Cocaine
Other ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Cocaine is not supported by NutriStack. Safety information only.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This safety record covers a controlled, investigational, or otherwise out-of-scope substance. It remains available for reference, but it is not part of NutriStack's public supplement publication set.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Cocaine is an other. NutriStack rates the overall evidence as insufficient. This profile indexes 15 sources.
The bottom line
Evidence rating insufficient. 15 sources indexed (1991–2025), with 0 interaction records on file.
Dosing & protocol.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Not recommended / controlled substance.
No effective supplement dose exists. Cost is intentionally not modeled for this illegal non-medical substance. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Cocaine is a controlled stimulant drug, not a nutrient or diet-replaceable supplement.
Full safety detail.
Side effects
- Hypertension
- Tachycardia
- Arrhythmias
- Chest pain and myocardial infarction
- Stroke
- Anxiety or paranoia
- Seizures
- Strong craving and dependence
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
10- 1Cocaine Cues Used in Experimental Research: A Systematic ReviewPMIDBrobbin E, Lowry N, Cella M et al. · Brain sciences · 2025
Brobbin E, Lowry N, Cella M et al.. Cocaine Cues Used in Experimental Research: A Systematic Review. Brain sciences. 2025
- 2Methylphenidate for the Treatment of Cocaine Use Disorder: A Systematic Review and Meta-analysisPMIDBiso L, Lebosi M, Bonaso M et al. · Journal of addiction medicine · 2025
Biso L, Lebosi M, Bonaso M et al.. Methylphenidate for the Treatment of Cocaine Use Disorder: A Systematic Review and Meta-analysis. Journal of addiction medicine. 2025
- 3Critical appraisal and systematic review of genes linked with cocaine addiction, depression and anxietyPMIDKaushik S, Ahmad F, Choudhary S et al. · Neuroscience and biobehavioral reviews · 2023
Kaushik S, Ahmad F, Choudhary S et al.. Critical appraisal and systematic review of genes linked with cocaine addiction, depression and anxiety. Neuroscience and biobehavioral reviews. 2023
- 4The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) in Cancer: A Systematic ReviewPMIDOwe-Larsson M, Pawłasek J, Piecha T et al. · International journal of molecular sciences · 2023
Owe-Larsson M, Pawłasek J, Piecha T et al.. The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) in Cancer: A Systematic Review. International journal of molecular sciences. 2023
- 5Transcranial Magnetic Stimulation for the Treatment of Cocaine Addiction: A Systematic ReviewPMIDTorres-Castaño A, Rivero-Santana A, Perestelo-Pérez L et al. · Journal of clinical medicine · 2021
Torres-Castaño A, Rivero-Santana A, Perestelo-Pérez L et al.. Transcranial Magnetic Stimulation for the Treatment of Cocaine Addiction: A Systematic Review. Journal of clinical medicine. 2021
- 6Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysisPMIDArenas DJ, Beltran S, Zhou S et al. · Scientific reports · 2020
Arenas DJ, Beltran S, Zhou S et al.. Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis. Scientific reports. 2020
- 7Outcomes of beta blocker use in cocaine-associated chest pain: a meta-analysisPMIDPham D, Addison D, Kayani W et al. · Emergency medicine journal : EMJ · 2018
Pham D, Addison D, Kayani W et al.. Outcomes of beta blocker use in cocaine-associated chest pain: a meta-analysis. Emergency medicine journal : EMJ. 2018
- 8N-acetylcysteine for treating cocaine addiction - A systematic reviewPMIDNocito Echevarria MA, Andrade Reis T, Ruffo Capatti G et al. · Psychiatry research · 2017
Nocito Echevarria MA, Andrade Reis T, Ruffo Capatti G et al.. N-acetylcysteine for treating cocaine addiction - A systematic review. Psychiatry research. 2017
- 9Modafinil Treatment of Cocaine Dependence: A Systematic Review and Meta-AnalysisPMIDSangroula D, Motiwala F, Wagle B et al. · Substance use & misuse · 2017
Sangroula D, Motiwala F, Wagle B et al.. Modafinil Treatment of Cocaine Dependence: A Systematic Review and Meta-Analysis. Substance use & misuse. 2017
- 10Meta-analysis of desipramine as an adjunct in the treatment of cocaine addictionPMIDLevin FR, Lehman AF · Journal of clinical psychopharmacology · 1991
Levin FR, Lehman AF. Meta-analysis of desipramine as an adjunct in the treatment of cocaine addiction. Journal of clinical psychopharmacology. 1991
Randomized controlled trials
2- 11A cholecystokinin B receptor antagonist and cocaine interaction, phase I studyPMIDElkashef A, Brašić JR, Cantelina LR Jr et al. · CNS neuroscience & therapeutics · 2019
Elkashef A, Brašić JR, Cantelina LR Jr et al.. A cholecystokinin B receptor antagonist and cocaine interaction, phase I study. CNS neuroscience & therapeutics. 2019
- 12Cocaine stimulates the human cardiovascular system via a central mechanism of action.PMIDVongpatanasin W et al. · Circulation · 1999
Human study showed intranasal cocaine markedly increased sympathetic nerve activity, blood pressure, and heart rate via a central mechanism.
Reviews & position papers
3- 13Acute and Chronic Effects of Cocaine on Cardiovascular Health.PMIDKim ST, Park T · Int J Mol Sci · 2019
Review summarizes links to hypertension, arrhythmia, myocardial infarction, and coronary disease, especially in people with higher baseline cardiac risk.
- 14Adverse effects of levamisole in cocaine users: a review and risk assessmentPMIDBrunt TM, van den Berg J, Pennings E et al. · Archives of toxicology · 2017
Brunt TM, van den Berg J, Pennings E et al.. Adverse effects of levamisole in cocaine users: a review and risk assessment. Archives of toxicology. 2017
- 15Chronic cocaine disrupts mesocortical learning mechanisms.PMIDBuchta WC, Riegel AC · Brain Res · 2015
Review argues chronic cocaine hijacks reward-related dopamine plasticity and contributes to persistent addiction pathology.
Common questions.
Quick answers about Cocaine, drawn from the data on this page.
What is Cocaine?
Cocaine is not supported by NutriStack. Safety information only.
What are the side effects of Cocaine?
Reported side effects include hypertension, tachycardia, arrhythmias, chest pain and myocardial infarction, stroke, anxiety or paranoia. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Cocaine?
NutriStack rates this as Insufficient, meaning the body of evidence reviewed in NutriStack's tiering framework. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Cocaine in NutriStack.
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.