Supplement·Interactions·Reviewed June 9, 2026
Vitamin B2 interactions.
Vitamin B2 has 6 documented interactions in the NutriStack database: 6 that work synergistically. The full list, with what each pairing does, is below.
Vitamin B2 at a glance.
A quick, data-grounded summary. The full table is below.
Vitamin B2 has 6 documented interactions in the NutriStack database: 6 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with vitamin b2.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Coenzyme Q10 | Synergy | Riboflavin and coenzyme Q10 both support mitochondrial energy production and are used together for migraine prophylaxis, where their effects on the... |
| Combined Oral Contraceptive | Synergy | Combined oral contraceptives modestly lower riboflavin (B2) status by altering hepatic enzyme turnover and erythrocyte glutathione reductase... details → |
| Iron | Synergy | Riboflavin supports mobilization of stored iron and red blood cell production, so correcting riboflavin status can improve the hematologic response... |
| Methylfolate | Synergy | Riboflavin is the cofactor for the MTHFR enzyme that converts folate to its active form, so good riboflavin status improves folate-mediated lowering... |
| Vitamin B3 | Synergy | B2 (riboflavin) is needed for the synthesis of NAD+ from niacin (B3) via the kynurenine pathway. |
| Vitamin B6 | Synergy | Riboflavin (B2) is needed for the conversion of B6 to its active coenzyme form PLP. |
The full vitamin b2 profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common vitamin b2 questions.
Quick answers drawn from the table above.
What interacts with Vitamin B2?
In the NutriStack database, Vitamin B2 has 6 documented interactions with other supplements and medications. The most notable include Coenzyme Q10, Combined Oral Contraceptive, Iron, Methylfolate, and Vitamin B3.
What works well with Vitamin B2?
Vitamin B2 pairs synergistically with Coenzyme Q10, Combined Oral Contraceptive, Iron, Methylfolate, and Vitamin B3 in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Vitamin B2 with Coenzyme Q10?
NutriStack classifies the Vitamin B2 and Coenzyme Q10 pairing as synergy: Riboflavin and coenzyme Q10 both support mitochondrial energy production and are used together for migraine prophylaxis, where their effects on the electron transport... Reasonable to combine for migraine prevention or mitochondrial support. Common research dosing is riboflavin 400mg daily with CoQ10 around 100mg to...
Check your whole stack
See how vitamin b2 fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.