Supplement·Interactions·Reviewed June 9, 2026
Vitamin C interactions.
Vitamin C has 70 documented interactions in the NutriStack database: 21 that need timing or caution and 49 that work synergistically. The full list, with what each pairing does, is below.
In short
Vitamin C at a glance.
A quick, data-grounded summary. The full table is below.
Vitamin C has 70 documented interactions in the NutriStack database: 21 that need timing or caution and 49 that work synergistically. The full list, with what each pairing does, is below.
Interactions
Everything that interacts with vitamin c.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Bempedoic Acid | Caution | Bempedoic acid can raise serum uric acid by competing with uric acid for renal tubular secretion via OAT2, and gout has been reported as an adverse... |
| Copper | Caution | Sustained high-dose (gram-level) vitamin C can lower ceruloplasmin oxidase activity and may impair copper status, though effects on copper... details → |
| Dapsone | Caution | Dapsone can cause methemoglobinemia and hemolysis through oxidative metabolites. High-dose vitamin C has reducing and antioxidant activity and has... |
| Esomeprazole | Caution | Esomeprazole lowers the concentration of bioavailable vitamin C in the stomach. In healthy volunteers, four weeks of a PPI reduced plasma vitamin C... details → |
| Famciclovir | Caution | Very high-dose vitamin C can increase urinary oxalate burden, which is undesirable in patients needing renal dose adjustment for famciclovir. |
| GHK-Cu (Copper Peptide) | Caution | Acidic vitamin C products layered with copper peptide cosmetics may increase irritation. |
| Lansoprazole | Caution | Lansoprazole reduces the bioavailability of dietary vitamin C by raising intragastric pH, which destabilizes ascorbate. A four-week trial of a PPI... details → |
| Nicotine | Caution | Nicotine and smoking markedly increase oxidative stress and lower plasma vitamin C levels, so nicotine users often have depleted vitamin C status. details → |
| Tart Cherry Extract | Caution | High-dose antioxidant supplementation around exercise can blunt some of the beneficial training adaptations to endurance and resistance exercise;... |
| Tenofovir Disoproxil | Caution | Tenofovir disoproxil is eliminated renally and can cause nephrotoxicity, including a Fanconi-like proximal tubulopathy, in susceptible patients.... |
| Topiramate | Caution | Topiramate increases kidney-stone risk by causing alkaline urine and hypocitraturia. High-dose vitamin C can increase urinary oxalate and has been... details → |
| Valganciclovir | Caution | Ganciclovir, the active form of valganciclovir, is renally cleared and can be nephrotoxic, with kidney impairment requiring dose reduction. Chronic... |
| Vanadium | Caution | Vitamin C directly alters the chemistry of co-ingested vanadium by reducing vanadate (V) to vanadyl (IV). This is one of the best characterized... details → |
| Vancomycin | Caution | High-dose intravenous or oral vitamin C is being studied and used in some critical-care protocols. Because intravenous vancomycin is cleared renally... |
| Zonisamide | Caution | High-dose vitamin C can increase urinary oxalate in some patients. Zonisamide increases kidney stone risk. |
| Activated Charcoal | Timing Sensitive | Activated charcoal adsorbs ascorbic acid in the gut, lowering the fraction of an oral vitamin C dose that is absorbed. details → |
| Amphetamine/Dextroamphetamine | Timing Sensitive | High-dose Vitamin C products are usually ascorbic acid, and acidifying conditions can lower amphetamine blood levels by increasing renal clearance... details → |
| Lisdexamfetamine | Timing Sensitive | Lisdexamfetamine is converted to dextroamphetamine after absorption, and the active amphetamine exposure can be affected by urinary pH. High-dose... details → |
| Manganese | Timing Sensitive | Vitamin C is documented to increase absorption of non-heme divalent metals via the DMT1 pathway that manganese also uses. Co-ingesting vitamin C... |
| Selenium | Timing Sensitive | High-dose vitamin C may reduce selenite to elemental selenium, which is not absorbable. Does not affect selenomethionine forms. details → |
| Vitamin B12 | Timing Sensitive | High-dose vitamin C (>500mg) may destroy vitamin B12 when taken simultaneously. The acidic environment created by high-dose ascorbic acid can... details → |
| Acyclovir | Synergy | Vitamin C has in vitro antiviral activity against HSV and supports immune function, and a topical ascorbate solution showed modest benefit in... |
| Allopurinol | Synergy | Allopurinol promotes oxidative stress that can deplete plasma ascorbate levels. Vitamin C supplementation may help offset this depletion and provide... details → |
| Alpha-Lipoic Acid | Synergy | ALA regenerates vitamin C from its oxidized form (dehydroascorbate) back to ascorbate. |
| Andrographis | Synergy | Both are used for respiratory symptom support with different mechanisms. |
| Anthocyanins (Bilberry Extract) | Synergy | Vitamin C and bilberry anthocyanins are complementary antioxidants. Ascorbate can help regenerate and stabilize flavonoid antioxidants, and the... |
| Bee Pollen | Synergy | Bee pollen contains flavonoids and polyphenols whose antioxidant activity can be complemented by vitamin C, supporting a mild synergistic... |
| Beta-Glucan | Synergy | Both are used for immune resilience and may be complementary. |
| Calcium | Synergy | Vitamin C mildly enhances calcium absorption by maintaining calcium in the soluble, ionized form in the gut. |
| Carnosine | Synergy | Carnosine and vitamin C are both antioxidants that operate in the aqueous cellular phase and can broaden free-radical and carbonyl-stress coverage... |
| Chondroitin | Synergy | Vitamin C supports synthesis and stabilization of the cartilage matrix that chondroitin sulfate is part of, so the two complement each other for... |
| Chromium | Synergy | Vitamin C enhances chromium absorption by reducing Cr3+ in the gut, making it more bioavailable. details → |
| Collagen Peptides | Synergy | Vitamin C is essential for collagen synthesis. It's a required cofactor for prolyl and lysyl hydroxylase enzymes that stabilize the collagen triple... details → |
| Combined Oral Contraceptive | Synergy | Combined oral contraceptives lower plasma and platelet vitamin C levels and increase oxidative stress, partly because estrogen induces hepatic... details → |
| D-Mannose | Synergy | D-Mannose and Vitamin C are frequently combined in UTI prevention products, often alongside cranberry. In trial arms that paired D-Mannose with... |
| Echinacea | Synergy | Echinacea and vitamin C are commonly combined for upper respiratory immune support, with modest evidence for reducing cold duration or severity when... |
| Elderberry | Synergy | Combined antioxidant and immune support during early upper respiratory infection, with complementary effects on innate immune function. |
| Ellagic Acid | Synergy | Vitamin C is a water-soluble antioxidant that can regenerate other oxidized antioxidants and complements the free-radical scavenging and... |
| Ergothioneine | Synergy | Vitamin C is an aqueous-phase antioxidant and can help regenerate other antioxidants, while ergothioneine provides stable intracellular and... |
| Febuxostat | Synergy | Vitamin C has a modest urate-lowering effect in randomized-trial meta-analyses, while febuxostat is a much stronger urate-lowering medicine. The... details → |
| Gotu Kola | Synergy | Vitamin C is an essential cofactor for prolyl and lysyl hydroxylase in collagen synthesis, while gotu kola triterpenoids stimulate fibroblast... |
| Grape Seed Extract | Synergy | Vitamin C helps regenerate oxidized proanthocyanidin antioxidants, and the two together support endothelial and vascular antioxidant capacity. |
| Hesperidin | Synergy | Hesperidin and other citrus bioflavonoids are traditionally co-administered with vitamin C and may support capillary integrity and antioxidant... |
| Hyaluronic Acid | Synergy | Vitamin C is a required cofactor for collagen synthesis, supporting the extracellular matrix environment where hyaluronic acid contributes hydration. |
| Iron | Synergy | Vitamin C dramatically increases non-heme iron absorption by reducing ferric iron (Fe3+) to ferrous iron (Fe2+) and forming a soluble chelate. details → |
| Iron Bisglycinate | Synergy | Vitamin C dramatically increases non-heme iron bisglycinate absorption by reducing ferric iron bisglycinate (Fe3+) to ferrous iron bisglycinate... details → |
| L-Glutathione | Synergy | Vitamin C and glutathione recycle each other within the cellular antioxidant network, and vitamin C helps spare and maintain reduced glutathione... |
| L-Tyrosine | Synergy | Vitamin C is a cofactor for dopamine beta-hydroxylase, which converts dopamine (from tyrosine) to norepinephrine. |
| Lactoferrin | Synergy | Vitamin C may support immune function and iron absorption while lactoferrin supports mucosal defense. |
| Methylfolate | Synergy | Vitamin C protects folate from oxidative degradation and helps maintain it in its reduced, active form. |
| MitoQ (Mitoquinone) | Synergy | Vitamin C is a water-soluble antioxidant that can recycle the oxidized ubiquinone moiety back to its reduced ubiquinol form, complementing MitoQ's... |
| Moringa | Synergy | Vitamin C enhances absorption of the non-heme iron in moringa and supports its antioxidant activity, improving the nutritional value of the... |
| MSM | Synergy | MSM provides sulfur and antioxidant support that complements vitamin C's role in collagen synthesis, and the pair is frequently combined for... |
| NAC | Synergy | NAC replenishes intracellular glutathione, while vitamin C provides extracellular antioxidant support. Complementary antioxidant systems. details → |
| Oligonol (Lychee Polyphenol) | Synergy | Oligonol is a polyphenol antioxidant and vitamin C is a water-soluble antioxidant; together they contribute complementary free-radical scavenging,... |
| Omeprazole | Synergy | PPIs like omeprazole reduce gastric vitamin C levels by increasing gastric pH, which oxidizes ascorbic acid to its less bioavailable form. Vitamin C... details → |
| Pantoprazole | Synergy | Pantoprazole, like other PPIs, may reduce gastric vitamin C levels by altering the gastric pH environment. Vitamin C supplementation can help... details → |
| Pine Bark Extract | Synergy | Vitamin C regenerates the oxidized flavonoid components of pine bark extract, helping sustain their antioxidant and endothelial-protective activity. |
| Polyethylene Glycol | Synergy | Polyethylene glycol bowel-preparation products are sometimes formulated with gram-dose ascorbic acid to improve cleansing with a lower PEG volume.... details → |
| PQQ | Synergy | Vitamin C and PQQ can work together as a coupled redox antioxidant system. Ascorbic acid donates electrons to convert PQQ into PQQH2, the form... |
| Quercetin | Synergy | Quercetin and vitamin C have synergistic antioxidant effects. Vitamin C helps regenerate oxidized quercetin. |
| Rabeprazole | Synergy | Vitamin C can improve non-heme iron absorption and may partly offset reduced iron solubility during acid suppression. |
| Royal Jelly | Synergy | Royal jelly and vitamin C provide complementary antioxidant support without a known adverse interaction, and are commonly combined in supplements. |
| Rutin | Synergy | Rutin and vitamin C are classically combined for capillary support. Vitamin C contributes to collagen synthesis and vascular integrity while rutin... |
| Spirulina | Synergy | Vitamin C taken with spirulina improves absorption of spirulina's non-heme iron, supporting its use for iron status. |
| Sulforaphane | Synergy | When sulforaphane is taken in precursor (glucoraphanin) form, vitamin C can improve its conversion to the active molecule by supporting the... |
| Valacyclovir | Synergy | Vitamin C has in vitro antiviral effects against HSV and supports immune function; combined with valacyclovir for recurrent HSV it offers a... |
| Vitamin B5 | Synergy | Both support adrenal function and cortisol regulation. B5 (pantothenic acid) is critical for CoA synthesis needed in adrenal steroid hormone... details → |
| Vitamin B9 | Synergy | Vitamin C protects folate from oxidative degradation and helps maintain it in its reduced, active form. |
| Vitamin E | Synergy | Vitamin C regenerates vitamin E from its oxidized tocopheroxyl radical form, extending its antioxidant capacity. |
Go deeper
The full vitamin c profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
FAQ
Common vitamin c questions.
Quick answers drawn from the table above.
What interacts with Vitamin C?
In the NutriStack database, Vitamin C has 70 documented interactions with other supplements and medications. The most notable include Bempedoic Acid, Copper, Dapsone, Esomeprazole, and Famciclovir.
What works well with Vitamin C?
Vitamin C pairs synergistically with Acyclovir, Allopurinol, Alpha-Lipoic Acid, Andrographis, and Anthocyanins (Bilberry Extract) in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Vitamin C with Bempedoic Acid?
NutriStack classifies the Vitamin C and Bempedoic Acid pairing as caution: Bempedoic acid can raise serum uric acid by competing with uric acid for renal tubular secretion via OAT2, and gout has been reported as an adverse effect. High-dose... Normal dietary or low-dose supplemental vitamin C is fine with bempedoic acid. If you take gram-level vitamin C and have gout, hyperuricemia, or a...
Check your whole stack
See how vitamin c fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.