Supplement·Interactions·Reviewed June 9, 2026
Vitamin B3 interactions.
Vitamin B3 has 12 documented interactions in the NutriStack database: 2 to avoid or watch closely, 6 that need timing or caution, and 4 that work synergistically. The full list, with what each pairing does, is below.
Vitamin B3 at a glance.
A quick, data-grounded summary. The full table is below.
Vitamin B3 has 12 documented interactions in the NutriStack database: 2 to avoid or watch closely, 6 that need timing or caution, and 4 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with vitamin b3.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Allopurinol | Conflict | High-dose Vitamin B3 products that contain niacin or nicotinic acid can raise uric acid and have been associated with drug-induced gout. This can... details → |
| Febuxostat | Conflict | High-dose Vitamin B3 products containing niacin or nicotinic acid can increase serum uric acid and precipitate gout. That effect can work against... details → |
| Atorvastatin | Caution | High-dose niacin (>1g/day) combined with atorvastatin may increase the risk of myopathy and rhabdomyolysis. The AIM-HIGH and HPS2-THRIVE trials also... details → |
| Lovastatin | Caution | High-dose Vitamin B3 as niacin can add muscle, liver, and glucose-related adverse effects to statin therapy. Large statin-era niacin trials found no... details → |
| NMN | Caution | Both are NAD+ precursors through different pathways. Taking both may be redundant and could lead to excessive NAD+ precursor supplementation. |
| Pravastatin | Caution | High-dose Vitamin B3 as niacin can increase adverse effects when added to statin therapy, even though pravastatin has fewer CYP3A4 interaction... details → |
| Rosuvastatin | Caution | High-dose niacin combined with rosuvastatin increases myopathy risk. Clinical trials have shown that adding niacin to statin therapy does not... details → |
| Simvastatin | Caution | The combination of high-dose niacin with simvastatin carries an elevated risk of myopathy and rhabdomyolysis. Simvastatin already has a higher... details → |
| Chromium | Synergy | Combining niacin with chromium has been studied as a way to improve glucose handling. Controlled work in older adults found that niacin-bound or... |
| L-Tryptophan | Synergy | Tryptophan and niacin are linked through a single biosynthetic pathway. Supplemental tryptophan contributes to niacin/NAD+ status, and conversely,... |
| PQQ | Synergy | PQQ and vitamin B3 converge on NAD+ metabolism. This is an on-pathway analog of the better-known PQQ plus NMN/NR combination: PQQ promotes NAD+... |
| Vitamin B2 | Synergy | B2 (riboflavin) is needed for the synthesis of NAD+ from niacin (B3) via the kynurenine pathway. |
The full vitamin b3 profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common vitamin b3 questions.
Quick answers drawn from the table above.
What interacts with Vitamin B3?
In the NutriStack database, Vitamin B3 has 12 documented interactions with other supplements and medications. The most notable include Allopurinol, Febuxostat, Atorvastatin, Lovastatin, and NMN.
What should you not take with Vitamin B3?
Vitamin B3 is flagged against 2 substances in the database, including Allopurinol and Febuxostat. Review these with a clinician before combining, especially alongside prescription medications.
What works well with Vitamin B3?
Vitamin B3 pairs synergistically with Chromium, L-Tryptophan, PQQ, and Vitamin B2 in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Vitamin B3 with Allopurinol?
NutriStack classifies the Vitamin B3 and Allopurinol pairing as conflict: High-dose Vitamin B3 products that contain niacin or nicotinic acid can raise uric acid and have been associated with drug-induced gout. This can work against... Avoid starting high-dose Vitamin B3 while gout is active or serum urate is above target unless your clinician specifically recommends it. If niacin...
Check your whole stack
See how vitamin b3 fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.