NutriStack
Apixaban and Turmeric/Curcumin, a caution.
Curcumin has antiplatelet properties that may increase bleeding risk when combined with apixaban. While no direct pharmacokinetic interaction has been established, the additive effect on hemostasis through different mechanisms warrants caution.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Apixaban and Turmeric/Curcumin
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Curcumin has antiplatelet properties that may increase bleeding risk when combined with apixaban. While no direct pharmacokinetic interaction has been established, the additive effect on hemostasis through different mechanisms warrants caution.
Mechanism. Curcumin inhibits platelet aggregation by suppressing thromboxane A2 synthesis and blocking calcium signaling. This antiplatelet effect adds to apixaban's anticoagulant activity (Factor Xa inhibition), increasing overall bleeding risk through complementary hemostatic pathways.
Recommendation. Use low-dose curcumin cautiously with apixaban. Avoid high-dose curcumin supplements. Watch for signs of unusual bleeding or bruising and report them to your healthcare provider.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Apixaban and Turmeric/Curcumin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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