Supplement·Interactions·Reviewed June 9, 2026
Valerian Root interactions.
Valerian Root has 16 documented interactions in the NutriStack database: 15 that need timing or caution and 1 that work synergistically. The full list, with what each pairing does, is below.
Valerian Root at a glance.
A quick, data-grounded summary. The full table is below.
Valerian Root has 16 documented interactions in the NutriStack database: 15 that need timing or caution and 1 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with valerian root.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alprazolam | Caution | Valerian root has GABAergic sedative properties that can potentiate alprazolam's CNS depressant effects. The combination may cause excessive... details → |
| Cannabis (THC-Dominant) | Caution | Valerian and THC-dominant cannabis both have sedative properties, so combining them can cause additive central nervous system depression and... |
| Clonazepam | Caution | Both clonazepam and valerian act on GABA-A receptors. Combined use causes additive CNS depression, excessive sedation, and respiratory depression... details → |
| Diazepam | Caution | Both diazepam and valerian enhance GABA-A receptor activity. Combined use creates additive CNS depression and excessive sedation. details → |
| Diphenhydramine | Caution | Diphenhydramine can cause meaningful drowsiness, slowed reaction time, anticholinergic confusion, and driving impairment. Valerian root is commonly... |
| GABA | Caution | Additive sedation and CNS depression, which can cause excessive drowsiness, especially if combined with alcohol or other sedatives. details → |
| Hydrocodone | Caution | Hydrocodone can cause sedation and respiratory depression, and valerian root may add CNS-depressant effects through GABAergic activity. Direct... |
| Ketamine | Caution | Valerian root has sedative-hypnotic activity that can add to ketamine's central depressant and dissociative effects, increasing drowsiness,... details → |
| Lorazepam | Caution | Valerian root enhances GABAergic activity, which adds to lorazepam's CNS depressant effects. This combination can lead to excessive sedation,... details → |
| Melatonin | Caution | Valerian root and melatonin both promote sleep through different mechanisms, so combining them can produce additive sedation and next-morning... details → |
| Passionflower | Caution | Both herbs are sedative and GABAergic, so combining them produces additive drowsiness and CNS depression, an effect used in some combination sleep... details → |
| Pregabalin | Caution | Both pregabalin and valerian have sedating properties. Pregabalin binds alpha-2-delta calcium channel subunits; valerian modulates GABA-A. Combined... details → |
| Quetiapine | Caution | Valerian root has GABAergic and sedative properties that can produce additive CNS depression when combined with quetiapine. The combination may... |
| Trazodone | Caution | Valerian root acts on GABA-A receptors via valerenic acid, producing sedation. Trazodone is itself a strongly sedating antidepressant commonly used... |
| Zolpidem | Caution | Both zolpidem and valerian act on GABA-A receptors. Combined use can cause excessive CNS depression, over-sedation, and next-day impairment. details → |
| L-Theanine | Synergy | Valerian root provides GABAergic sedation while L-theanine promotes calm without strong sedation, giving a complementary relaxation effect that is... |
The full valerian root profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common valerian root questions.
Quick answers drawn from the table above.
What interacts with Valerian Root?
In the NutriStack database, Valerian Root has 16 documented interactions with other supplements and medications. The most notable include Alprazolam, Cannabis (THC-Dominant), Clonazepam, Diazepam, and Diphenhydramine.
What works well with Valerian Root?
Valerian Root pairs synergistically with L-Theanine in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Valerian Root with Alprazolam?
NutriStack classifies the Valerian Root and Alprazolam pairing as caution: Valerian root has GABAergic sedative properties that can potentiate alprazolam's CNS depressant effects. The combination may cause excessive sedation, impaired motor... Avoid combining valerian root with alprazolam. If you use valerian for sleep, discontinue it while taking benzodiazepines. Do not drive or operate...
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