ModerateCaution
Melatonin
Both target sleep and may increase next-day grogginess or obscure adverse effects.
Recommendation: Avoid combining until individual response is known; do not drive if sedated.
DSIP (Delta Sleep-Inducing Peptide)
Peptide ·Insufficient evidence ·Reviewed May 2026
DSIP is a nonapeptide historically investigated for sleep regulation and stress physiology. It is not FDA-approved, and controlled human insomnia studies are small and inconsistent. It should not be used as a substitute for evidence-based insomnia evaluation, sleep apnea diagnosis, or approved sleep therapies.
The bottom line
Evidence rating insufficient. Most-documented uses: small studies in chronic insomnia, stress and sleep architecture research interest, no approved sleep indication. 3 sources indexed (1987–1999), with 3 interaction records on file.
The science
How it works, mechanistically.
Core mechanism
DSIP biology remains incompletely resolved, with proposed effects on sleep architecture, stress-axis regulation, endogenous opioids, and mitochondrial or neuroendocrine signaling. Human sleep trials found mixed objective and subjective results, so the mechanism cannot be translated into reliable clinical benefit.3,1
Class
Investigational sleep-modulating nonapeptide
Found in food
None as a dietary supplement
Low-status signs
No recognized dietary deficiency state exists for this peptide
Dosing
Dosing & protocol.
Common range
No FDA-approved human dose; older studies used protocol-specific injections
Recommended form
Not recommended outside approved research
Peptides are generally not reliably orally bioavailable unless a specific studied oral formulation is used. Human use of research-grade products is not appropriate.
Forms
Forms & what to buy.
Ranked by evidence and value.
Research Injectable DSIP Recommended
Older studies used parenteral protocols; human self-use is not established. Injection adds sterility and dosing risks.
Intranasal or Sublingual Marketed DSIP
Reliable absorption and efficacy are not established. Variable delivery and product quality.
Cost
What it actually costs.
Real-world pricing across three quality tiers. Assumes Research Injectable DSIP.
BudgetBest value
$60 /mo
$2.00 per dose
Mid
$180 /mo
$6.00 per dose
Premium
$450 /mo
$15.00 per dose
Research-market pricing is not a dosing recommendation; human use is not FDA-approved unless specifically stated. Updated 2026-06-04.
Goals
Goal-based dosing.
Chronic Insomnia Research
Dose: Protocol-specific only1,2
Timing: Study protocol only
Human trials are small and mixed.
Sleep Optimization
Timing: Not applicable
Evaluate behavioral, circadian, medication, and sleep-apnea causes.
Stress Recovery
Dose: No approved dose
Timing: Not applicable
Stress claims are not clinically established.
Why people use it
Symptoms it's matched to.
Where this appears in the symptom-to-supplement map, ranked by relevance.
Insomnia
12% relevance
Older insomnia studies are small and inconsistent.2,1
SleepInsufficient evidenceAvoid outside research
Use CBT-I and evaluate sleep disorders.
Nonrestorative sleep
8% relevance
Sleep architecture claims are not reliably proven.1,2
SleepInsufficient evidenceAvoid
Screen for sleep apnea and circadian disruption.
Stress-related sleep disruption
7% relevance
Stress-axis claims remain mechanistic and unproven clinically.1,2
StressInsufficient evidenceAvoid
Behavioral and medical sleep care has stronger evidence.
Safety
Full safety detail.
Side effects
- Drowsiness
- Vivid dreams
- Headache
- Dizziness
- Next-day grogginess
- Injection-site reaction
- Unknown long-term neuroendocrine effects
Interactions
Interaction records.
InfoCaution
L-Theanine
L-theanine may add relaxation or sedation and confound sleep tracking.
Recommendation: Change one sleep intervention at a time.
ModerateCaution
5-HTP
5-HTP can cause sleepiness and serotonergic adverse effects; combining with unapproved DSIP complicates safety monitoring.
Recommendation: Avoid multi-agent sleep stacks without clinician review.
Search all 3 interaction records for DSIP (Delta Sleep-Inducing Peptide) →
Sources
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Randomized controlled trials
2- 1Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind studyNeeds sourceNo linkSchneider-Helmert D et al. · Neuropsychobiology · 1992
Most measures did not change
- 2Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacsNeeds sourceNo linkSchneider-Helmert D et al. · International Journal of Clinical Pharmacology Research · 1987
Small short-term study
Reviews & position papers
1- 3Delta sleep-inducing peptide: a still unresolved riddleNeeds sourceNo linkGraf MV et al. · Journal of Sleep Research · 1999
Mechanism remains unresolved
Keep exploring
Deep dives & adjacent profiles.
This page is educational. Do not start, stop, or change a supplement or medication based on it without checking with a qualified healthcare professional.
Use this with your stack
DSIP (Delta Sleep-Inducing Peptide) in NutriStack.
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.