NutriStack
Supplement / Amino Acid
5-HTP
Direct precursor to serotonin, bypassing the rate-limiting tryptophan hydroxylase step. Effective for mood, sleep, and appetite regulation.
- Evidence
- Moderate
- Class
- Serotonin Precursor
Supplements and substance safety, indexed.
Browse 164 public supplement and substance profiles with evidence ratings, safety notes, interactions, and source links.
Directory
Supplements and substance safety, A to Z.
Profiles are listed alphabetically. Each one opens to the full evidence dossier, interaction list, and source links.
Supplement / Amino Acid
Acetyl-L-Carnitine
Acetylated form of L-carnitine that crosses the blood-brain barrier for cognitive support.
- Evidence
- Moderate
- Class
- Amino Acid Derivative
Supplement / Other
Activated Charcoal
Highly porous carbon used for acute toxin binding and occasional digestive support.
- Evidence
- Strong
- Class
- Adsorbent
Substance safety / Other
Alcohol
Alcohol is not supported by NutriStack. Safety information only.
- Evidence
- Insufficient
- Class
- Depressant
Supplement / Other
Alpha-GPC
Highly bioavailable choline source that rapidly crosses the blood-brain barrier. Enhances acetylcholine production for memory, focus, and athletic power output.
- Evidence
- Moderate
- Class
- Nootropic
Supplement / Antioxidant
Alpha-Lipoic Acid
Unique antioxidant that works in both water and fat environments. Regenerates other antioxidants (vitamins C, E, glutathione, CoQ10). Powerful support for blood sugar and nerve health.
- Evidence
- Moderate
- Class
- Universal Antioxidant
Supplement / Other
Apigenin
A calming flavonoid found in chamomile. Popularized by neuroscientist Andrew Huberman as a sleep aid. Also has anti-cancer and neuroprotective research.
- Evidence
- Emerging
- Class
- Flavonoid
Supplement / Herb
Artemisinin
Nobel Prize-winning compound from sweet wormwood with antimalarial and anticancer research.
- Evidence
- Moderate
- Class
- Antimalarial Herb
Supplement / Adaptogen
Ashwagandha
Ayurvedic adaptogenic herb studied for stress, cortisol-related wellness markers, sleep quality, strength/recovery, and thyroid-related markers in selected populations.
- Evidence
- Moderate
- Class
- Ayurvedic Adaptogen
Supplement / Antioxidant
Astaxanthin
The most powerful carotenoid antioxidant, 6,000x more effective than vitamin C at quenching singlet oxygen (a specific lab assay, not general potency). Gives salmon and flamingos their pink color....
- Evidence
- Moderate
- Class
- Carotenoid
Supplement / Herb
Bacopa Monnieri
Ayurvedic herb with strong evidence for memory enhancement and cognitive function.
- Evidence
- Strong
- Class
- Ayurvedic Adaptogenic Herb
Supplement / Amino Acid
BCAAs
Three essential amino acids (leucine, isoleucine, valine) that stimulate muscle protein synthesis.
- Evidence
- Moderate
- Class
- Essential Amino Acids
Supplement / Other
Bee Pollen
Nutrient-dense bee-collected pollen product; clinical benefits are not well established and allergic reactions can be serious.
- Evidence
- Insufficient
- Class
- Bee Product
Supplement / Herb
Berberine
Plant alkaloid with remarkable metabolic effects, often compared to metformin. Potent for blood sugar management, cholesterol, and gut health.
- Evidence
- Strong
- Class
- Metabolic Herb
Supplement / Herb
Berberine HCl
Enhanced form of berberine with better bioavailability for metabolic support.
- Evidence
- Strong
- Class
- Metabolic Alkaloid
Supplement / Amino Acid
Beta-Alanine
Precursor to carnosine, buffering muscle acidity during high-intensity exercise.
- Evidence
- Strong
- Class
- Non-Proteinogenic Amino Acid
Supplement / Other
Beta-Carotene
Orange carotenoid that converts to vitamin A as needed, safer than preformed retinol.
- Evidence
- Moderate
- Class
- Carotenoid
Supplement / Other
Betaine HCL
Supplemental hydrochloric acid for people with low stomach acid (hypochlorhydria).
- Evidence
- Emerging
- Class
- Digestive Support
Supplement / Herb
Black Cohosh
North American herb used for menopause symptom relief, especially hot flashes.
- Evidence
- Moderate
- Class
- Women's Health Herb
Supplement / Herb
Black Seed Oil
Traditional Middle Eastern remedy with broad immune-modulatory and anti-inflammatory effects.
- Evidence
- Emerging
- Class
- Traditional Medicinal Oil
Supplement / Mineral
Boron
Trace mineral studied for bone-mineral, vitamin D, magnesium, and selected hormone-marker contexts.
- Evidence
- Emerging
- Class
- Trace Mineral
Supplement / Herb
Boswellia
Resin extract with potent anti-inflammatory properties, especially for joints.
- Evidence
- Strong
- Class
- Anti-Inflammatory Herb
Supplement / Other
Bromelain
Proteolytic enzyme from pineapple with anti-inflammatory and digestive benefits.
- Evidence
- Moderate
- Class
- Proteolytic Enzyme
Supplement / Mineral
Calcium
The most abundant mineral in the body, critical for bone health, muscle contraction, nerve signaling, and blood clotting.
- Evidence
- Strong
- Class
- Essential Mineral
Substance safety / Other
Cannabis (THC-Dominant)
Cannabis (THC-dominant) is not supported by NutriStack. Safety information only.
- Evidence
- Insufficient
- Class
- Cannabinoid
Supplement / Herb
Cat's Claw
Amazonian vine used for immune support and joint inflammation.
- Evidence
- Emerging
- Class
- Anti-Inflammatory Vine
Supplement / Herb
Chaga
Birch tree fungus rich in antioxidants and immune-modulating compounds.
- Evidence
- Emerging
- Class
- Medicinal Mushroom
Supplement / Other
Chlorella
Single-celled green algae known for heavy metal chelation and nutrient density.
- Evidence
- Moderate
- Class
- Green Algae
Supplement / Other
Chondroitin
Glycosaminoglycan found in cartilage, often paired with glucosamine.
- Evidence
- Moderate
- Class
- Joint Support Compound
Supplement / Mineral
Chromium
Trace mineral that enhances insulin sensitivity and supports healthy blood sugar metabolism. Popular supplement for glucose management and body composition.
- Evidence
- Emerging
- Class
- Trace Mineral
Supplement / Other
Citicoline
Premium choline source that provides both choline (for acetylcholine synthesis) and cytidine (converts to uridine for brain phospholipid synthesis). Superior nootropic to basic choline.
- Evidence
- Moderate
- Class
- Nootropic
Supplement / Omega/Fatty Acid
CLA
Naturally occurring trans fat found in grass-fed meat and dairy with body composition benefits.
- Evidence
- Moderate
- Class
- Trans Fatty Acid Isomer
Substance safety / Other
Cocaine
Cocaine is not supported by NutriStack. Safety information only.
- Evidence
- Insufficient
- Class
- Stimulant
Supplement / Antioxidant
Coenzyme Q10
Essential component of the mitochondrial electron transport chain. Production declines significantly with age and statin use. Critical for heart, brain, and cellular energy.
- Evidence
- Strong
- Class
- Mitochondrial Support
Supplement / Other
Coenzyme Q10 Ubiquinol
The reduced, active antioxidant form of CoQ10, 3-8x better absorbed than ubiquinone.
- Evidence
- Strong
- Class
- Active CoQ10 Form
Supplement / Amino Acid
Collagen Peptides
Hydrolyzed collagen provides bioactive peptides that stimulate the body's own collagen production. Supports skin elasticity, joint health, and gut lining integrity.
- Evidence
- Moderate
- Class
- Protein
Supplement / Other
Colostrum
First milk containing concentrated immunoglobulins, growth factors, and lactoferrin.
- Evidence
- Emerging
- Class
- Immune Protein Complex
Supplement / Mineral
Copper
Essential trace mineral for iron metabolism, connective tissue formation, and antioxidant defense. Must be balanced with zinc intake.
- Evidence
- Moderate
- Class
- Trace Mineral
Supplement / Adaptogen
Cordyceps
Energy-boosting medicinal mushroom traditionally used in Tibetan and Chinese medicine. Enhances oxygen utilization, ATP production, and physical performance.
- Evidence
- Emerging
- Class
- Medicinal Mushroom
Supplement / Amino Acid
Creatine
One of the most researched supplements in history. Primarily known for athletic performance, but emerging evidence strongly supports cognitive benefits, especially under stress or sleep deprivation.
- Evidence
- Strong
- Class
- Organic Compound
Supplement / Herb
Curcumin Phytosome
Curcumin complexed with phosphatidylcholine for 29x better absorption than standard curcumin.
- Evidence
- Strong
- Class
- Enhanced Curcumin
Supplement / Amino Acid
D-Aspartic Acid
Amino acid isomer studied for male fertility and testosterone, with inconsistent human evidence and no reliable testosterone benefit in healthy or resistance-trained men.
- Evidence
- Emerging
- Class
- Non-Essential Amino Acid
Supplement / Other
D-Mannose
Natural sugar that prevents UTI-causing bacteria from adhering to urinary tract walls.
- Evidence
- Moderate
- Class
- Simple Sugar
Supplement / Hormone
DHEA
Adrenal hormone precursor that declines with age and can raise downstream androgen and estrogen activity. Use should be guided by labs and clinician oversight, especially in hormone-sensitive or...
- Evidence
- Moderate
- Class
- Hormone Precursor
Supplement / Enzyme
Digestive Enzymes
Blend of enzymes that break down proteins, fats, carbohydrates, and fiber. Helpful for those with low enzyme production, digestive discomfort, or when eating enzyme-poor cooked foods.
- Evidence
- Moderate
- Class
- Digestive Support
Supplement / Other
DIM
Compound from cruciferous vegetables studied for estrogen metabolite patterns. It is not a stand-alone hormone therapy and has important drug-interaction and hormone-sensitive cancer cautions.
- Evidence
- Emerging
- Class
- Cruciferous Compound
Supplement / Herb
Echinacea
Popular immune-stimulating herb used at the onset of colds.
- Evidence
- Moderate
- Class
- Immune-Stimulating Herb
Supplement / Herb
Elderberry
Rich in anthocyanins with antiviral properties, popular for cold and flu support.
- Evidence
- Moderate
- Class
- Antiviral Berry
Supplement / Other
Elderberry Zinc Lozenges
Popular cold-fighting combination of zinc and elderberry for acute immune support.
- Evidence
- Moderate
- Class
- Combination Supplement
Supplement / Omega/Fatty Acid
Evening Primrose Oil
Rich in gamma-linolenic acid (GLA) for hormonal balance and skin health.
- Evidence
- Moderate
- Class
- Omega-6 Fatty Acid
Supplement / Herb
Fenugreek
Seed extract used for blood sugar control, testosterone support, and milk production.
- Evidence
- Moderate
- Class
- Galactagogue & Testosterone Herb
Supplement / Omega/Fatty Acid
Fish Oil
The most important essential fatty acid supplement. EPA and DHA omega-3s are critical for brain function, heart health, and systemic inflammation control.
- Evidence
- Strong
- Class
- Essential Fatty Acid
Supplement / Omega/Fatty Acid
Fish Oil Triple Strength
High-potency fish oil with 75-90% omega-3 concentration for fewer pills and better results.
- Evidence
- Strong
- Class
- Concentrated Omega-3
Supplement / Omega/Fatty Acid
Flaxseed Oil
Richest plant source of alpha-linolenic acid (ALA), a precursor to EPA/DHA.
- Evidence
- Moderate
- Class
- Plant-Based Omega-3
Supplement / Amino Acid
GABA
Primary inhibitory neurotransmitter supplement for relaxation and sleep.
- Evidence
- Emerging
- Class
- Inhibitory Neurotransmitter
Supplement / Herb
Garlic Extract
Aged garlic extract supports cardiovascular health and immune function.
- Evidence
- Strong
- Class
- Cardiovascular Herb
Supplement / Herb
Ginger Extract
Warming root studied for nausea, digestion, and inflammatory-marker contexts.
- Evidence
- Strong
- Class
- Anti-Nausea Herb
Supplement / Herb
Ginkgo Biloba
One of the oldest living tree species, used for cognitive function and circulation.
- Evidence
- Moderate
- Class
- Cerebrovascular Herb
Supplement / Other
Glucosamine
Amino sugar building block for cartilage repair and joint health.
- Evidence
- Moderate
- Class
- Joint Support Compound
Supplement / Amino Acid
Glycine
The simplest amino acid with surprisingly powerful effects on sleep quality, collagen synthesis, and neuroprotection. A key component of glutathione.
- Evidence
- Moderate
- Class
- Non-Essential Amino Acid
Supplement / Herb
Grape Seed Extract
Rich in oligomeric proanthocyanidins (OPCs) for cardiovascular and antioxidant support.
- Evidence
- Moderate
- Class
- Polyphenol Extract
Supplement / Herb
Green Tea Extract
Rich in EGCG catechins for antioxidant, metabolic, and cognitive benefits.
- Evidence
- Strong
- Class
- Polyphenol Extract
Supplement / Amino Acid
HMB
Metabolite of leucine that reduces muscle protein breakdown.
- Evidence
- Moderate
- Class
- Leucine Metabolite
Supplement / Herb
Holy Basil/Tulsi
Sacred Ayurvedic herb for stress adaptation and metabolic balance.
- Evidence
- Moderate
- Class
- Ayurvedic Adaptogen
Supplement / Other
Hyaluronic Acid
Key molecule for skin hydration, joint lubrication, and tissue repair.
- Evidence
- Moderate
- Class
- Glycosaminoglycan
Supplement / Other
Inositol
Sugar alcohol involved in insulin signaling and neurotransmitter function.
- Evidence
- Strong
- Class
- B-Vitamin Relative
Supplement / Mineral
Iodine
Essential for thyroid hormone production. Deficiency is the leading cause of preventable intellectual disability worldwide. Many people are mildly deficient.
- Evidence
- Strong
- Class
- Trace Mineral
Supplement / Mineral
Iron
Essential for oxygen transport via hemoglobin, energy production, and immune function. Most common nutritional deficiency worldwide, especially in women.
- Evidence
- Strong
- Class
- Essential Mineral
Supplement / Mineral
Iron Bisglycinate
Gentle, highly bioavailable iron form that causes less GI distress than other forms.
- Evidence
- Strong
- Class
- Iron Form
Substance safety / Other
Ketamine
Ketamine is not supported by NutriStack. Safety information only.
- Evidence
- Insufficient
- Class
- Dissociative
Supplement / Omega/Fatty Acid
Krill Oil
EPA/DHA bound to phospholipids for superior bioavailability. Also contains astaxanthin, a powerful antioxidant. Often better tolerated than fish oil with no fishy burps.
- Evidence
- Moderate
- Class
- Essential Fatty Acid
Supplement / Amino Acid
L-Arginine
Precursor to nitric oxide, supporting blood flow and cardiovascular health.
- Evidence
- Strong
- Class
- Conditionally Essential Amino Acid
Supplement / Amino Acid
L-Carnitine
Transports long-chain fatty acids into mitochondria for energy production.
- Evidence
- Moderate
- Class
- Amino Acid Derivative
Supplement / Amino Acid
L-Citrulline
Converts to L-arginine in the kidneys, providing sustained nitric oxide production.
- Evidence
- Strong
- Class
- Non-Essential Amino Acid
Supplement / Amino Acid
L-Glutamine
Most abundant amino acid in the body, critical for gut health and immune function.
- Evidence
- Moderate
- Class
- Conditionally Essential Amino Acid
Supplement / Amino Acid
L-Glutathione
The body's master antioxidant, critical for detoxification and immune function.
- Evidence
- Moderate
- Class
- Tripeptide Antioxidant
Supplement / Amino Acid
L-Lysine
Essential amino acid important for collagen synthesis, calcium absorption, and antiviral activity.
- Evidence
- Moderate
- Class
- Essential Amino Acid
Supplement / Amino Acid
L-Methionine
Essential sulfur-containing amino acid, precursor to SAMe and cysteine.
- Evidence
- Moderate
- Class
- Essential Amino Acid
Supplement / Amino Acid
L-Theanine
Unique amino acid found primarily in green tea. Promotes calm alertness without drowsiness. Synergizes exceptionally well with caffeine for focused energy.
- Evidence
- Moderate
- Class
- Non-Essential Amino Acid
Supplement / Amino Acid
L-Tryptophan
Essential amino acid precursor to serotonin and melatonin.
- Evidence
- Moderate
- Class
- Essential Amino Acid
Supplement / Amino Acid
L-Tyrosine
Precursor to dopamine, norepinephrine, and epinephrine. Excellent for maintaining cognitive performance under stress, sleep deprivation, or multi-tasking demands.
- Evidence
- Moderate
- Class
- Non-Essential Amino Acid
Supplement / Probiotic
Lactobacillus Rhamnosus
One of the most researched probiotic strains for gut and immune health.
- Evidence
- Strong
- Class
- Specific Probiotic Strain
Supplement / Adaptogen
Lion's Mane
Unique medicinal mushroom with preclinically demonstrated nerve growth factor (NGF) stimulating properties. The premier nootropic mushroom for cognitive enhancement and neuroprotection.
- Evidence
- Emerging
- Class
- Medicinal Mushroom
Supplement / Mineral
Lithium Orotate
Low-dose lithium supplement for neuroprotection and mood support.
- Evidence
- Insufficient
- Class
- Trace Mineral
Supplement / Other
Lutein
Macular carotenoid essential for eye health and blue light protection.
- Evidence
- Strong
- Class
- Carotenoid
Supplement / Other
Lycopene
Red carotenoid pigment with potent antioxidant properties, especially for prostate health.
- Evidence
- Moderate
- Class
- Carotenoid
Supplement / Herb
Maca Root
Peruvian root vegetable used for energy, libido, and hormonal balance.
- Evidence
- Moderate
- Class
- Adaptogenic Root
Supplement / Mineral
Magnesium Citrate
Well-absorbed magnesium form with mild laxative properties.
- Evidence
- Strong
- Class
- Magnesium Form
Supplement / Mineral
Magnesium Glycinate
One of the most bioavailable and gentle forms of magnesium (Mg citrate is comparably bioavailable). Excellent for relaxation, sleep, and muscle recovery. Less likely to cause GI issues than other...
- Evidence
- Strong
- Class
- Chelated Mineral
Supplement / Mineral
Magnesium L-Threonate
The most effective form studied for raising brain magnesium levels (all Mg forms cross BBB to some degree). Developed at MIT specifically for cognitive enhancement and brain health.
- Evidence
- Emerging
- Class
- Chelated Mineral
Supplement / Mineral
Magnesium Malate
Magnesium combined with malic acid, targeted for energy and fibromyalgia support.
- Evidence
- Moderate
- Class
- Magnesium Form
Supplement / Mineral
Magnesium Taurate
Magnesium chelated with taurine, specifically targeted for cardiovascular support.
- Evidence
- Moderate
- Class
- Magnesium Form
Supplement / Mineral
Manganese
Essential trace mineral for bone formation, blood clotting, and metabolism.
- Evidence
- Moderate
- Class
- Trace Mineral
Supplement / Omega/Fatty Acid
MCT Oil
Rapidly absorbed fatty acids that provide quick energy and support ketone production.
- Evidence
- Moderate
- Class
- Medium-Chain Fatty Acid
Substance safety / Other
MDMA
MDMA is not supported by NutriStack. Safety information only.
- Evidence
- Insufficient
- Class
- Empathogen / Stimulant
Supplement / Hormone
Melatonin
The body's primary sleep-regulating hormone. Also a potent antioxidant with neuroprotective properties. Most people use doses far higher than needed.
- Evidence
- Strong
- Class
- Sleep Hormone
Supplement / Vitamin
Methylcobalamin
The active, methylated coenzyme form of vitamin B12, bypasses conversion steps.
- Evidence
- Strong
- Class
- Active B12 Form
Supplement / Vitamin
Methylfolate
The active, methylated form of folate, essential for those with MTHFR variants.
- Evidence
- Strong
- Class
- Active Folate
Supplement / Herb
Milk Thistle
The premier liver-protective herb, used for over 2,000 years. Silymarin complex protects hepatocytes from toxin damage and supports liver regeneration.
- Evidence
- Moderate
- Class
- Liver-Support Herb
Supplement / Mineral
Molybdenum
Trace mineral essential for enzyme function in sulfite and purine metabolism.
- Evidence
- Moderate
- Class
- Trace Mineral
Supplement / Herb
Moringa
Tropical tree leaf with exceptional nutrient density, often called the 'miracle tree.'
- Evidence
- Emerging
- Class
- Nutrient-Dense Superfood Herb
Supplement / Other
MSM
Organic sulfur compound for joint health and connective tissue support.
- Evidence
- Moderate
- Class
- Sulfur Compound
Supplement / Amino Acid
NAC
The most effective oral precursor to glutathione, the body's master antioxidant. Powerful liver protectant, mucolytic, and mental health support compound.
- Evidence
- Strong
- Class
- Modified Amino Acid
Supplement / Other
Nattokinase
Enzyme from fermented soybeans (natto) with blood clot-dissolving properties.
- Evidence
- Moderate
- Class
- Fibrinolytic Enzyme
Substance safety / Other
Nicotine
Nicotine is not supported by NutriStack. Safety information only.
- Evidence
- Insufficient
- Class
- Stimulant
Supplement / Other
NMN
Direct precursor to NAD+, the critical coenzyme that declines with age. At the forefront of longevity research for cellular rejuvenation and anti-aging.
- Evidence
- Emerging
- Class
- Longevity Compound
Supplement / Herb
Olive Leaf Extract
Rich in oleuropein with antimicrobial, antioxidant, and cardiovascular benefits.
- Evidence
- Emerging
- Class
- Antimicrobial Polyphenol
Supplement / Omega/Fatty Acid
Omega-7
Uncommon omega fatty acid supporting mucous membrane health and metabolic function.
- Evidence
- Emerging
- Class
- Monounsaturated Fatty Acid
Supplement / Other
Ox Bile
Supplemental bile acids for those with gallbladder removal or bile insufficiency.
- Evidence
- Moderate
- Class
- Digestive Support
Supplement / Herb
Passionflower
Gentle calming herb for anxiety and sleep with fewer side effects than valerian.
- Evidence
- Moderate
- Class
- Anxiolytic Herb
Supplement / Omega/Fatty Acid
Phosphatidylcholine
Major phospholipid in cell membranes and a choline source for brain health.
- Evidence
- Moderate
- Class
- Phospholipid
Supplement / Other
Phosphatidylserine
Phospholipid found in brain cell membranes and studied for memory, attention, exercise-stress, and cortisol-response markers.
- Evidence
- Moderate
- Class
- Phospholipid
Supplement / Herb
Pine Bark Extract
French maritime pine bark extract with potent antioxidant and blood flow benefits.
- Evidence
- Moderate
- Class
- Polyphenol Extract
Supplement / Mineral
Potassium
Crucial electrolyte for heart rhythm, muscle contraction, nerve signaling, and blood pressure regulation. Most people don't get enough from diet alone.
- Evidence
- Strong
- Class
- Essential Mineral
Supplement / Other
PQQ
Novel cofactor that promotes mitochondrial biogenesis, creating new mitochondria.
- Evidence
- Emerging
- Class
- Mitochondrial Cofactor
Supplement / Hormone
Pregnenolone
Precursor to all steroid hormones, the starting point of the steroidogenic pathway.
- Evidence
- Emerging
- Class
- Master Hormone Precursor
Supplement / Probiotic
Probiotics
Live beneficial bacteria that colonize the gut microbiome. Support digestion, immune function, mental health (gut-brain axis), and nutrient synthesis.
- Evidence
- Strong
- Class
- Gut Health
Substance safety / Other
Psilocybin
Psilocybin is not supported by NutriStack. Safety information only.
- Evidence
- Insufficient
- Class
- Psychedelic
Supplement / Other
Psyllium Husk
Soluble fiber supplement for digestive regularity and cholesterol reduction.
- Evidence
- Strong
- Class
- Soluble Fiber
Supplement / Herb
Quercetin
Plant flavonoid studied for allergy, blood pressure, and cardiometabolic markers. Human senolytic evidence comes from dasatinib plus quercetin combinations, not quercetin alone.
- Evidence
- Moderate
- Class
- Flavonoid
Supplement / Adaptogen
Reishi
The 'mushroom of immortality' in Traditional Chinese Medicine. Premier immune-modulating mushroom with calming, sleep-promoting properties. Ideal evening adaptogen.
- Evidence
- Moderate
- Class
- Medicinal Mushroom
Supplement / Herb
Resveratrol
Polyphenol from red wine and grapes studied for metabolic, vascular, and oxidative-stress markers. Best taken with a fat source for absorption.
- Evidence
- Emerging
- Class
- Polyphenol
Supplement / Adaptogen
Rhodiola Rosea
Arctic adaptogen used for centuries in Scandinavian and Russian traditional medicine. Excels at combating fatigue, enhancing mental performance, and improving stress resilience.
- Evidence
- Moderate
- Class
- Nordic Adaptogen
Supplement / Other
Royal Jelly
Nutrient-rich bee secretion with limited human evidence for selected metabolic and menopausal outcomes; allergic reactions can be severe.
- Evidence
- Emerging
- Class
- Bee Product
Supplement / Probiotic
Saccharomyces Boulardii
Beneficial probiotic yeast resistant to antibiotics, ideal for gut support during antibiotic use.
- Evidence
- Strong
- Class
- Probiotic Yeast
Supplement / Other
SAMe
Universal methyl donor involved in over 100 methylation reactions in the body.
- Evidence
- Strong
- Class
- Methyl Donor
Supplement / Herb
Saw Palmetto
Berry extract traditionally used for prostate and urinary symptoms; larger reviews find mixed-to-negative evidence for BPH symptom relief.
- Evidence
- Insufficient
- Class
- Prostate Support Herb
Supplement / Herb
Schisandra
Adaptogenic berry used in TCM for liver protection and stress resilience.
- Evidence
- Moderate
- Class
- Adaptogenic Berry
Supplement / Mineral
Selenium
Essential trace mineral crucial for thyroid function, antioxidant defense, and immune health. Narrow therapeutic window, both deficiency and excess are harmful.
- Evidence
- Strong
- Class
- Trace Mineral
Supplement / Other
Serrapeptase
Silkworm-derived enzyme with fibrinolytic and anti-inflammatory properties.
- Evidence
- Emerging
- Class
- Proteolytic Enzyme
Supplement / Other
Shilajit
Ancient Himalayan mineral resin containing fulvic acid and 80+ trace minerals.
- Evidence
- Emerging
- Class
- Ayurvedic Mineral Complex
Supplement / Mineral
Silicon
Trace mineral important for bone, skin, hair, and nail health.
- Evidence
- Emerging
- Class
- Trace Mineral
Supplement / Other
Spirulina
Nutrient-dense blue-green algae with high protein and antioxidant content.
- Evidence
- Moderate
- Class
- Blue-Green Algae
Supplement / Herb
St. John's Wort
Widely used herbal antidepressant with one of the most dangerous supplement-drug interaction profiles. Potent CYP3A4 and P-glycoprotein inducer, reduces effectiveness of many critical medications.
- Evidence
- Moderate
- Class
- Mood Support Herb
Supplement / Mineral
Strontium
Trace element that supports bone density by stimulating osteoblasts and inhibiting osteoclasts.
- Evidence
- Moderate
- Class
- Bone-Support Mineral
Supplement / Other
Sulforaphane
Potent Nrf2 activator from broccoli sprouts for detoxification and cellular protection.
- Evidence
- Moderate
- Class
- Cruciferous Compound
Supplement / Amino Acid
Taurine
Sulfur-containing amino acid abundant in heart, brain, and retina. Supports cardiovascular and neural function.
- Evidence
- Moderate
- Class
- Conditionally Essential Amino Acid
Supplement / Herb
Tongkat Ali
Malaysian herb researched for testosterone support and stress reduction.
- Evidence
- Moderate
- Class
- Testosterone Support Herb
Supplement / Herb
Tribulus Terrestris
Traditional herb marketed for testosterone, though evidence is mixed.
- Evidence
- Emerging
- Class
- Testosterone Support Herb
Supplement / Herb
Turkey Tail
Colorful bracket fungus with strong immune-modulating research, especially PSK/PSP.
- Evidence
- Moderate
- Class
- Medicinal Mushroom
Supplement / Herb
Turmeric/Curcumin
The golden spice with powerful anti-inflammatory and antioxidant properties. Curcumin is the active compound, but has poor bioavailability without enhancers like piperine.
- Evidence
- Strong
- Class
- Anti-Inflammatory Herb
Supplement / Herb
Valerian Root
Traditional herbal sedative for sleep and anxiety relief.
- Evidence
- Moderate
- Class
- Sedative Herb
Supplement / Mineral
Vanadium
Ultra-trace mineral that mimics insulin action for blood sugar support.
- Evidence
- Emerging
- Class
- Ultra-Trace Mineral
Supplement / Vitamin
Vitamin A
Essential for vision, immune function, skin health, and cell differentiation. Available as preformed retinol or provitamin A (beta-carotene).
- Evidence
- Strong
- Class
- Fat-Soluble Vitamin
Supplement / Vitamin
Vitamin B1
Essential for energy metabolism, nerve function, and carbohydrate metabolism. First B vitamin discovered.
- Evidence
- Strong
- Class
- B Vitamin
Supplement / Vitamin
Vitamin B12
Essential for nerve function, red blood cell formation, DNA synthesis, and methylation. Common deficiency in vegans and older adults due to absorption issues.
- Evidence
- Strong
- Class
- B Vitamin
Supplement / Vitamin
Vitamin B2
Essential for energy production, cellular function, and metabolism of fats, drugs, and steroids. Also important for maintaining healthy skin and eyes.
- Evidence
- Strong
- Class
- B Vitamin
Supplement / Vitamin
Vitamin B3
Critical for NAD+ production, energy metabolism, DNA repair, and cellular signaling. Available as niacin (causes flushing) or niacinamide (no flush).
- Evidence
- Strong
- Class
- B Vitamin
Supplement / Vitamin
Vitamin B5
Essential for synthesis of coenzyme A (CoA), which is involved in hundreds of metabolic pathways including fatty acid synthesis and energy production.
- Evidence
- Moderate
- Class
- B Vitamin
Supplement / Vitamin
Vitamin B6
Involved in over 100 enzyme reactions, primarily in amino acid metabolism. Critical for neurotransmitter synthesis, hemoglobin production, and immune function.
- Evidence
- Strong
- Class
- B Vitamin
Supplement / Vitamin
Vitamin B7
Known as the 'beauty vitamin' for its role in hair, skin, and nail health. Also essential for macronutrient metabolism.
- Evidence
- Moderate
- Class
- B Vitamin
Supplement / Vitamin
Vitamin B9
Essential for DNA synthesis, cell division, and methylation. Critical during pregnancy for neural tube development. Methylfolate is the bioactive form.
- Evidence
- Strong
- Class
- B Vitamin
Supplement / Vitamin
Vitamin C
A powerful antioxidant essential for collagen synthesis, immune function, and iron absorption. Humans cannot synthesize it and must obtain it from diet or supplements.
- Evidence
- Strong
- Class
- Water-Soluble Vitamin
Supplement / Vitamin
Vitamin C Liposomal
Vitamin C encapsulated in phospholipid liposomes for dramatically improved absorption.
- Evidence
- Strong
- Class
- Enhanced Vitamin C
Supplement / Vitamin
Vitamin D2
Plant-derived form of vitamin D, less potent than D3 but suitable for vegans.
- Evidence
- Moderate
- Class
- Fat-Soluble Vitamin
Supplement / Vitamin
Vitamin D3
The sunshine vitamin, essential for calcium absorption, bone health, immune function, and mood regulation. Most people are deficient, especially in northern latitudes.
- Evidence
- Strong
- Class
- Fat-Soluble Vitamin
Supplement / Vitamin
Vitamin E
A fat-soluble antioxidant that protects cell membranes from oxidative damage. Important for skin health and immune function; cardiovascular outcome benefits from routine supplementation are not...
- Evidence
- Moderate
- Class
- Fat-Soluble Vitamin
Supplement / Vitamin
Vitamin K1
The primary form of vitamin K found in plants, essential for blood clotting. Also supports bone health to a lesser extent than K2.
- Evidence
- Strong
- Class
- Fat-Soluble Vitamin
Supplement / Vitamin
Vitamin K2
Directs calcium to bones and teeth while preventing arterial calcification. Critical partner for vitamin D3 supplementation.
- Evidence
- Strong
- Class
- Fat-Soluble Vitamin
Supplement / Vitamin
Vitamin K2 MK-4
Short-acting form of K2 that reaches bone and brain tissue rapidly.
- Evidence
- Moderate
- Class
- Fat-Soluble Vitamin
Supplement / Other
Zeaxanthin
Partner carotenoid to lutein for comprehensive macular protection.
- Evidence
- Strong
- Class
- Carotenoid
Supplement / Mineral
Zinc
Essential trace mineral involved in immune function, wound healing, DNA synthesis, and testosterone production. Second most abundant trace mineral in the body.
- Evidence
- Strong
- Class
- Trace Mineral
Supplement / Mineral
Zinc Carnosine
Zinc chelated with L-carnosine, specifically targeted for gut lining repair.
- Evidence
- Moderate
- Class
- Zinc Form
Supplement / Mineral
Zinc Picolinate
Highly bioavailable zinc form chelated with picolinic acid.
- Evidence
- Strong
- Class
- Zinc Form