Cordyceps
Adaptogen ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Energy-boosting medicinal mushroom traditionally used in Tibetan and Chinese medicine. Enhances oxygen utilization, ATP production, and physical performance.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Cordyceps is an adaptogen most often used for athletic performance, energy and stamina, oxygen utilization. NutriStack rates the overall evidence as emerging. A typical adult dose is 1,000–3,000 mg daily, commonly taken as cordyceps militaris fruiting body extract (standardized for cordycepin). This profile indexes 21 sources.
The bottom line
Evidence rating emerging. Most-documented uses: athletic performance, energy and stamina, oxygen utilization. 21 sources indexed (2010–2025), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Cordycepin (3'-deoxyadenosine) activates AMPK (signals low energy status, promotes catabolic pathways); net effect on ATP in humans is unclear. Shown to increase EPO under hypoxic conditions in vitro only; no human RCT confirms serum EPO increase. Adenosine receptor agonist providing anti-inflammatory effects.16,17
Dosing & protocol.
Take in the morning or pre-workout; may be too stimulating for evening6,13
What it actually costs.
Real-world pricing across three quality tiers. Assumes Cordyceps Militaris Extract.
Assumes 1,000-3,000 mg/day. Vendor basis: iHerb, Vitacost, Amazon marketplace, and specialty mushroom brands; cordycepin-standardized extracts are premium. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Cordyceps is consumed more like a medicinal mushroom than a standard food; extract potency can differ from dried mushroom.
Full safety detail.
Side effects
- GI upset
- Insomnia if taken late
- Dry mouth
Contraindications
- Autoimmune conditions
- Blood thinners
- Upcoming surgery
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
10- 1Efficacy of traditional Chinese medicine Cordyceps sinensis as an adjunctive treatment in patients with renal dysfunction: a systematic-review and meta-analysisSource linkedPMIDWu F, Xu C, Si X et al. · Frontiers in Medicine · 2025
- 2Adjuvant treatment with Cordyceps sinensis for lung cancer: A systematic review and meta-analysis of randomized controlled trials.PMIDWang C, Wang J, Qi Y · Journal of Ethnopharmacology · 2024
Meta-analysis of 12 RCTs (928 patients) showed CS as adjuvant for lung cancer improved tumor response rate (RR: 1.17), immune function (CD4, CD8, NK cells), quality of life (KPS MD: 8.20), and reduced adverse drug reactions including myelosuppression, leukopenia, and radiation pneumonitis.
- 3Therapeutic efficacy and pharmacological mechanism of Bailing capsule on chronic obstructive pulmonary disease: a meta-analysis and network pharmacology.PMIDMa G, Jin Y · Pharmaceutical Biology · 2024
Meta-analysis of 27 RCTs showed Bailing capsule (derived from Cordyceps sinensis) significantly improved FEV1, FEV1/FVC ratio, 6-min walk test, reduced acute COPD exacerbations, and improved quality of life.
- 4Fermented Ophiocordyceps sinensis mycelium products for preventing contrast-associated acute kidney injury: a systematic review of randomized controlled trialsPMIDPu F, Li T, Shen C et al. · Renal failure · 2024
Pu F, Li T, Shen C et al.. Fermented Ophiocordyceps sinensis mycelium products for preventing contrast-associated acute kidney injury: a systematic review of randomized controlled trials. Renal failure. 2024
- 5Effects and safety of Ophiocordyceps sinensis preparation in the adjuvant treatment for dialysis patients: a systematic review and meta-analysisPMIDLiu M, Cui C, Chang T et al. · Frontiers in pharmacology · 2024
Liu M, Cui C, Chang T et al.. Effects and safety of Ophiocordyceps sinensis preparation in the adjuvant treatment for dialysis patients: a systematic review and meta-analysis. Frontiers in pharmacology. 2024
- 6Effectiveness of Cordyceps sinensis as an adjunct to physical performance: A systematic review and meta-analysis.PMIDHirsch KR, Smith-Ryan AE, Roelofs EJ et al. · Journal of Dietary Supplements · 2023
Systematic review found limited but suggestive evidence that Cordyceps supplementation may improve VO2 max and exercise performance, though more high-quality RCTs are needed.
- 7The effects of Ophiocordyceps sinensis combined with ACEI/ARB on diabetic kidney disease: A systematic review and meta-analysisPMIDYan G, Chang T, Zhao Y et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2023
Yan G, Chang T, Zhao Y et al.. The effects of Ophiocordyceps sinensis combined with ACEI/ARB on diabetic kidney disease: A systematic review and meta-analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023
- 8Effects and safety of Ophiocordyceps sinensis preparation in the adjuvant treatment for dialysis patients: A protocol for systematic review and meta-analysisPMIDLiu M, Chang T, Zou D et al. · Medicine · 2022
Liu M, Chang T, Zou D et al.. Effects and safety of Ophiocordyceps sinensis preparation in the adjuvant treatment for dialysis patients: A protocol for systematic review and meta-analysis. Medicine. 2022
- 9Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysisSource linkedPMIDOng BY, Aziz Z et al. · Journal of Traditional Chinese Medicine · 2020
- 10Effectiveness and Safety of Oral Cordyceps sinensis on Stable COPD of GOLD Stages 2-3: Systematic Review and Meta-AnalysisPMIDYu X, Mao Y, Shergis JL et al. · Evidence-based complementary and alternative medicine : eCAM · 2019
Yu X, Mao Y, Shergis JL et al.. Effectiveness and Safety of Oral Cordyceps sinensis on Stable COPD of GOLD Stages 2-3: Systematic Review and Meta-Analysis. Evidence-based complementary and alternative medicine : eCAM. 2019
Randomized controlled trials
4- 11A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adultsPMIDJung SJ et al. · J Funct Foods · 2024
NK cell activity markedly increased within 4 weeks in males; IL-1beta reduced in males and IL-6 decreased in females
- 12Effects of Concurrent Training and a Multi-Ingredient Performance Supplement Containing Rhodiola rosea and Cordyceps sinensis on Body Composition, Performance, and Health in Active MenSource linkedPMIDKreipke VC, Moffatt RJ, Tanner CJ et al. · Journal of Dietary Supplements · 2021
- 13Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic SupplementationPMIDHirsch KR et al. · J Diet Suppl · 2017
After 3 weeks of supplementation VO2max improved by 4.8 ml/kg/min; time to exhaustion increased by 69.8 seconds
- 14Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trialPMIDChen S et al. · J Altern Complement Med · 2010
After 12 weeks of Cs-4, the metabolic threshold increased by 10.5% vs no change in placebo group
Reviews & position papers
5- 15Toxicological safety evaluation of the cultivated Chinese cordycepsPMIDLi X et al. · J Ethnopharmacol · 2021
Acute toxicity LD50 >5 g/kg (non-toxic); no abnormal changes in tissues or organs at 20 g/kg; no-observed-adverse-effect level >1000 mg/kg
- 16Beneficial Effect of Cordyceps militaris on Exercise Performance via Promoting Cellular Energy ProductionPMIDXiao H et al. · Evid Based Complement Alternat Med · 2020
Cordyceps militaris improves exercise performance associated with increased ATP production rather than decreased muscle fatigue
- 17Anti-inflammatory effects of cordycepin: A reviewPMIDTan L et al. · Phytother Res · 2020
Cordycepin exerts anti-inflammatory effects against ALI, asthma, rheumatoid arthritis, Parkinson's disease, hepatitis, and atherosclerosis
- 18Anti-fatigue activities of polysaccharides from Cordyceps militaris: a systematic reviewXu YF · Evid Based Complement Alternat Med · 2016
- 19Pharmacological and therapeutic potential of Cordyceps with special reference to CordycepinSource linkedPMIDTuli HS, Sandhu SS, Sharma AK · 3 Biotech · 2014
Reference material
2- 20Chen B, Sun Y, Luo F et al.. Bioactive Metabolites and Potential Mycotoxins Produced by Cordyceps Fungi: A Review of Safety. Toxins. 2020Source linkedPMID
- 21Liu Y, Guo ZJ, Zhou XW. Chinese Cordyceps: Bioactive Components, Antitumor Effects and Underlying Mechanism-A Review. Molecules (Basel, Switzerland). 2022Source linkedPMID
Common questions.
Quick answers about Cordyceps, drawn from the data on this page.
What is Cordyceps?
Energy-boosting medicinal mushroom traditionally used in Tibetan and Chinese medicine. Enhances oxygen utilization, ATP production, and physical performance.
What is Cordyceps used for?
Commonly cited benefits of Cordyceps include: Athletic performance; Energy and stamina; Oxygen utilization; Immune modulation. NutriStack rates the overall evidence as emerging.
What is a typical dose of Cordyceps?
A typical adult dose of Cordyceps is 1,000–3,000 mg daily. The commonly recommended form is Cordyceps militaris fruiting body extract (standardized for cordycepin). These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Cordyceps?
Reported side effects include gi upset, insomnia if taken late, dry mouth. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Cordyceps?
NutriStack rates this as Emerging, meaning early RCT signal, mechanistic data, or limited human evidence. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
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