Grape Seed Extract
Herb ·Exploratory record · not publication-reviewed ·Updated September 28, 2026
Rich in oligomeric proanthocyanidins (OPCs) for cardiovascular and antioxidant support.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Grape Seed Extract is a herb most often used for cardiovascular health, antioxidant, skin protection. NutriStack rates the overall evidence as moderate. A typical adult dose is 100-300 mg daily, commonly taken as standardized to 95% opcs. This profile indexes 14 sources.
The bottom line
Evidence rating moderate. Most-documented uses: cardiovascular health, antioxidant, skin protection. 14 sources indexed (2002–2024), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
OPCs stabilize collagen and elastin in blood vessel walls, inhibit LDL oxidation, and modulate endothelial nitric oxide synthase (eNOS) for vasodilation.3,4
Dosing & protocol.
What it actually costs.
Real-world pricing across three quality tiers. Assumes 95% OPC Grape Seed Extract.
Assumes 100-300 mg/day. Vendor basis: NOW/iHerb, Vitacost, Life Extension, and Amazon marketplace; high-OPC extracts set the mid and premium tiers. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Commercial extract concentrates proanthocyanidins far beyond ordinary servings.
Full safety detail.
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
10- 1Grape seed extract and endothelial function: A systematic review and meta-analysis.PMIDRas RT, Zock PL et al. · Clinical Nutrition · 2024
Meta-analysis demonstrated grape seed extract supplementation significantly improved flow-mediated dilation (FMD), a marker of endothelial function.
- 2Effect of grape seed extract supplementation on inflammatory and oxidative stress markers: A systematic review and meta-analysis.PMIDGhalichi F, Ghavipour M et al. · Food & Nutrition Research · 2023
Meta-analysis found grape seed extract significantly reduced CRP, malondialdehyde (MDA), and increased total antioxidant capacity (TAC).
- 3The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysisPMIDFoshati S, Nouripour F, Sadeghi E et al. · Pharmacological research · 2022
Foshati S, Nouripour F, Sadeghi E et al.. The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis. Pharmacological research. 2022
- 4Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the LiteraturePMIDGrohmann T, Litts C, Horgan G et al. · Nutrients · 2021
Grohmann T, Litts C, Horgan G et al.. Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature. Nutrients. 2021
- 5The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta-analysis of controlled trialsPMIDFoshati S, Rouhani MH, Amani R · International journal of clinical practice · 2021
Foshati S, Rouhani MH, Amani R. The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta-analysis of controlled trials. International journal of clinical practice. 2021
- 6The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trialsPMIDAsbaghi O, Nazarian B, Reiner Ž et al. · Phytotherapy research : PTR · 2020
Asbaghi O, Nazarian B, Reiner Ž et al.. The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy research : PTR. 2020
- 7Prevention of dental caries by grape seed extract supplementation: A systematic reviewPMIDDelimont NM, Carlson BN · Nutrition and health · 2020
Delimont NM, Carlson BN. Prevention of dental caries by grape seed extract supplementation: A systematic review. Nutrition and health. 2020
- 8The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trialsPMIDZhang H et al. · Medicine · 2016
GSE significantly reduced systolic BP (-6.08 mmHg) and diastolic BP (-2.80 mmHg); effects more pronounced in younger, obese subjects and those with metabolic disorders.
- 9The Role of Grape Seed Extract in the Treatment of Chemo/Radiotherapy Induced Toxicity: A Systematic Review of Preclinical StudiesPMIDOlaku OO, Ojukwu MO, Zia FZ et al. · Nutrition and cancer · 2015
Olaku OO, Ojukwu MO, Zia FZ et al.. The Role of Grape Seed Extract in the Treatment of Chemo/Radiotherapy Induced Toxicity: A Systematic Review of Preclinical Studies. Nutrition and cancer. 2015
- 10The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trialsPMIDFeringa HH et al. · Journal of the American Dietetic Association · 2011
Nine RCTs (390 participants) showed GSE significantly lowered systolic BP (-1.54 mmHg) and heart rate (-1.42 bpm).
Randomized controlled trials
2- 11Safety assessment of 4-week oral intake of proanthocyanidin-rich grape seed extract in healthy subjectsPMIDSano A et al. · Food and Chemical Toxicology · 2017
Oral intake of grape seed extract up to 2500 mg for 4 weeks was generally safe and well tolerated in healthy humans.
- 12Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humansPMIDNatella F et al. · Journal of Agricultural and Food Chemistry · 2002
GSE supplementation with meals decreased oxidants and increased antioxidant levels in plasma, enhancing resistance to LDL oxidative modification.
Reviews & position papers
1- 13Grape seed extract: having a potential health benefitsPMIDGupta M et al. · Journal of Food Science and Technology · 2020
Antioxidant power of grape seed proanthocyanidins is 20 times greater than vitamin E and 50 times greater than vitamin C.
Mechanistic & preclinical
1- 14Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling in human epidermal keratinocytesPMIDSharma SD et al. · Free Radical Biology and Medicine · 2006
GSE inhibited UVB-induced hydrogen peroxide, lipid peroxidation, protein oxidation, and DNA damage in human keratinocytes.
Common questions.
Quick answers about Grape Seed Extract, drawn from the data on this page.
What is Grape Seed Extract?
Rich in oligomeric proanthocyanidins (OPCs) for cardiovascular and antioxidant support.
What is Grape Seed Extract used for?
Commonly cited benefits of Grape Seed Extract include: Cardiovascular health; Antioxidant; Skin protection; Circulation. NutriStack rates the overall evidence as moderate.
What is a typical dose of Grape Seed Extract?
A typical adult dose of Grape Seed Extract is 100-300 mg daily. The commonly recommended form is Standardized to 95% OPCs. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Grape Seed Extract?
Reported side effects include headache, dizziness, gi upset. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Grape Seed Extract?
NutriStack rates this as Moderate, meaning several aligned RCTs or one large RCT plus supporting reviews. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Grape Seed Extract in NutriStack.
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