacopa Monnieri | Synergy | Both are adaptogenic and cognition-supporting herbs, and combining them may give additive benefits for stress resilience and mental performance. |
| Cordyceps | Synergy | Both adaptogens enhance physical performance and energy through complementary mechanisms. |
| L-Theanine | Synergy | L-theanine takes the edge off rhodiola's mild stimulating effect, supporting calm, focused stress resilience. |
| L-Tyrosine | Synergy | Rhodiola inhibits MAO and COMT, reducing dopamine/norepinephrine breakdown. L-tyrosine provides the precursor. Together they increase catecholamine... |
| Magnesium Glycinate | Synergy | Magnesium supports the stress response and nervous system relaxation, complementing rhodiola's adaptogenic effect on stress and fatigue. |
| Schisandra | Synergy | Schisandra and Rhodiola are both adaptogens that modulate the stress response and reduce fatigue, with traditional and clinical use of the... |
The full rhodiola rosea profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common rhodiola rosea questions.
Quick answers drawn from the table above.
What interacts with Rhodiola Rosea?
In the NutriStack database, Rhodiola Rosea has 24 documented interactions with other supplements and medications. The most notable include Phenelzine, Tranylcypromine, 5-HTP, Caffeine, and Citalopram.
What should you not take with Rhodiola Rosea?
Rhodiola Rosea is flagged against 2 substances in the database, including Phenelzine and Tranylcypromine. Review these with a clinician before combining, especially alongside prescription medications.
What works well with Rhodiola Rosea?
Rhodiola Rosea pairs synergistically with Ashwagandha, Bacopa Monnieri, Cordyceps, L-Theanine, and L-Tyrosine in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Rhodiola Rosea with Phenelzine?
NutriStack classifies the Rhodiola Rosea and Phenelzine pairing as conflict: Rhodiola may have stimulant and monoaminergic effects, which are risky during nonselective MAO inhibition. Avoid rhodiola while taking phenelzine.
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