Protocol·Longevity·Advanced·Reviewed June 9, 2026
Longevity Protocol.
Support healthy-aging routines by focusing on nutrient status, oxidative-stress markers, and metabolic research areas without implying clinical-outcome guarantees.
The longevity protocol in brief.
A quick summary. The full stack, with dose and timing for each supplement, is below.
The Longevity Protocol is an advanced stack of 5 supplements aimed at longevity: NMN, Resveratrol, Vitamin D3, Fish Oil, and NAC. 4 are core and the rest are optional add-ons, at roughly $60-100/mo. Each supplement below lists its dose, timing, role, and the evidence behind it.
What is in the longevity protocol.
Dose, timing, role, and evidence tier for each supplement. Core items carry the protocol; optional ones are situational. Open any name for the full profile.
| Supplement | Dose | Timing | Role | Evidence |
|---|---|---|---|---|
| NMN | 500 mg | Morning | Core | Emerging |
| Resveratrol | 500 mg | Morning with fat | Core | Moderate |
| Vitamin D3 | 1,000-2,000 IU | Morning with food | Core | Strong |
| Fish Oil | 2 g | With meals | Core | Strong |
| NAC | 600 mg | Morning | Optional | Moderate |
NAD+ precursor studied in early human trials for NAD+ and selected metabolic or muscle-function markers; clinical outcome benefits are not established.
Polyphenol studied for metabolic and oxidative-stress markers; pathway findings should not be treated as proven cardiovascular outcome benefits.
Supports vitamin D status when intake or labs are low; dose should be adjusted to 25-OH vitamin D and calcium context.
EPA and DHA are studied for triglyceride, inflammatory, and cardiometabolic markers; aging-outcome claims remain indirect.
Precursor to glutathione studied for oxidative-stress biology; broad detoxification or cellular-protection outcomes should be treated cautiously.
How the pieces combine.
The mechanistic rationale for stacking these together rather than taking them in isolation.
- NMN + Resveratrol are often paired in NAD+-pathway research, but human outcome benefits remain uncertain
- NAC supports glutathione biology while NMN is studied for NAD+ markers; neither should be framed as proven clinical outcome support
- Fish Oil may support cardiometabolic markers alongside other healthy-aging routines
Cost and commitment.
A rough monthly cost and how involved the protocol is to run.
The evidence behind it.
Overview citations for this protocol. Each supplement's own profile carries its full source list.
Common questions.
Quick answers drawn from the stack above.
What is in the Longevity Protocol?
The Longevity Protocol combines 5 supplements for longevity: NMN, Resveratrol, Vitamin D3, Fish Oil, and NAC. 4 are core; the rest are optional.
How much does the Longevity Protocol cost?
NutriStack estimates the Longevity Protocol at about $60-100/mo, depending on the forms and brands you choose and whether you run the optional add-ons.
Is the Longevity Protocol backed by evidence?
Each supplement in the protocol carries its own evidence tier (2 rated strong here) and links to PubMed-cited sources. NutriStack does not rank or score brands and takes no manufacturer payments; this is an informational reference, not medical advice.
Build it in the app
Run the longevity protocol in NutriStack.
Add the stack to NutriStack to track timing, screen it for interactions, and see a Stack Score that updates as you tune it.