Protocol·Focus·Intermediate·Reviewed June 9, 2026
Focus & Cognition Protocol.
Enhance acetylcholine signaling, neuroplasticity, and prefrontal cortex function for sustained mental clarity.
The focus & cognition protocol in brief.
A quick summary. The full stack, with dose and timing for each supplement, is below.
The Focus & Cognition Protocol is an intermediate stack of 5 supplements aimed at focus: Lion's Mane, Citicoline, L-Tyrosine, Creatine, and Alpha-GPC. 3 are core and the rest are optional add-ons, at roughly $40-65/mo. Each supplement below lists its dose, timing, role, and the evidence behind it.
What is in the focus & cognition protocol.
Dose, timing, role, and evidence tier for each supplement. Core items carry the protocol; optional ones are situational. Open any name for the full profile.
| Supplement | Dose | Timing | Role | Evidence |
|---|---|---|---|---|
| Lion's Mane | 1000 mg | Morning | Core | Moderate |
| Citicoline | 300 mg | Morning | Core | Moderate |
| L-Tyrosine | 500 mg | Morning, empty stomach | Optional | Moderate |
| Creatine | 5 g | Morning | Optional | Moderate |
| Alpha-GPC | 300 mg | Morning | Core | Moderate |
Stimulates nerve growth factor (NGF) synthesis to support neuroplasticity and long-term cognitive health
Provides choline and cytidine for acetylcholine and phospholipid synthesis; improves focus and attention
Precursor to dopamine and norepinephrine; particularly effective under stress or sleep deprivation
Brain tissue demands high ATP; creatine supplementation supports cognitive processing and working memory
Most bioavailable choline source; rapidly crosses blood-brain barrier to boost acetylcholine for memory and attention
How the pieces combine.
The mechanistic rationale for stacking these together rather than taking them in isolation.
- Citicoline + Alpha-GPC provide dual-pathway choline loading for robust acetylcholine synthesis
- Lion's Mane promotes neuroplasticity while cholinergics enhance real-time neurotransmission
- L-Tyrosine supports dopamine under stress, complementing cholinergic focus pathways
Cost and commitment.
A rough monthly cost and how involved the protocol is to run.
The evidence behind it.
Overview citations for this protocol. Each supplement's own profile carries its full source list.
- Suliman NA et al. Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic. Evid Based Complement Alternat Med. 2016;2016:4391375. PubMed
Common questions.
Quick answers drawn from the stack above.
What is in the Focus & Cognition Protocol?
The Focus & Cognition Protocol combines 5 supplements for focus: Lion's Mane, Citicoline, L-Tyrosine, Creatine, and Alpha-GPC. 3 are core; the rest are optional.
How much does the Focus & Cognition Protocol cost?
NutriStack estimates the Focus & Cognition Protocol at about $40-65/mo, depending on the forms and brands you choose and whether you run the optional add-ons.
Is the Focus & Cognition Protocol backed by evidence?
Each supplement in the protocol carries its own evidence tier (0 rated strong here) and links to PubMed-cited sources. NutriStack does not rank or score brands and takes no manufacturer payments; this is an informational reference, not medical advice.
Build it in the app
Run the focus & cognition protocol in NutriStack.
Add the stack to NutriStack to track timing, screen it for interactions, and see a Stack Score that updates as you tune it.