Supplement·Interactions·Reviewed June 9, 2026
Turmeric/Curcumin interactions.
Turmeric/Curcumin has 35 documented interactions in the NutriStack database: 18 that need timing or caution and 17 that work synergistically. The full list, with what each pairing does, is below.
Turmeric/Curcumin at a glance.
A quick, data-grounded summary. The full table is below.
Turmeric/Curcumin has 35 documented interactions in the NutriStack database: 18 that need timing or caution and 17 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with turmeric/curcumin.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Amlodipine | Caution | Curcumin inhibits CYP3A4 and intestinal P-glycoprotein, both of which contribute to amlodipine clearance and absorption. In a rat pharmacokinetic... |
| Apixaban | Caution | Curcumin has antiplatelet properties that may increase bleeding risk when combined with apixaban. While no direct pharmacokinetic interaction has... |
| Aspirin Low-Dose | Caution | Turmeric/curcumin supplements may add antiplatelet effects to low-dose aspirin. Culinary turmeric is usually a minor exposure, but concentrated... |
| Celecoxib | Caution | Both celecoxib and curcumin inhibit COX-2. Combined use may provide additive anti-inflammatory effects but also increases the risk of GI and... |
| Chondroitin | Caution | Both may have mild antiplatelet effects, so combining them could modestly increase bleeding tendency, particularly in people also taking... |
| Clopidogrel | Caution | Curcumin inhibits platelet aggregation through thromboxane A2 synthesis inhibition and GPVI-mediated platelet activation blockade in laboratory... details → |
| Diclofenac | Caution | Concentrated turmeric/curcumin may add antiplatelet effects to diclofenac's GI bleeding risk. Diclofenac can cause NSAID-related erosions or ulcers,... |
| Fish Oil | Caution | Both have blood-thinning properties. High doses of both together may increase bleeding risk. details → |
| Fish Oil Triple Strength | Caution | Both have blood-thinning properties. High doses of both together may increase bleeding risk. details → |
| Fluconazole | Caution | Curcumin inhibits CYP3A4 and P-glycoprotein in vitro and has altered the pharmacokinetics of CYP3A4 substrates such as amlodipine and budesonide in... |
| Ibuprofen | Caution | Concentrated turmeric/curcumin may add antiplatelet effects to ibuprofen's bleeding risk. Ibuprofen also increases upper GI injury risk, especially... |
| Krill Oil | Caution | Both have blood-thinning properties. High doses of both together may increase bleeding risk. details → |
| Meloxicam | Caution | Concentrated turmeric/curcumin may add antiplatelet effects to meloxicam's bleeding risk. Meloxicam can still injure the GI tract with daily use,... |
| Naproxen | Caution | Concentrated turmeric/curcumin may add antiplatelet activity to naproxen's GI bleeding risk. Naproxen has a relatively strong association with upper... |
| Resveratrol | Caution | Both polyphenols have antiplatelet activity, so combining them may additively reduce platelet aggregation and increase bleeding tendency. |
| Rivaroxaban | Caution | Curcumin has antiplatelet properties that may increase bleeding risk when combined with rivaroxaban. The additive effect on hemostasis through... |
| Serrapeptase | Caution | Serrapeptase has fibrinolytic activity and curcumin has antiplatelet activity, so the combination can additively reduce clotting and increase... |
| Warfarin | Caution | Curcumin may inhibit platelet aggregation and has shown anticoagulant properties in vitro and in animal studies. When combined with warfarin, there... details → |
| Artemisinin | Synergy | Curcumin has been studied as a complementary partner to artemisinin, with preclinical data suggesting added antiparasitic and pro-oxidant effects. |
| Berberine | Synergy | Curcumin and berberine share overlapping anti-inflammatory pathways (NF-kB inhibition) and both have glucose-lowering effects. The combination may... |
| Black Seed Oil | Synergy | Both are anti-inflammatory and antioxidant agents that have shown complementary metabolic benefits when studied together, including improved... |
| Boswellia | Synergy | Combined use produces greater anti-inflammatory and joint symptom relief than either agent alone in osteoarthritis studies. |
| Bromelain | Synergy | Bromelain is widely co-formulated with curcumin to add its own proteolytic anti-inflammatory effect, increasing the net anti-inflammatory action of... |
| Cat's Claw | Synergy | Combined use broadens anti-inflammatory coverage by suppressing NF-kB driven cytokine production through complementary pathways, supporting joint... |
| Digestive Enzymes | Synergy | Digestive enzymes can improve curcumin absorption by breaking down the food matrix. Curcumin also stimulates bile flow which aids fat digestion. |
| Evening Primrose Oil | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Turmeric/Curcumin. |
| Flaxseed Oil | Synergy | Flaxseed Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Turmeric/Curcumin. |
| Ginger Extract | Synergy | Combined use offers complementary anti-inflammatory and antinausea support, with some additive antiplatelet effect to keep in mind. |
| MCT Oil | Synergy | MCT Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Turmeric/Curcumin. |
| Mesalamine | Synergy | Curcumin has randomized-trial and meta-analysis evidence as an adjunct to mesalamine in mild-to-moderate ulcerative colitis. Higher-dose curcumin... details → |
| Milk Thistle | Synergy | Both are hepatoprotective compounds that support liver health through complementary antioxidant and anti-inflammatory mechanisms. |
| NAC | Synergy | Both support liver detoxification and reduce oxidative stress. Curcumin is a direct antioxidant; NAC supports glutathione production. |
| Omeprazole | Synergy | A 2023 randomized, double-blind trial in patients with functional dyspepsia found curcumin alone, omeprazole alone, and the combination produced... details → |
| Quercetin | Synergy | Both are potent anti-inflammatory polyphenols that modulate NF-κB and COX-2 through complementary mechanisms. |
| Sulfasalazine | Synergy | Curcumin has been studied as an add-on to sulfasalazine or mesalamine for ulcerative colitis remission maintenance. In a randomized trial, adding... details → |
The full turmeric/curcumin profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common turmeric/curcumin questions.
Quick answers drawn from the table above.
What interacts with Turmeric/Curcumin?
In the NutriStack database, Turmeric/Curcumin has 35 documented interactions with other supplements and medications. The most notable include Amlodipine, Apixaban, Aspirin Low-Dose, Celecoxib, and Chondroitin.
What works well with Turmeric/Curcumin?
Turmeric/Curcumin pairs synergistically with Artemisinin, Berberine, Black Seed Oil, Boswellia, and Bromelain in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Turmeric/Curcumin with Amlodipine?
NutriStack classifies the Turmeric/Curcumin and Amlodipine pairing as caution: Curcumin inhibits CYP3A4 and intestinal P-glycoprotein, both of which contribute to amlodipine clearance and absorption. In a rat pharmacokinetic study, curcumin... If you take amlodipine, keep turmeric to culinary amounts and avoid high-dose curcumin supplements unless your prescriber agrees. If you do use a...
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