Other ·Insufficient evidence ·Reviewed May 2026
Psilocybin is not supported by NutriStack. Safety information only.
The bottom line
Evidence rating insufficient. 15 sources indexed (2013–2025), with 5 interaction records on file.
Ranked by evidence and value.
Real-world pricing across three quality tiers. Assumes Not recommended / controlled substance.
No effective supplement dose exists. Cost is intentionally not modeled for this illegal non-medical substance. Updated 2026-05-28.
How much you'd eat to match a supplemental dose.
Psilocybin is a psychoactive compound, not a nutrient or diet-replaceable supplement.
What to test, the optimal window inside the conventional range, and how long a response takes.
Single dose of 25 mg psilocybin produces detectable urinary psilocin for 8 to 24 hours; serum psilocin half-life is about 3 hours.13,1
Specialty toxicology lab only. Therapeutic context (clinical trials in depression, end-of-life distress) does not require lab confirmation but tracks subjective and clinical scales (MADRS, QIDS).
Combining psilocybin with lithium has been associated in case reports and online experience reports with seizures and severe adverse neurological reactions, making this one of the most dangerous documented psychedelic combinations.
Recommendation: Do not combine. If you take any lithium-containing product, do not use psilocybin and seek medical advice.
St. John's Wort has serotonergic and weak monoamine-oxidase-modulating activity, so combining it with the serotonergic psychedelic psilocybin raises the theoretical risk of excessive serotonergic effects and unpredictable response.
Recommendation: Do not combine without medical guidance. Anyone using St. John's Wort should seek medical advice before considering psilocybin.
5-HTP increases serotonin synthesis and, combined with the serotonergic psychedelic psilocybin, raises the theoretical risk of excessive serotonergic stimulation.
Recommendation: Do not combine. Seek medical advice before using either agent if the other is in use.
Sertraline blocks the serotonin transporter and occupies postsynaptic 5-HT2A receptors over time, blunting psilocybin's intended psychedelic effect. Most psilocybin therapy trials require patients to be off SSRIs for several weeks before dosing. The combined serotonergic load also carries a theoretical risk of serotonin syndrome, though documented cases with classical psychedelics are rare.
Recommendation: Do not take psilocybin while on sertraline if you want a meaningful experience — the response will likely be blunted. If you have stopped sertraline, follow clinical-trial protocols and wait at least 2 weeks before psilocybin.
Fluoxetine substantially blunts psilocybin's psychedelic effects through chronic 5-HT2A receptor downregulation, and its very long half-life means the effect persists for weeks after stopping. There is also a theoretical risk of serotonin syndrome with combined serotonergic load.
Recommendation: Do not take psilocybin while on fluoxetine. Because fluoxetine and norfluoxetine have half-lives of 1-2 weeks and 1-2+ weeks respectively, wait at least 5 weeks after the last fluoxetine dose before any psilocybin exposure.
Numbered references. Citations throughout the page link here.
Swieczkowski D, Kwaśny A, Pruc M et al.. Efficacy and safety of psilocybin in the treatment of Major Depressive Disorder (MDD): A dose-response network meta-analysis of randomized placebo-controlled clinical trials. Psychiatry research. 2025
Menon V, Ramamurthy P, Venu S et al.. Randomized Controlled Trials of Psilocybin-Assisted Therapy in the Treatment of Major Depressive Disorder: Systematic Review and Meta-Analysis. Acta psychiatrica Scandinavica. 2025
Meshkat S, Malik G, Zeifman RJ et al.. Efficacy and safety of psilocybin for the treatment of substance use disorders: A systematic review. Neuroscience and biobehavioral reviews. 2025
Borgogna NC, Owen T, Petrovitch D et al.. Incremental efficacy systematic review and meta-analysis of psilocybin-for-depression RCTs. Psychopharmacology. 2025
Yerubandi A, Thomas JE, Bhuiya NMMA et al.. Acute Adverse Effects of Therapeutic Doses of Psilocybin: A Systematic Review and Meta-Analysis. JAMA network open. 2024
Hsu TW, Tsai CK, Kao YC et al.. Comparative oral monotherapy of psilocybin, lysergic acid diethylamide, 3,4-methylenedioxymethamphetamine, ayahuasca, and escitalopram for depressive symptoms: systematic review and Bayesian network meta-analysis. BMJ (Clinical research ed.). 2024
van der Meer PB, Fuentes JJ, Kaptein AA et al.. Therapeutic effect of psilocybin in addiction: A systematic review. Frontiers in psychiatry. 2023
Dawood Hristova JJ, Pérez-Jover V. Psychotherapy with Psilocybin for Depression: Systematic Review. Behavioral sciences (Basel, Switzerland). 2023
Perez N, Langlest F, Mallet L et al.. Psilocybin-assisted therapy for depression: A systematic review and dose-response meta-analysis of human studies. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2023
Haikazian S, Chen-Li DCJ, Johnson DE et al.. Psilocybin-assisted therapy for depression: A systematic review and meta-analysis. Psychiatry research. 2023
van Amsterdam J, van den Brink W. The therapeutic potential of psilocybin: a systematic review. Expert opinion on drug safety. 2022
Goel DB, Zilate S. Potential Therapeutic Effects of Psilocybin: A Systematic Review. Cureus. 2022
Phase 2 trial found a 25 mg supervised dose reduced depression scores more than control over 3 weeks, but headache, nausea, dizziness, and suicidality-related events were observed across groups.
Human study found that blocking 5-HT2A receptors attenuated psilocybin-related changes in visual processing and hallucination-like effects.
Review concluded psilocybin has limited reinforcing effects but can still lead to dangerous behavior and worsening of mental illness in unprepared or unsupervised users.
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