Omega-7
Omega/Fatty Acid ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Uncommon omega fatty acid supporting mucous membrane health and metabolic function.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Omega-7 is an omega/fatty acid most often used for mucous membrane health, skin hydration, metabolic support. NutriStack rates the overall evidence as emerging. A typical adult dose is 210-420 mg daily, commonly taken as purified palmitoleic acid (provinal) or sea buckthorn oil. This profile indexes 16 sources.
The bottom line
Evidence rating emerging. Most-documented uses: mucous membrane health, skin hydration, metabolic support. 16 sources indexed (2011–2025), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Palmitoleic acid acts as a lipokine signaling molecule between adipose tissue and other organs. It is studied for mucous membrane hydration and metabolic markers, but CRP reduction has not been consistently shown.14,1
Dosing & protocol.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Purified Palmitoleic Acid / Sea Buckthorn.
Assumes 210-420 mg/day. Vendor basis: Life Extension, iHerb, Vitacost, and Amazon marketplace; Provinal-style purified omega-7 sets premium pricing. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Omega-7 content varies strongly by food; sea buckthorn oil is the most concentrated common source.
Full safety detail.
Side effects
- GI upset
- Fishy burps (fish-derived)
Contraindications
- Blood thinners (mild)
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Randomized controlled trials
10- 1Effects of a palmitoleic acid concentrated oil on C-reactive protein levels in adults: A randomized, double-blind placebo-controlled clinical trialPMIDBridges MD, Vennam SS, Davis T et al. · The American journal of clinical nutrition · 2025
Bridges MD, Vennam SS, Davis T et al.. Effects of a palmitoleic acid concentrated oil on C-reactive protein levels in adults: A randomized, double-blind placebo-controlled clinical trial. The American journal of clinical nutrition. 2025
- 2Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled studyPMIDLee E et al. · Heliyon · 2023
In 90 participants, 500 mg/day palmitoleic acid for 12 weeks significantly improved skin hydration and transepidermal water loss vs placebo.
- 3Treatment of Resistant Acne Vulgaris in Adolescents Using Dietary Supplementation with Magnesium, Phosphate and Fatty Acids (Omega 6 and 7): Comparison with 13-Cis-Retinoic AcidPMIDde Souza Pereira R · J Diet Suppl · 2023
Single-blind randomized study of 532 patients found dietary supplementation with omega-6, omega-7, magnesium, and phosphate achieved 100% complete symptom regression vs 68% for isotretinoin in acne vulgaris treatment over 6 months.
- 4Macadamia nut effects on cardiometabolic risk factors: a randomised trialPMIDJones JL, Sabate J, Heskey C, Oda K, Miles F, Rajaram S · J Nutr Sci · 2023
Randomized crossover trial in 35 overweight/obese adults found daily macadamia nut consumption (~15% calories) did not increase weight or body fat and showed non-significant reductions in total cholesterol (-2.1%) and LDL-C (-4%).
- 5Protocol for a randomized placebo-controlled clinical trial using pure palmitoleic acid to ameliorate insulin resistance and lipogenesis in overweight and obese subjects with prediabetesPMIDCetin E, Pedersen B, Porter LM et al. · Frontiers in endocrinology · 2023
Cetin E, Pedersen B, Porter LM et al.. Protocol for a randomized placebo-controlled clinical trial using pure palmitoleic acid to ameliorate insulin resistance and lipogenesis in overweight and obese subjects with prediabetes. Frontiers in endocrinology. 2023
- 6Omega-7 Mixed Fatty Acid Supplementation Fails to Reduce Serum Inflammatory Biomarkers: A Placebo-Controlled, Double-Blind Randomized Crossover TrialPMIDRotan KR et al. · Nutrients · 2021
Three weeks of 688 mg/day palmitoleate did not produce a statistically detectable change in inflammatory biomarkers compared to MCT placebo, questioning claims about CRP reduction.
- 7Supplementation with Seabuckthorn Oil Augmented in 16:1n-7t Increases Serum Trans-Palmitoleic Acid in Metabolically Healthy Adults: A Randomized Crossover Dose-Escalation StudyPMIDHuang NK, Matthan NR, Galluccio JM et al. · The Journal of nutrition · 2020
Huang NK, Matthan NR, Galluccio JM et al.. Supplementation with Seabuckthorn Oil Augmented in 16:1n-7t Increases Serum Trans-Palmitoleic Acid in Metabolically Healthy Adults: A Randomized Crossover Dose-Escalation Study. The Journal of nutrition. 2020
- 8Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: a randomized, double-blind, placebo-controlled studyPMIDLarmo PS et al. · Maturitas · 2014
In 116 postmenopausal women, 3g daily sea buckthorn oil for 3 months showed significantly better improvement in vaginal epithelium integrity vs placebo (OR=3.1, 95% CI 1.11-8.95).
- 9WITHDRWAN: Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: a double-blinded, randomized, placebo controlled studyPMIDBernstein AM, Roizen MF, Martinez L · Journal of clinical lipidology · 2014
Bernstein AM, Roizen MF, Martinez L. WITHDRWAN: Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: a double-blinded, randomized, placebo controlled study. Journal of clinical lipidology. 2014
- 10Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: a double-blind, randomized, placebo controlled studySource linkedPMIDBernstein AM, Rozen MF, Sondike SB · J Clin Lipidol · 2014
Reviews & position papers
3- 11Effect of Cis-palmitoleic acid supplementation on inflammation and expression of HNF4γ, HNF4α and IL6 in patients with ulcerative colitisPMIDBueno-Hernández N, Sixtos-Alonso MS, Milke García MDP et al. · Minerva gastroenterologica e dietologica · 2017
Bueno-Hernández N, Sixtos-Alonso MS, Milke García MDP et al.. Effect of Cis-palmitoleic acid supplementation on inflammation and expression of HNF4γ, HNF4α and IL6 in patients with ulcerative colitis. Minerva gastroenterologica e dietologica. 2017
- 12Effects of step-wise increases in dietary carbohydrate on circulating saturated Fatty acids and palmitoleic Acid in adults with metabolic syndromePMIDVolk BM, Kunces LJ, Freidenreich DJ et al. · PloS one · 2014
Volk BM, Kunces LJ, Freidenreich DJ et al.. Effects of step-wise increases in dietary carbohydrate on circulating saturated Fatty acids and palmitoleic Acid in adults with metabolic syndrome. PloS one. 2014
- 13Effects of oral sea buckthorn oil on tear film Fatty acids in individuals with dry eyePMIDJärvinen RL, Larmo PS, Setälä NL et al. · Cornea · 2011
Järvinen RL, Larmo PS, Setälä NL et al.. Effects of oral sea buckthorn oil on tear film Fatty acids in individuals with dry eye. Cornea. 2011
Mechanistic & preclinical
2- 14Palmitoleic Acid Ameliorates Metabolic Disorders and Inflammation by Modulating Gut Microbiota and Serum MetabolitesPMIDZhang Y et al. · J Agric Food Chem · 2024
Palmitoleic acid ameliorated metabolic disorders and inflammation by modulating gut microbiota composition and serum metabolites in a preclinical model.
- 15Dietary Palmitoleic Acid Attenuates Atherosclerosis Progression and Hyperlipidemia in Low-Density Lipoprotein Receptor-Deficient MicePMIDSouza CO et al. · Mol Nutr Food Res · 2019
Dietary palmitoleic acid attenuated atherosclerosis progression and reduced hyperlipidemia in LDLR-deficient mice, supporting potential metabolic benefits.
Common questions.
Quick answers about Omega-7, drawn from the data on this page.
What is Omega-7?
Uncommon omega fatty acid supporting mucous membrane health and metabolic function.
What is Omega-7 used for?
Commonly cited benefits of Omega-7 include: Mucous membrane health; Skin hydration; Metabolic support; Vaginal dryness. NutriStack rates the overall evidence as emerging.
What is a typical dose of Omega-7?
A typical adult dose of Omega-7 is 210-420 mg daily. The commonly recommended form is Purified palmitoleic acid (Provinal) or sea buckthorn oil. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Omega-7?
Reported side effects include gi upset, fishy burps (fish-derived). This is educational information; check with a healthcare professional before use.
How strong is the evidence for Omega-7?
NutriStack rates this as Emerging, meaning early RCT signal, mechanistic data, or limited human evidence. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Omega-7 in NutriStack.
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