Supplement·Interactions·Reviewed June 9, 2026
Tribulus Terrestris interactions.
Tribulus Terrestris has 9 documented interactions in the NutriStack database: 3 that need timing or caution and 6 that work synergistically. The full list, with what each pairing does, is below.
Tribulus Terrestris at a glance.
A quick, data-grounded summary. The full table is below.
Tribulus Terrestris has 9 documented interactions in the NutriStack database: 3 that need timing or caution and 6 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with tribulus terrestris.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Atorvastatin | Caution | A case report described rhabdomyolysis after Tribulus terrestris was started in a patient taking long-term atorvastatin. Causality is not proven,... |
| Statins | Caution | Tribulus terrestris is a moderate CYP3A4 inhibitor. Documented rhabdomyolysis in patient on atorvastatin who started tribulus. |
| Testosterone | Caution | Tribulus terrestris is widely marketed as a testosterone booster, but systematic reviews and meta-analyses generally find no consistent effect on... details → |
| Ashwagandha | Synergy | Ashwagandha adds adaptogenic, stress-lowering and modest androgen-supportive effects that complement Tribulus, with additive potential for male... |
| Boron | Synergy | Boron can raise free testosterone by lowering sex hormone binding globulin and reducing conversion of testosterone to estradiol, a mechanism that... |
| Fenugreek | Synergy | Tribulus and fenugreek are both used in male vitality and libido formulas, with complementary effects on sexual function and, for fenugreek, some... |
| Maca Root | Synergy | Combining Tribulus and Maca pairs two libido and sexual function botanicals that act through largely separate pathways, giving complementary support... |
| Tongkat Ali | Synergy | Tribulus and Tongkat Ali are both used to support libido and male sexual function, with complementary traditional and clinical use for that goal. |
| Zinc | Synergy | Zinc is an essential cofactor for testosterone synthesis, so correcting low zinc status complements the libido-supporting use of Tribulus in male... |
The full tribulus terrestris profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common tribulus terrestris questions.
Quick answers drawn from the table above.
What interacts with Tribulus Terrestris?
In the NutriStack database, Tribulus Terrestris has 9 documented interactions with other supplements and medications. The most notable include Atorvastatin, Statins, Testosterone, Ashwagandha, and Boron.
What works well with Tribulus Terrestris?
Tribulus Terrestris pairs synergistically with Ashwagandha, Boron, Fenugreek, Maca Root, and Tongkat Ali in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Tribulus Terrestris with Atorvastatin?
NutriStack classifies the Tribulus Terrestris and Atorvastatin pairing as caution: A case report described rhabdomyolysis after Tribulus terrestris was started in a patient taking long-term atorvastatin. Causality is not proven, but the outcome is... Avoid adding Tribulus terrestris to atorvastatin without clinician review. Stop the supplement and seek care urgently for severe muscle pain,...
Check your whole stack
See how tribulus terrestris fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.