Supplement·Interactions·Reviewed June 9, 2026
Schisandra interactions.
Schisandra has 10 documented interactions in the NutriStack database: 1 to avoid or watch closely, 5 that need timing or caution, and 4 that work synergistically. The full list, with what each pairing does, is below.
Schisandra at a glance.
A quick, data-grounded summary. The full table is below.
Schisandra has 10 documented interactions in the NutriStack database: 1 to avoid or watch closely, 5 that need timing or caution, and 4 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with schisandra.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Tacrolimus/Cyclosporine | Contraindicated | Schisandra increased tacrolimus AUC by 164% and Cmax by 227%. Potentially fatal in transplant patients. |
| Budesonide Inhaled | Caution | Schisandra extract inhibits CYP3A in human pharmacokinetic studies. Budesonide is normally cleared extensively by CYP3A, so inhibition can raise... details → |
| Dexamethasone | Caution | Schisandra extract can inhibit CYP3A in humans, and dexamethasone exposure rises markedly when CYP3A4 is inhibited. Adding Schisandra could increase... details → |
| Fluticasone Inhaled | Caution | Schisandra has human evidence of CYP3A inhibition, and fluticasone is highly dependent on CYP3A metabolism. Strong CYP3A inhibition has caused... details → |
| Fluticasone Nasal | Caution | Nasal fluticasone usually has low systemic exposure, but CYP3A inhibition can still increase steroid exposure in susceptible patients. Schisandra... details → |
| Methylprednisolone | Caution | Schisandra extract has human evidence of inhibiting CYP3A activity, and methylprednisolone exposure is highly sensitive to CYP3A inhibition.... details → |
| Ashwagandha | Synergy | Schisandra and ashwagandha are both adaptogens that help regulate the stress axis and lower perceived stress, with complementary calming and... |
| Milk Thistle | Synergy | Schisandra lignans and milk thistle silymarin both support hepatocyte protection and antioxidant defense, giving complementary hepatoprotective... |
| NAC | Synergy | Schisandra and NAC both raise hepatic glutathione and antioxidant capacity, providing complementary protection against oxidative liver stress. |
| Rhodiola Rosea | Synergy | Schisandra and Rhodiola are both adaptogens that modulate the stress response and reduce fatigue, with traditional and clinical use of the... |
The full schisandra profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common schisandra questions.
Quick answers drawn from the table above.
What interacts with Schisandra?
In the NutriStack database, Schisandra has 10 documented interactions with other supplements and medications. The most notable include Tacrolimus/Cyclosporine, Budesonide Inhaled, Dexamethasone, Fluticasone Inhaled, and Fluticasone Nasal.
What should you not take with Schisandra?
Schisandra is flagged against 1 substance in the database, including Tacrolimus/Cyclosporine. Review these with a clinician before combining, especially alongside prescription medications.
What works well with Schisandra?
Schisandra pairs synergistically with Ashwagandha, Milk Thistle, NAC, and Rhodiola Rosea in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Schisandra with Tacrolimus/Cyclosporine?
NutriStack classifies the Schisandra and Tacrolimus/Cyclosporine pairing as contraindicated: Schisandra increased tacrolimus AUC by 164% and Cmax by 227%. Potentially fatal in transplant patients. Do NOT combine. Schisandra dramatically increases immunosuppressant levels.
Check your whole stack
See how schisandra fits your routine.
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