Supplement·Interactions·Reviewed June 9, 2026
Trimethylglycine interactions.
Trimethylglycine has 5 documented interactions in the NutriStack database: 1 that need timing or caution and 4 that work synergistically. The full list, with what each pairing does, is below.
Trimethylglycine at a glance.
A quick, data-grounded summary. The full table is below.
Trimethylglycine has 5 documented interactions in the NutriStack database: 1 that need timing or caution and 4 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with trimethylglycine.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Fish Oil | Caution | High-dose betaine can modestly raise LDL cholesterol and triglycerides in some people. Pairing with omega-3 fish oil, which tends to lower... |
| Creatine | Synergy | Endogenous creatine synthesis consumes a large share of the body's SAMe-derived methyl groups. Supplementing creatine reduces methylation demand,... |
| Methylfolate | Synergy | TMG and methylfolate act on parallel homocysteine remethylation routes: TMG drives the folate-independent BHMT pathway while methylfolate (with B12)... |
| Vitamin B12 | Synergy | Adequate B12 ensures the methionine synthase pathway functions, so that methyl groups from both folate and betaine are used efficiently and... |
| Zinc | Synergy | Zinc is the catalytic metal cofactor for betaine-homocysteine methyltransferase (BHMT), the enzyme through which TMG donates its methyl group to... |
The full trimethylglycine profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common trimethylglycine questions.
Quick answers drawn from the table above.
What interacts with Trimethylglycine?
In the NutriStack database, Trimethylglycine has 5 documented interactions with other supplements and medications. The most notable include Fish Oil, Creatine, Methylfolate, Vitamin B12, and Zinc.
What works well with Trimethylglycine?
Trimethylglycine pairs synergistically with Creatine, Methylfolate, Vitamin B12, and Zinc in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Trimethylglycine with Fish Oil?
NutriStack classifies the Trimethylglycine and Fish Oil pairing as caution: High-dose betaine can modestly raise LDL cholesterol and triglycerides in some people. Pairing with omega-3 fish oil, which tends to lower triglycerides, may help... If using higher TMG doses, check a lipid panel periodically. Fish oil is a reasonable co-supplement for those concerned about triglycerides, but it...
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