Herb ·Emerging evidence ·Reviewed May 2026
Polyphenol from red wine and grapes studied for metabolic, vascular, and oxidative-stress markers. Best taken with a fat source for absorption.
The bottom line
Evidence rating emerging. Most-documented uses: healthy-aging research, cardiometabolic markers, oxidative-stress support. 20 sources indexed (2014–2025), with 15 interaction records on file.
Core mechanism
Influences SIRT1, AMPK, Nrf2, NF-kB, and mitochondrial pathways in preclinical or mechanistic research; human clinical outcome evidence is mixed and should not be framed as proven longevity benefit.15
Take with fat-containing meal; highly bioavailable but rapidly metabolized3,5
Ranked by evidence and value.
Real-world pricing across three quality tiers. Assumes Trans-Resveratrol.
Assumes 150-300 mg/day from goal dosage. Vendor basis: NOW/iHerb, Vitacost, Life Extension, and Amazon marketplace; micronized or high-purity trans-resveratrol costs more. Updated 2026-05-28.
How much you'd eat to match a supplemental dose.
Supplemental longevity-style doses are much higher than dietary intake.
Food provides small amounts, not supplement-scale amounts.
Dose: 150-300 mg daily15
Timing: With food containing some fat
Use trans-resveratrol rather than mixed or unspecified isomers.
Dose: 150-500 mg daily9
Timing: Morning with food
Usually used as a long-game supplement, not for acute effects.
Dose: 150-250 mg daily18
Timing: Earlier in the day
Avoid assuming more is automatically better.
What to test, the optimal window inside the conventional range, and how long a response takes.
Resveratrol (150 to 1000 mg per day) modestly lowers hsCRP and fasting insulin in meta-analyses; clinical effect size is small and bioavailability is poor.9,1
Resveratrol has poor oral bioavailability (about 1 percent). Trans-resveratrol forms and micronized preparations have better PK.
Resveratrol may modestly lower fasting insulin, but the effect is small, dose-dependent, and inconsistent given its poor oral bioavailability, and it is clearest in people who start with insulin resistance or impaired glucose metabolism.7,9
Requires an 8 to 12 hour overnight fast; draw at the same morning time on repeat tests. Recent carbohydrate intake, acute illness, and weight change strongly affect results, so retest after at least 8 to 12 weeks of consistent use.
Where this appears in the symptom-to-supplement map, ranked by relevance.
Sirtuin activator with mixed but predominantly modest effects on metabolic markers in humans.15,3
Bioavailability is poor; piperine or micronized forms preferred.
Resveratrol upregulates endothelial nitric oxide synthase and has acutely improved flow-mediated dilation in some studies.8,12
Bioavailability is low and longer-term human vascular data remain limited.
Resveratrol is used for antioxidant and anti-inflammatory support, though human outcome data are mixed.3,20
Supportive rather than foundational.
Evidence-based stacks that include it, with the exact dose and timing each one uses.
Polyphenol studied for metabolic and oxidative-stress markers; pathway findings should not be treated as proven cardiovascular outcome benefits.20,2
Resveratrol is a polyphenol that has been proposed to engage SIRT1 signaling, although direct sirtuin activation is debated and may be substrate dependent. Human longevity evidence remains limited and mixed, so it is included as a speculative adjunct.1,2
NMN supports NAD+-pathway markers, while resveratrol has sirtuin-related preclinical research; direct human evidence for the combination is absent.
Recommendation: Present as an exploratory pairing only. Do not claim proven longevity, healthspan, DNA-repair, or clinical outcome benefits from the combination.
Quercetin inhibits resveratrol glucuronidation, increasing resveratrol bioavailability. Both are polyphenol antioxidants with complementary targets.
Recommendation: Take together. Quercetin may increase resveratrol bioavailability by inhibiting sulfotransferases and glucuronidases that metabolize resveratrol.
Resveratrol is lipophilic and absorbs better with dietary fat. Both have anti-inflammatory and cardioprotective properties.
Recommendation: Take resveratrol with fish oil or a fat-containing meal for improved bioavailability.
Resveratrol is lipophilic and absorbs better with dietary fat. Both have anti-inflammatory and cardioprotective properties.
Recommendation: Take resveratrol with fish oil triple strength or a fat-containing meal for improved bioavailability.
Resveratrol is lipophilic and absorbs better with dietary fat. Both have anti-inflammatory and cardioprotective properties.
Recommendation: Take resveratrol with krill oil or a fat-containing meal for improved bioavailability.
MCT Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Resveratrol.
Recommendation: Take Resveratrol with MCT Oil or another fat-containing meal to improve absorption.
Flaxseed Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Resveratrol.
Recommendation: Take Resveratrol with Flaxseed Oil or another fat-containing meal to improve absorption.
Evening Primrose Oil provides a fat-containing carrier that can improve absorption of fat-soluble compounds like Resveratrol.
Recommendation: Take Resveratrol with Evening Primrose Oil or another fat-containing meal to improve absorption.
Both polyphenols have antiplatelet activity, so combining them may additively reduce platelet aggregation and increase bleeding tendency.
Recommendation: Generally safe together at supplemental doses, but use caution if you take anticoagulant or antiplatelet drugs, and stop both about 1 to 2 weeks before surgery.
Resveratrol inhibits CYP2C9, the main enzyme that clears the more potent S-enantiomer of warfarin, and also inhibits BCRP-mediated efflux. In animal models this raises plasma warfarin AUC and significantly increases INR. Resveratrol additionally inhibits platelet COX-1 and thromboxane A2, adding a pharmacodynamic bleeding risk. Combined effects can amplify warfarin's anticoagulation.
Recommendation: Avoid resveratrol supplements (typically 100-500 mg/day) while on warfarin. If you choose to take it, keep the dose constant and ask your anticoagulation clinic to recheck INR within 1-2 weeks of starting or stopping.
Resveratrol inhibits CYP3A4 in vitro and in animal pharmacokinetic studies, where it has raised plasma exposure of CYP3A4 substrates such as nicardipine and ticagrelor. Layered on top of fluconazole's CYP3A4 and CYP2C9 inhibition, this could blunt clearance of other prescription medications metabolized by these enzymes.
Recommendation: Pause resveratrol supplementation during your fluconazole course, particularly if you also take statins, calcium channel blockers, anticoagulants, or benzodiazepines. Resume once fluconazole has cleared.
High-dose resveratrol (≥150 mg/day) modestly reduces systolic blood pressure and improves endothelial function. Combined with metoprolol, the net effect is generally beneficial for vascular health, though additive blood-pressure lowering is possible at higher doses.
Recommendation: Resveratrol at typical supplement doses (100-500 mg/day) is generally compatible with metoprolol. Monitor blood pressure when adding higher doses (≥150 mg/day) and tell your prescriber if readings drop below target.
Numbered references. Citations throughout the page link here.
Azargoonjahromi A, Abutalebian F, Hoseinpour F. The role of resveratrol in neurogenesis: a systematic review. Nutrition reviews. 2025
Amini A, Heidari-Soureshjani S, Sherwin CM et al.. The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review. Cardiovascular & hematological disorders drug targets. 2025
Resveratrol supplementation significantly reduced inflammatory markers including CRP and TNF-alpha in patients with coronary artery disease in this meta-analysis and meta-regression.
Larik MO, Ahmed A, Khan L et al.. Effects of resveratrol on polycystic ovarian syndrome: a systematic review and meta-analysis of randomized controlled trials. Endocrine. 2024
Yadegar S, Mohammadi F, Yadegar A et al.. Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review. Phytotherapy research : PTR. 2024
Huang Q, An Z, Xin X et al.. The Effectiveness of Curcumin, Resveratrol, and Silymarin on MASLD: A Systematic Review and Meta-Analysis. Food science & nutrition. 2024
Resveratrol supplementation significantly improved insulin resistance, total testosterone, and other metabolic parameters in women with polycystic ovary syndrome compared to placebo.
Resveratrol supplementation significantly improved endothelial function, which could be beneficial for patients with cardiovascular diseases.
Meta-analysis of 17 RCTs (871 T2DM patients) showed resveratrol superior to placebo on fasting blood glucose and total cholesterol at doses >=500mg, improved HbA1c at 3 months.
Resveratrol supplementation significantly reduced systolic blood pressure in type 2 diabetic patients, with beneficial effects on markers of renal function observed in pooled analysis of RCTs.
Higher-dose resveratrol (>=150 mg/day) significantly reduces systolic blood pressure, though no significant effects on diastolic blood pressure were observed.
Resveratrol supplementation significantly improved endothelial function and reduced systolic blood pressure in patients with metabolic syndrome and related disorders based on pooled RCT data.
Review describes SIRT1-related mechanisms; this should not be presented as proven human longevity or clinical outcome benefit.
No conclusive clinical evidence currently exists to advocate resveratrol recommendation in any healthcare setting; optimal dosage, long-term effects, and drug interactions still need well-designed RCTs.
Resveratrol well tolerated at doses up to 5 g/day; mild-to-moderate GI adverse effects at >=0.5 g/day for long periods; effects reversible. Blood-thinning and estrogenic effects at high doses noted.
This page is educational. Do not start, stop, or change a supplement or medication based on it without checking with a qualified healthcare professional.
Use this with your stack
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
NutriStack