NutriStack
Strong
Multiple high-quality RCTs or meta-analyses.
Effect has been replicated in independent randomized trials or pooled in systematic reviews. The biological mechanism is well-understood. The highest tier we assign.
NutriStack Research/Edition 1.0·Updated June 1, 2026·4,682 source records
The data model, evidence grading, interaction methodology, and sourcing behind NutriStack Research.
NutriStack is independently owned.
No manufacturer payments. No affiliate revenue. No celebrity protocols.
Stack Score
Your Stack Score is a weighted 0–100 composite of safety, evidence, routine quality, and stack load. The source code lives in the app.
Composite weights
Safety carries the most weight. Synergy bonuses are capped, and conflicts or contraindications can cap the final score until they are resolved.
What changes the score
The score now reacts to more than pairwise interaction counts. It uses interaction severity and evidence, ingredient evidence tiers, whether doses and timing are filled in, food-context fit, active stack size, and category redundancy.
The in-app Stack screen shows the four dimensions and the current score drivers for the active routine.
A note on the in-app combined score
Earlier versions used a base score plus interaction deltas. The current in-app Stack Score uses the four-part weighted model above, so it can respond to evidence quality, schedule completeness, and stack complexity as well as safety.
Read the Stack Score deep dive → The detailed scoring model, examples, and safety-cap behavior.
Interactions
The interaction database is the heart of the app. Here is exactly what is in it and where every entry came from.
Each interaction row contains
Where the data comes from
Interaction records draw from attached PubMed-indexed studies, reviews, regulatory labels, and curated pharmacology references. A source may support one ingredient, mechanism, or safety concern without testing the exact pair; prescription-pair pages are eligible for search only when the evidence ledger finds a direct human source naming both substances. Citation presence is not the same as clinical review.
Citations include the study text, PMID (for PubMed-indexed studies), and DOI where available. Most rows include the strongest 2–4 studies behind that specific interaction. The full set of source links is browsable at /research/interactions.
Try the free interaction checker → Pick any two of 377 substances and see the documented interaction, the verdict, and the citations.
Read the interactions deep dive → A real row's full JSON, sourcing standards, and five named interactions with PMIDs.
Evidence tiers
Every claim, supplement profile, and interaction carries a tier. Tiers are not letter grades and not stars. Here is what each one means.
Strong
Effect has been replicated in independent randomized trials or pooled in systematic reviews. The biological mechanism is well-understood. The highest tier we assign.
Moderate
Multiple studies point the same direction, often including at least one RCT. Some questions about dose, population, or duration may remain open.
Emerging
Smaller studies, single trials, or strong mechanistic evidence without large-scale confirmation yet. Flagged clearly so hope is not mistaken for proof.
Limited
Only a handful of studies exist, the results disagree, or the study designs were weak. We say so plainly rather than averaging the noise into a confident-sounding score.
Traditional
Centuries of traditional use, often in Ayurveda or TCM, but minimal randomized evidence in modern populations. Reserved for substances with that specific profile.
Read the evidence-tiers deep dive → Explicit criteria per tier, real named examples, the database shape, and the public downgrade policy.
Peptides
A peptide is not automatically a supplement, and popularity is not evidence. NutriStack separates nutritional peptides, FDA-approved peptide drugs, and research-use products before it considers any recommendation.
Browse the research library → Peptide entries use primary sources such as FDA compounding risk tables, DailyMed drug labels, PubMed-indexed trials, and WADA/USADA prohibited-list materials.
Core regulatory sources reviewed for this policy include FDA's compounded bulk-substance safety-risk table, FDA's unapproved GLP-1 warning, DailyMed's Zepbound label, and the 2026 USADA/WADA guide.
Updates
The database ships with the app, and every app update can refresh it.
Conflicts policy
The conflicts of interest we will not have.
See it in practice
The worked example on the homepage walks through Atorvastatin + Coenzyme Q10 in the same shape used across the database: what is happening, the mechanism, the recommendation, and the primary literature.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.