Supplement·Interactions·Reviewed June 9, 2026
Saccharomyces Boulardii interactions.
Saccharomyces Boulardii has 17 documented interactions in the NutriStack database: 1 to avoid or watch closely, 2 that need timing or caution, and 14 that work synergistically. The full list, with what each pairing does, is below.
Saccharomyces Boulardii at a glance.
A quick, data-grounded summary. The full table is below.
Saccharomyces Boulardii has 17 documented interactions in the NutriStack database: 1 to avoid or watch closely, 2 that need timing or caution, and 14 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with saccharomyces boulardii.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Fluconazole | Conflict | Saccharomyces boulardii is itself a yeast (a non-pathogenic strain of S. cerevisiae). Fluconazole has variable activity against Saccharomyces... |
| Digestive Enzymes | Timing Sensitive | Both support gut health but work best at different times. Digestive enzymes work with meals; saccharomyces boulardii prefer an empty stomach or... |
| Iron | Timing Sensitive | Iron supplements can disrupt gut microbiome composition. However, certain probiotic strains may actually enhance iron absorption. |
| Amoxicillin | Synergy | Saccharomyces boulardii reduces antibiotic-associated diarrhea during amoxicillin therapy and is unaffected by the antibiotic because it is a yeast.... details → |
| Amoxicillin-Clavulanate | Synergy | Saccharomyces boulardii reduces the elevated antibiotic-associated diarrhea risk of amoxicillin-clavulanate. Because it is a yeast, it is unaffected... details → |
| Azithromycin | Synergy | Saccharomyces boulardii reduces antibiotic-associated diarrhea during azithromycin therapy and is unaffected by the antibiotic because it is a yeast. details → |
| Cephalexin | Synergy | Saccharomyces boulardii reduces antibiotic-associated diarrhea during cephalexin therapy and is unaffected by the antibiotic because it is a yeast. details → |
| Ciprofloxacin | Synergy | Saccharomyces boulardii is a yeast probiotic with strong evidence for preventing antibiotic-associated diarrhea and C. difficile infection. Because... details → |
| Clarithromycin | Synergy | Saccharomyces boulardii reduces antibiotic-associated diarrhea during clarithromycin therapy and is unaffected by the antibiotic because it is a... details → |
| Clindamycin | Synergy | Clindamycin carries one of the highest risks of C. difficile-associated colitis among commonly used antibiotics. Saccharomyces boulardii has strong... details → |
| D-Mannose | Synergy | D-Mannose and the probiotic yeast Saccharomyces boulardii have been combined as a non-antibiotic UTI prophylaxis strategy. A randomized pilot study... |
| L-Glutamine | Synergy | L-glutamine and the probiotic yeast Saccharomyces boulardii are often combined for gut barrier and digestive support, acting through complementary... |
| Mesalamine | Synergy | Saccharomyces boulardii has limited human evidence as an add-on during mesalamine maintenance for mild-to-moderate ulcerative colitis flare... |
| Metronidazole | Synergy | Saccharomyces boulardii is a yeast probiotic with strong evidence for preventing antibiotic-associated diarrhea, and it is unaffected by... details → |
| Omeprazole | Synergy | Saccharomyces boulardii is a non-pathogenic yeast probiotic with strong evidence for preventing antibiotic-associated and C. difficile-associated... details → |
| Probiotics | Synergy | Adding the probiotic yeast Saccharomyces boulardii to bacterial probiotics broadens coverage and is particularly effective for preventing... |
| Vitamin D3 | Synergy | Vitamin D supports the gut immune barrier. Saccharomyces Boulardii modulate the microbiome. Together they support gut-immune axis health. |
The full saccharomyces boulardii profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common saccharomyces boulardii questions.
Quick answers drawn from the table above.
What interacts with Saccharomyces Boulardii?
In the NutriStack database, Saccharomyces Boulardii has 17 documented interactions with other supplements and medications. The most notable include Fluconazole, Digestive Enzymes, Iron, Amoxicillin, and Amoxicillin-Clavulanate.
What should you not take with Saccharomyces Boulardii?
Saccharomyces Boulardii is flagged against 1 substance in the database, including Fluconazole. Review these with a clinician before combining, especially alongside prescription medications.
What works well with Saccharomyces Boulardii?
Saccharomyces Boulardii pairs synergistically with Amoxicillin, Amoxicillin-Clavulanate, Azithromycin, Cephalexin, and Ciprofloxacin in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Saccharomyces Boulardii with Fluconazole?
NutriStack classifies the Saccharomyces Boulardii and Fluconazole pairing as conflict: Saccharomyces boulardii is itself a yeast (a non-pathogenic strain of S. cerevisiae). Fluconazole has variable activity against Saccharomyces species and may suppress... Hold Saccharomyces boulardii during your fluconazole course. Resume a few days after finishing fluconazole if you still want probiotic support....
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