Protocol·Longevity·Intermediate·Reviewed June 9, 2026
Brain Longevity & Neuroprotection Protocol.
A long-horizon stack aimed at supporting neuronal membrane integrity, cerebral blood flow, and cognitive resilience as you age. These supplements are intended as supportive, adjunctive measures alongside sleep, exercise, and clinical care, and are not a treatment or cure for any cognitive or neurological condition.
The brain longevity & neuroprotection protocol in brief.
A quick summary. The full stack, with dose and timing for each supplement, is below.
The Brain Longevity & Neuroprotection Protocol is an intermediate stack of 7 supplements aimed at longevity: Fish Oil, Citicoline, Magnesium L-Threonate, Turmeric/Curcumin, Phosphatidylserine, Methylcobalamin, and Lion's Mane. 3 are core and the rest are optional add-ons, at roughly $50-85/mo. Each supplement below lists its dose, timing, role, and the evidence behind it.
What is in the brain longevity & neuroprotection protocol.
Dose, timing, role, and evidence tier for each supplement. Core items carry the protocol; optional ones are situational. Open any name for the full profile.
| Supplement | Dose | Timing | Role | Evidence |
|---|---|---|---|---|
| Fish Oil | 1000-2000 mg combined EPA plus DHA | With a fat-containing meal, morning or evening | Core | Moderate |
| Citicoline | 250-500 mg | Morning with food | Core | Moderate |
| Magnesium L-Threonate | 1000-2000 mg (providing roughly 70-145 mg elemental magnesium) | Evening, away from other minerals | Core | Emerging |
| Turmeric/Curcumin | 500-1000 mg of a bioavailability-enhanced curcumin extract | With a fat-containing meal | Optional | Emerging |
| Phosphatidylserine | 100 mg up to three times daily (300 mg total) | With meals, spread across the day | Optional | Moderate |
| Methylcobalamin | 500-1000 mcg | Morning with food | Optional | Moderate |
| Lion's Mane | 500-1000 mg extract | Morning with food | Optional | Emerging |
DHA is a major structural fatty acid of neuronal membranes and synapses, and higher omega-3 status is associated in observational and some interventional work with better-preserved brain volume and cognitive function. Benefits for long-term neuroprotection remain an area of active study rather than settled fact.
Citicoline supplies choline and cytidine used to synthesize phosphatidylcholine for neuronal membranes and to support acetylcholine production. Human trials suggest modest support for attention and memory in some older adults, though long-term neuroprotective effects are still emerging.
Magnesium L-Threonate is formulated to raise brain magnesium, which is involved in NMDA receptor regulation and synaptic plasticity. Cognitive benefits in humans are early and emerging, so treat it as a supportive option rather than an established intervention, and count its elemental magnesium toward your daily total.
Curcumin has antioxidant and anti-inflammatory activity that may help buffer the chronic low-grade neuroinflammation linked to cognitive aging, with one small trial reporting memory and attention benefits. Evidence is preliminary and limited by curcumin's poor absorption, so use only standardized, well-absorbed forms.
Phosphatidylserine is a membrane phospholipid concentrated in neurons, and supplementation has shown modest support for memory and processing in some studies of age-related cognitive decline. The effect size is small and the long-term picture is still developing.
Methylcobalamin is an active form of vitamin B12 needed for myelin maintenance and for keeping homocysteine in a healthy range, and correcting B12 insufficiency supports neurological function. It is most clearly useful for those with low or borderline B12 status rather than as a universal cognitive enhancer.
Lion's Mane contains compounds reported in preclinical work to stimulate nerve growth factor expression, with a few small human trials hinting at cognitive support. Human evidence remains early and underpowered, so consider it an experimental adjunct.
How the pieces combine.
The mechanistic rationale for stacking these together rather than taking them in isolation.
- Take Fish Oil and Turmeric/Curcumin together with the same fat-containing meal: both are fat-soluble and absorb better with dietary fat, and curcumin's anti-inflammatory action complements omega-3 membrane support.
- Citicoline and Phosphatidylserine both feed into neuronal membrane phospholipid pathways and pair well; spacing Phosphatidylserine doses across meals keeps levels steady through the day.
- Separate Magnesium L-Threonate to the evening, away from Methylcobalamin and other minerals taken in the morning, to limit mineral competition for absorption and to align with its calming, sleep-friendly timing.
- Methylcobalamin supports healthy homocysteine alongside the broader stack, but if you have a known B12 deficiency or take metformin, acid reducers, or other interacting medication, have your status and dosing reviewed by a clinician rather than self-correcting.
- Fish Oil, Turmeric/Curcumin, and Lion's Mane can each affect bleeding tendency or interact with anticoagulants and antiplatelet drugs; if you take blood thinners, are pregnant or breastfeeding, or are managing a diagnosed neurological condition, treat this stack as supportive only and clear it with your physician first.
Cost and commitment.
A rough monthly cost and how involved the protocol is to run.
The evidence behind it.
Overview citations for this protocol. Each supplement's own profile carries its full source list.
- Gómez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci. 2008;9(7):568-78. PubMed
- Solfrizzi V et al. Relationships of Dietary Patterns, Foods, and Micro- and Macronutrients with Alzheimer's Disease and Late-Life Cognitive Disorders: A Systematic Review. J Alzheimers Dis. 2017;59(3):815-849. PubMed
- Dominguez LJ et al. Nutritional prevention of cognitive decline and dementia. Acta Biomed. 2018;89(2):276-290. PubMed
Common questions.
Quick answers drawn from the stack above.
What is in the Brain Longevity & Neuroprotection Protocol?
The Brain Longevity & Neuroprotection Protocol combines 7 supplements for longevity: Fish Oil, Citicoline, Magnesium L-Threonate, Turmeric/Curcumin, Phosphatidylserine, Methylcobalamin, and Lion's Mane. 3 are core; the rest are optional.
How much does the Brain Longevity & Neuroprotection Protocol cost?
NutriStack estimates the Brain Longevity & Neuroprotection Protocol at about $50-85/mo, depending on the forms and brands you choose and whether you run the optional add-ons.
Is the Brain Longevity & Neuroprotection Protocol backed by evidence?
Each supplement in the protocol carries its own evidence tier (0 rated strong here) and links to PubMed-cited sources. NutriStack does not rank or score brands and takes no manufacturer payments; this is an informational reference, not medical advice.
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