NutriStack
NutriStack Research/2,517 pairs·584 substances·source limits shown
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2,517 catalogued supplement and prescription pair records across 584 substances. Attached sources may support an ingredient or mechanism without testing the exact pair. No login, no paywall, no proprietary score.
32 shown · Browse interaction guides → · Check any of 2,517 pairs →
Inspect an exact pair record
Choose two substances to inspect the stored mechanism, timing, recommendation, attached source links, and evidence limits.
What is in the index
The shape of the public database.
Counts
- Pairs
- 2,517
- Substances
- 584
- Interaction rows
- 2,544
- Prescription pairs
- 1,445
- Supplement-only pairs
- 1,072
Verdict distribution
Distribution by stored primary label. Many records are labeled potential synergies; the attached evidence determines whether an exact combination has been studied.
Featured pairs
12- Iron × Vitamin CSynergyVitamin C dramatically increases non-heme iron absorption by reducing ferric iron (Fe3+) to ferrous iron (Fe2+) and forming a…
- Calcium × IronConflictCalcium significantly inhibits both heme and non-heme iron absorption when taken simultaneously.
- Vitamin D3 × Vitamin K2SynergyVitamin D supports calcium absorption, while vitamin K is required for normal vitamin-K-dependent proteins involved in bone and…
- 5-HTP × L-TryptophanContraindicatedBoth 5-HTP and L-Tryptophan increase serotonin synthesis. Combining them creates additive serotonin excess
- Atorvastatin × Coenzyme Q10 UbiquinolSynergyAtorvastatin inhibits HMG-CoA reductase, which also reduces endogenous CoQ10 synthesis.
- Calcium × LevothyroxineTiming SensitiveCalcium supplements significantly reduce levothyroxine absorption by 20-25% through chelation in the gastrointestinal tract.
- St. John's Wort × WarfarinContraindicatedSt. John's Wort is a potent inducer of CYP3A4, CYP2C9, and P-glycoprotein, which dramatically accelerates warfarin metabolism…
- L-Theanine × Magnesium GlycinateSynergyL-theanine and magnesium are both studied for relaxation-related markers, but direct combination evidence is limited.
- Copper × ZincCautionChronic high-dose zinc supplementation (>40mg/day) can induce copper deficiency by upregulating metallothionein
- Iron × ZincConflictIron and zinc compete for the same absorption pathways when taken together in supplement form.
- Magnesium Glycinate × Vitamin D3SynergyMagnesium is essential for vitamin D metabolism. It's required for the enzymes that convert D3 to its active form calcitriol.
- Coenzyme Q10 × Fish OilSynergyCoQ10 is fat-soluble and absorption increases 3-fold when taken with dietary fat. Fish oil provides the ideal fat vehicle.
Most-paired substances
20- St. John's Wort113 pairs
- Magnesium Glycinate98 pairs
- Iron95 pairs
- Berberine94 pairs
- Fish Oil88 pairs
- Calcium80 pairs
- Melatonin79 pairs
- Potassium75 pairs
- Vitamin D373 pairs
- Zinc71 pairs
- Vitamin C70 pairs
- Ginkgo Biloba67 pairs
- Alcohol66 pairs
- Probiotics61 pairs
- Coenzyme Q1056 pairs
- Garlic Extract56 pairs
- Alpha-Lipoic Acid55 pairs
- Quercetin51 pairs
- Ashwagandha51 pairs
- 5-HTP50 pairs
Nothing here matches that filter. Use the exact-pair checker above for the full 2,517-pair database.
Methodology
Source records and evidence limits.
Each row shows its attached sources, with PMIDs where available. A source may support one ingredient or a mechanism without testing the exact pair. Acceptance criteria and evidence tiers are documented in the methodology.