Protocol·Inflammation·Intermediate·Reviewed June 9, 2026
Chronic Inflammation Protocol.
Reduce systemic inflammatory markers (hsCRP, IL-6) and support resolution pathways for chronic low-grade inflammation.
The chronic inflammation protocol in brief.
A quick summary. The full stack, with dose and timing for each supplement, is below.
The Chronic Inflammation Protocol is an intermediate stack of 5 supplements aimed at inflammation: Curcumin Phytosome, Fish Oil Triple Strength, Vitamin D3, Boswellia, and Quercetin. 3 are core and the rest are optional add-ons, at roughly $35-60/mo. Each supplement below lists its dose, timing, role, and the evidence behind it.
What is in the chronic inflammation protocol.
Dose, timing, role, and evidence tier for each supplement. Core items carry the protocol; optional ones are situational. Open any name for the full profile.
| Supplement | Dose | Timing | Role | Evidence |
|---|---|---|---|---|
| Curcumin Phytosome | 500 to 1000 mg | Twice daily with food | Core | Strong |
| Fish Oil Triple Strength | 2 to 3 g EPA+DHA | With meals | Core | Strong |
| Vitamin D3 | 3000 to 5000 IU | With morning fat | Core | Moderate |
| Boswellia | 100 to 300 mg AKBA extract | Twice daily | Optional | Moderate |
| Quercetin | 500 mg | Twice daily | Optional | Moderate |
Curcumin phytosome (Meriva) has 29-fold better bioavailability than standard curcumin and lowers hsCRP across multiple inflammatory conditions.
EPA and DHA reduce inflammatory eicosanoids and resolve inflammation via specialized pro-resolving mediators (SPMs).
Vitamin D modulates Th1/Th17 balance and reduces inflammatory cytokines; deficiency exacerbates chronic inflammation.
5-LOX inhibitor with strong joint and gut inflammation evidence; AKBA-standardized extracts (ApresFlex) outperform standard boswellia.
Mast cell stabilizer and NLRP3 inflammasome modulator; reduces hsCRP and supports inflammatory resolution.
How the pieces combine.
The mechanistic rationale for stacking these together rather than taking them in isolation.
- Curcumin + Fish Oil have additive anti-inflammatory effects via NF-kB and eicosanoid pathways
- Quercetin + Curcumin both modulate NF-kB with complementary upstream targets
- Vitamin D primes immune regulatory function that the rest of the stack acts on
Cost and commitment.
A rough monthly cost and how involved the protocol is to run.
The evidence behind it.
Overview citations for this protocol. Each supplement's own profile carries its full source list.
- Calder PC et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr. 2009;101 Suppl 1:S1-45. PubMed
Common questions.
Quick answers drawn from the stack above.
What is in the Chronic Inflammation Protocol?
The Chronic Inflammation Protocol combines 5 supplements for inflammation: Curcumin Phytosome, Fish Oil Triple Strength, Vitamin D3, Boswellia, and Quercetin. 3 are core; the rest are optional.
How much does the Chronic Inflammation Protocol cost?
NutriStack estimates the Chronic Inflammation Protocol at about $35-60/mo, depending on the forms and brands you choose and whether you run the optional add-ons.
Is the Chronic Inflammation Protocol backed by evidence?
Each supplement in the protocol carries its own evidence tier (2 rated strong here) and links to PubMed-cited sources. NutriStack does not rank or score brands and takes no manufacturer payments; this is an informational reference, not medical advice.
Build it in the app
Run the chronic inflammation protocol in NutriStack.
Add the stack to NutriStack to track timing, screen it for interactions, and see a Stack Score that updates as you tune it.