CJC-1295
Other ·Insufficient evidence ·Reviewed May 2026
Synthetic long-acting GHRH analog studied in healthy adults for GH/IGF-1 stimulation. It is not an FDA-approved wellness therapy, and FDA flags serious adverse events and limited clinical data.
- Unknown product purity, potency, and sterility risk outside regulated drug supply
- Injection-site reactions or infection risk with injectable products
- Immune reactions are possible with peptide impurities or aggregation
- Pregnancy or nursing
- History of cancer or active malignancy unless specifically cleared by an oncologist
The bottom line
Evidence rating insufficient. Most-documented uses: no approved wellness use, human efficacy evidence is insufficient for consumer guidance, reference-only safety profile. 3 sources indexed (2006–2026), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Acts as a GHRH receptor agonist and can raise growth hormone and IGF-1. This endocrine activation creates clinically meaningful safety uncertainty outside supervised research.1,2
Dosing & protocol.
Route-specific guidance is intentionally not provided for unapproved research peptides.
Full safety detail.
Side effects
- Unknown product purity, potency, and sterility risk outside regulated drug supply
- Injection-site reactions or infection risk with injectable products
- Immune reactions are possible with peptide impurities or aggregation
Contraindications
- Pregnancy or nursing
- History of cancer or active malignancy unless specifically cleared by an oncologist
- Use by competitive athletes subject to anti-doping rules
- Use without clinician supervision
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Randomized controlled trials
2- 1Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsSource linkedPMIDTeichman SL et al. · J Clin Endocrinol Metab · 2006
CJC-1295 produced prolonged GH and IGF-1 stimulation in healthy adults, supporting pharmacologic activity but not wellness use.
- 2Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogSource linkedPMIDIonescu M, Frohman LA · J Clin Endocrinol Metab · 2006
Small human endocrine study; not evidence of long-term safety or clinical benefit for consumer use.
Reference material
1- 3Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety RisksSource linkedURLU.S. Food and Drug Administration · FDA · 2026
FDA identifies immunogenicity/impurity concerns, limited clinical data, and serious adverse events including increased heart rate and systemic vasodilatory reaction.
Deep dives & adjacent profiles.
This page is educational. Do not start, stop, or change a supplement or medication based on it without checking with a qualified healthcare professional.
Use this with your stack
CJC-1295 in NutriStack.
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.