NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Quercetin

Herb ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Plant flavonoid studied for allergy, blood pressure, and cardiometabolic markers. Human senolytic evidence comes from dasatinib plus quercetin combinations, not quercetin alone.

Evidence tier
Moderate
Indexed sources
21 2010–2026
Interactions
0
Cost / month
$4.50 budget
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Quercetin is a herb most often used for immune support, allergy relief, anti-inflammatory. NutriStack rates the overall evidence as moderate. A typical adult dose is 500–1,000 mg daily, commonly taken as quercetin phytosome (enhanced bioavailability) or with bromelain. This profile indexes 21 sources.

What it's good for
  • Immune support16,17
  • Allergy relief13
  • Anti-inflammatory16,2
  • Cardiometabolic marker support7,4
  • Cardiovascular health
What to watch for
  • Headache
  • GI upset
  • Tingling sensation
  • Antibiotics (quinolones)
  • Cyclosporine

The bottom line

Evidence rating moderate. Most-documented uses: immune support, allergy relief, anti-inflammatory. 21 sources indexed (2010–2026), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Acts as an antioxidant flavonoid and may modulate mast cell activity and inflammatory signaling. Proposed zinc-ionophore and senolytic effects are mainly preclinical or combination-therapy findings, so quercetin-alone human effects are not established.16,2

Class
Flavonoid
Found in food
Onions, Apples, Berries
Low-status signs
Not applicable
Absorption
Water-soluble; take with food
Dosing

Dosing & protocol.

Common range
500–1,000 mg daily
Recommended form
Quercetin phytosome (enhanced bioavailability) or with bromelain

Poor bioavailability; take with bromelain or in phytosome form. Synergizes with vitamin C.3,4

Cost

What it actually costs.

Real-world pricing across three quality tiers. Assumes Quercetin Dihydrate.

BudgetBest value
$4.50 /mo
$0.15 per dose
Mid
$8.40 /mo
$0.28 per dose
Premium
$15.00 /mo
$0.50 per dose

Assumes about 500-1,000 mg/day. Liposomal or phytosome delivery systems explain most premium pricing in this category. Updated 2026-04-02.

From food

The same dose, as food.

How much you'd eat to match a supplemental dose.

500 mg quercetin
Several onions plus apples and capers

Capers are one of the richest food sources, but supplement-style intakes are still hard to reach daily.

100 mg quercetin
About 1 onion plus 1 apple

Food meaningfully contributes even when you do not supplement.

Safety

Full safety detail.

Side effects

  • Headache
  • GI upset
  • Tingling sensation

Contraindications

  • Antibiotics (quinolones)
  • Cyclosporine
  • May interact with CYP enzymes
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

12

Randomized controlled trials

3

Reviews & position papers

2
  • 16Quercetin and Its Anti-Allergic Immune ResponsePMIDMlcek J et al. · Molecules · 2016

    Quercetin inhibits mast cell degranulation, reduces histamine and pro-inflammatory cytokines, and restores Th1/Th2 balance.

  • 17Quercetin and its anti-allergic immune response: a reviewMlcek J, Jurikova T, Skrovankova S et al. · Molecules · 2016

Mechanistic & preclinical

2
  • 18Quercetin inhibits SARS-CoV-2 3CLpro activity: an in silico and in vitro studyAbian O, Ortega-Alarcon D, Jimenez-Alesanco A et al. · Int J Biol Macromol · 2020
  • 19Quercetin reduces endothelial dysfunction and atherosclerosis in ApoE-knockout miceLoke WM, Proudfoot JM, Hodgson JM et al. · J Nutr · 2010

Reference material

2
FAQ

Common questions.

Quick answers about Quercetin, drawn from the data on this page.

What is Quercetin?

Plant flavonoid studied for allergy, blood pressure, and cardiometabolic markers. Human senolytic evidence comes from dasatinib plus quercetin combinations, not quercetin alone.

What is Quercetin used for?

Commonly cited benefits of Quercetin include: Immune support; Allergy relief; Anti-inflammatory; Cardiometabolic marker support; Cardiovascular health. NutriStack rates the overall evidence as moderate.

What is a typical dose of Quercetin?

A typical adult dose of Quercetin is 500–1,000 mg daily. The commonly recommended form is Quercetin phytosome (enhanced bioavailability) or with bromelain. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Quercetin?

Reported side effects include headache, gi upset, tingling sensation. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Quercetin?

NutriStack rates this as Moderate, meaning several aligned RCTs or one large RCT plus supporting reviews. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Quercetin in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.