Protocol·Liver Health·Beginner·Reviewed June 9, 2026
Liver Support Protocol.
Support hepatic detoxification phases I and II, reduce ALT/AST in fatty liver, and provide antioxidant protection to hepatocytes.
The liver support protocol in brief.
A quick summary. The full stack, with dose and timing for each supplement, is below.
The Liver Support Protocol is a beginner stack of 5 supplements aimed at liver health: Milk Thistle, NAC, Vitamin E, Sulforaphane, and Schisandra. 2 are core and the rest are optional add-ons, at roughly $25-50/mo. Each supplement below lists its dose, timing, role, and the evidence behind it.
What is in the liver support protocol.
Dose, timing, role, and evidence tier for each supplement. Core items carry the protocol; optional ones are situational. Open any name for the full profile.
| Supplement | Dose | Timing | Role | Evidence |
|---|---|---|---|---|
| Milk Thistle | 140 to 280 mg silymarin | Twice daily with food | Core | Moderate |
| NAC | 600 mg | Twice daily | Core | Moderate |
| Vitamin E | 400 to 800 IU mixed tocopherols | With evening meal | Optional | Strong |
| Sulforaphane | 20 to 40 mg | Morning | Optional | Emerging |
| Schisandra | 500 to 1500 mg | Twice daily | Optional | Emerging |
Silymarin (preferably silybin phytosome) modestly lowers ALT and AST in NAFLD and chronic liver disease through antioxidant and membrane stabilization mechanisms.
Glutathione precursor; supports phase II detoxification and is the antidote for acetaminophen hepatotoxicity.
Vitamin E 800 IU/day improved NASH histology in PIVENS RCT; long-term safety at high doses requires monitoring.
Potent Nrf2 activator inducing phase II detox enzymes (GST, NQO1, HO-1); supports hepatocyte oxidative resilience.
Schisandra lignans support hepatocyte regeneration and reduce ALT in chronic hepatitis; inhibits CYP3A4 with drug interaction implications.
How the pieces combine.
The mechanistic rationale for stacking these together rather than taking them in isolation.
- Milk Thistle + NAC both support glutathione status through complementary mechanisms
- Sulforaphane induces phase II enzymes that consume the substrates NAC provides
- Vitamin E protects hepatocyte membranes that silymarin stabilizes
Cost and commitment.
A rough monthly cost and how involved the protocol is to run.
The evidence behind it.
Overview citations for this protocol. Each supplement's own profile carries its full source list.
- Eslamparast T et al. Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease. World J Hepatol. 2015;7(2):204-12. PubMed
Common questions.
Quick answers drawn from the stack above.
What is in the Liver Support Protocol?
The Liver Support Protocol combines 5 supplements for liver health: Milk Thistle, NAC, Vitamin E, Sulforaphane, and Schisandra. 2 are core; the rest are optional.
How much does the Liver Support Protocol cost?
NutriStack estimates the Liver Support Protocol at about $25-50/mo, depending on the forms and brands you choose and whether you run the optional add-ons.
Is the Liver Support Protocol backed by evidence?
Each supplement in the protocol carries its own evidence tier (1 rated strong here) and links to PubMed-cited sources. NutriStack does not rank or score brands and takes no manufacturer payments; this is an informational reference, not medical advice.
Build it in the app
Run the liver support protocol in NutriStack.
Add the stack to NutriStack to track timing, screen it for interactions, and see a Stack Score that updates as you tune it.