Supplement·Interactions·Reviewed June 9, 2026
Vitamin E interactions.
Vitamin E has 31 documented interactions in the NutriStack database: 17 that need timing or caution and 14 that work synergistically. The full list, with what each pairing does, is below.
Vitamin E at a glance.
A quick, data-grounded summary. The full table is below.
Vitamin E has 31 documented interactions in the NutriStack database: 17 that need timing or caution and 14 that work synergistically. The full list, with what each pairing does, is below.
Everything that interacts with vitamin e.
Every supplement and medication in the NutriStack database with a documented interaction with this substance, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Aspirin Low-Dose | Caution | High-dose vitamin E may increase bleeding tendency and could add to low-dose aspirin's antiplatelet effect. Vitamin E supplementation has been shown... details → |
| Ezetimibe | Caution | As a fat-soluble vitamin absorbed through the same micellar lipid pathway affected by ezetimibe, vitamin E (tocopherol) absorption may be modestly... |
| Fish Oil | Caution | High-dose fish oil increases vitamin E requirements because PUFAs are susceptible to peroxidation. May deplete vitamin E stores. details → |
| Fish Oil Triple Strength | Caution | High-dose fish oil triple strength increases vitamin E requirements because PUFAs are susceptible to peroxidation. May deplete vitamin E stores. details → |
| Gemfibrozil | Caution | High-dose vitamin E has antiplatelet/anticoagulant properties and can potentiate bleeding risk. Gemfibrozil itself can potentiate oral... |
| Ginkgo Biloba | Caution | Both have antiplatelet activity at higher doses; combined use raises bleeding risk in surgical and anticoagulated patients. |
| Icosapent Ethyl | Caution | Vitamin E may increase bleeding tendency and can be a concern with Icosapent Ethyl when high-dose vitamin E is combined with omega-3 therapy or... |
| Krill Oil | Caution | High-dose krill oil increases vitamin E requirements because PUFAs are susceptible to peroxidation. May deplete vitamin E stores. details → |
| Sea Buckthorn Oil | Caution | Sea buckthorn oil contains tocopherols, and high-dose vitamin E may add bleeding-risk concerns. |
| Thymosin Beta-4 | Caution | High-dose vitamin E may increase bruising risk around injections or procedures. |
| Tocotrienols | Caution | Combining tocotrienols with high-dose vitamin E can increase total vitamin E exposure and bleeding risk. |
| Vitamin K1 | Caution | High-dose vitamin E (>400 IU) can antagonize vitamin K-dependent clotting factor activation, increasing bleeding risk. details → |
| Vitamin K2 | Caution | High-dose vitamin E may reduce K2-dependent protein carboxylation, potentially affecting both bone and cardiovascular K2 benefits. |
| Vitamin K2 MK-4 | Caution | High-dose vitamin E may reduce K2-dependent protein carboxylation, potentially affecting both bone and cardiovascular K2 benefits. |
| Warfarin | Caution | High-dose vitamin E may potentiate warfarin's anticoagulant effect and increase bleeding risk. Vitamin E at high supplemental doses can interfere... details → |
| Cholestyramine | Timing Sensitive | Cholestyramine can reduce absorption of fat-soluble vitamin E during long-term use. |
| Plant Sterols (Phytosterols) | Timing Sensitive | Plant sterols can reduce absorption of some fat-soluble compounds and carotenoids. |
| Astaxanthin | Synergy | Both are lipophilic antioxidants but work at different positions in cell membranes. Astaxanthin is 6000x more potent than vitamin C as a singlet... details → |
| Beta-Carotene | Synergy | Beta-carotene and vitamin E are complementary antioxidants that protect different cellular compartments, and vitamin E can help protect... |
| CLA | Synergy | CLA can increase lipid peroxidation and oxidative-stress markers, which raises the body's vitamin E (antioxidant) requirement. Pairing CLA with... |
| Coenzyme Q10 | Synergy | CoQ10 (ubiquinol form) regenerates vitamin E from its oxidized form in cell membranes, similar to how vitamin C regenerates vitamin E. |
| Coenzyme Q10 Ubiquinol | Synergy | CoQ10 (ubiquinol form) regenerates vitamin E from its oxidized form in cell membranes, similar to how vitamin C regenerates vitamin E. |
| Combined Oral Contraceptive | Synergy | Combined oral contraceptives reduce serum levels of lipid-soluble antioxidants including alpha-tocopherol and coenzyme Q10. In a controlled study of... details → |
| Evening Primrose Oil | Synergy | Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin E. |
| Flaxseed Oil | Synergy | Flaxseed Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin E. |
| Lycopene | Synergy | Lycopene and vitamin E are lipid-soluble antioxidants that work together in cell membranes and lipoproteins, with vitamin E helping spare and... |
| MCT Oil | Synergy | MCT Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Vitamin E. |
| Selenium | Synergy | Selenium and vitamin E work synergistically as antioxidants. Selenium is part of glutathione peroxidase, while E breaks lipid peroxidation chains. details → |
| Vitamin A | Synergy | Vitamin E protects vitamin A from oxidation in the gut, increasing its absorption and stability. |
| Vitamin C | Synergy | Vitamin C regenerates vitamin E from its oxidized tocopheroxyl radical form, extending its antioxidant capacity. |
| Vitamin C Liposomal | Synergy | Vitamin C Liposomal regenerates vitamin E from its oxidized tocopheroxyl radical form, extending its antioxidant capacity. |
The full vitamin e profile.
Benefits, dosing by goal, forms, and the cited evidence for this supplement.
Common vitamin e questions.
Quick answers drawn from the table above.
What interacts with Vitamin E?
In the NutriStack database, Vitamin E has 31 documented interactions with other supplements and medications. The most notable include Aspirin Low-Dose, Ezetimibe, Fish Oil, Fish Oil Triple Strength, and Gemfibrozil.
What works well with Vitamin E?
Vitamin E pairs synergistically with Astaxanthin, Beta-Carotene, CLA, Coenzyme Q10, and Coenzyme Q10 Ubiquinol in the NutriStack database. Synergy still depends on dose and timing; open any pair for the detail.
Can you take Vitamin E with Aspirin Low-Dose?
NutriStack classifies the Vitamin E and Aspirin Low-Dose pairing as caution: High-dose vitamin E may increase bleeding tendency and could add to low-dose aspirin's antiplatelet effect. Vitamin E supplementation has been shown to affect vitamin K... Avoid high-dose vitamin E while taking low-dose aspirin unless your clinician recommends it. Keep supplemental vitamin E modest and report unusual...
Check your whole stack
See how vitamin e fits your routine.
NutriStack screens your full stack for interactions and timing conflicts, and updates the moment you change it.