Supplement·Interactions·Reviewed June 9, 2026
Sulforaphane interactions.
Sulforaphane has 5 documented interactions in the NutriStack database: 5 that work synergistically. The full list, with what each pairing does, is below.
Sulforaphane at a glance.
A quick, data-grounded summary. The full table is below.
Sulforaphane has 5 documented interactions in the NutriStack database: 5 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with sulforaphane.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| DIM | Synergy | Both are cruciferous-derived compounds that favorably shift estrogen metabolism and induce phase I and phase II detoxification, giving complementary... |
| Milk Thistle | Synergy | Sulforaphane and silymarin (the active fraction of milk thistle) both activate Nrf2-driven cytoprotective and antioxidant defenses in the liver,... |
| NAC | Synergy | Both compounds raise intracellular glutathione: sulforaphane induces the enzymes that synthesize glutathione while NAC supplies the rate-limiting... |
| Selenium | Synergy | Sulforaphane and selenium act on the same antioxidant axis: sulforaphane induces the genes for selenium-dependent enzymes (thioredoxin reductase 1... |
| Vitamin C | Synergy | When sulforaphane is taken in precursor (glucoraphanin) form, vitamin C can improve its conversion to the active molecule by supporting the... |
The full sulforaphane profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common sulforaphane questions.
Quick answers drawn from the table above.
What interacts with Sulforaphane?
In the NutriStack database, Sulforaphane has 5 documented interactions with other supplements and medications. The most notable include DIM, Milk Thistle, NAC, Selenium, and Vitamin C.
What works well with Sulforaphane?
Sulforaphane pairs synergistically with DIM, Milk Thistle, NAC, Selenium, and Vitamin C in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Sulforaphane with DIM?
NutriStack classifies the Sulforaphane and DIM pairing as synergy: Both are cruciferous-derived compounds that favorably shift estrogen metabolism and induce phase I and phase II detoxification, giving complementary support to hormone... Reasonable to combine for estrogen metabolism or detoxification goals. No timing separation is required.
Check your whole stack
See how sulforaphane fits your routine.
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