Supplement·Interactions·Reviewed June 9, 2026
Serrapeptase interactions.
Serrapeptase has 5 documented interactions in the NutriStack database: 4 that need timing or caution and 1 that work synergistically. The full list, with what each pairing does, is below.
Serrapeptase at a glance.
A quick, data-grounded summary. The full table is below.
Serrapeptase has 5 documented interactions in the NutriStack database: 4 that need timing or caution and 1 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with serrapeptase.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Fish Oil | Caution | Fish oil has mild antiplatelet activity that can add to serrapeptase's fibrinolytic effect, modestly increasing the chance of bruising or prolonged... |
| Ginkgo Biloba | Caution | Ginkgo inhibits platelet-activating factor and serrapeptase is fibrinolytic, so combining them can additively impair hemostasis and increase the... |
| Nattokinase | Caution | Combining these two fibrinolytic enzymes produces additive breakdown of fibrin and a higher risk of bruising, prolonged bleeding, and (rarely)... |
| Turmeric/Curcumin | Caution | Serrapeptase has fibrinolytic activity and curcumin has antiplatelet activity, so the combination can additively reduce clotting and increase... |
| Bromelain | Synergy | Serrapeptase and bromelain are commonly combined as systemic proteolytic enzymes and appear to act in a complementary way to reduce post-surgical... |
The full serrapeptase profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common serrapeptase questions.
Quick answers drawn from the table above.
What interacts with Serrapeptase?
In the NutriStack database, Serrapeptase has 5 documented interactions with other supplements and medications. The most notable include Fish Oil, Ginkgo Biloba, Nattokinase, Turmeric/Curcumin, and Bromelain.
What works well with Serrapeptase?
Serrapeptase pairs synergistically with Bromelain in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Serrapeptase with Fish Oil?
NutriStack classifies the Serrapeptase and Fish Oil pairing as caution: Fish oil has mild antiplatelet activity that can add to serrapeptase's fibrinolytic effect, modestly increasing the chance of bruising or prolonged bleeding, mainly at... The combination is generally tolerated, but use caution with high-dose fish oil. Discontinue both before surgery and consult a clinician if also...
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