Selank
Peptide ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Selank is a synthetic heptapeptide derived from tuftsin and developed in Russia for anxiety-related conditions. It is not FDA-approved in the United States, and most clinical evidence is small, Russian-language, or not independently replicated. It should not replace established anxiety treatment, psychotherapy, or prescribed psychiatric medications.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This safety record covers a controlled, investigational, or otherwise out-of-scope substance. It remains available for reference, but it is not part of NutriStack's public supplement publication set.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Selank is a peptide most often used for anxiolytic research interest, possible gabaergic modulation, stress and cognition research. NutriStack rates the overall evidence as insufficient. A typical adult dose is No FDA-approved human dose in the US; Russian product use is not a supplement standard, commonly taken as not recommended outside regulated clinical context. This profile indexes 3 sources.
The bottom line
Evidence rating insufficient. Most-documented uses: anxiolytic research interest, possible gabaergic modulation, stress and cognition research. 3 sources indexed (2015–2018), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Selank appears to modulate GABAergic and monoaminergic signaling, enkephalin metabolism, neurotrophic signaling, and stress-response pathways in experimental models. Reported anxiolytic effects may occur without classic benzodiazepine sedation, but human evidence remains limited. Intranasal research products have uncertain dose, purity, and sterility.3,1
Dosing & protocol.
Peptides are generally not reliably orally bioavailable unless a specific studied oral formulation is used. Human use of research-grade products is not appropriate.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Laboratory Research Reagent.
Research-market pricing is not a dosing recommendation; human use is not FDA-approved unless specifically stated. Updated 2026-06-04.
Full safety detail.
Side effects
- Nasal irritation
- Headache
- Drowsiness or activation
- Mood changes
- Allergic reaction
- Uncertain product quality
Contraindications
- Severe depression or suicidality without psychiatric care
- Pregnancy and breastfeeding
- Use with sedatives or psychiatric medications without clinician review
- Bipolar disorder or mania history without specialist care1
- Research-grade intranasal products
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Randomized controlled trials
1- 1Optimization of the treatment of anxiety disorders with selankMedvedev VE et al. · Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova · 2015
Selank plus phenazepam was studied
Reviews & position papers
1- 2Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological ActivityKolomin T et al. · Current Protein and Peptide Science · 2018
GABA-related and gene-expression effects reviewed
Mechanistic & preclinical
1- 3GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 CellsKolomin T et al. · Frontiers in Pharmacology · 2017
Selank affected GABAergic gene expression
Common questions.
Quick answers about Selank, drawn from the data on this page.
What is Selank?
Selank is a synthetic heptapeptide derived from tuftsin and developed in Russia for anxiety-related conditions. It is not FDA-approved in the United States, and most clinical evidence is small, Russian-language, or not independently replicated. It should not replace established anxiety treatment, psychotherapy, or prescribed psychiatric medications.
What is Selank used for?
Commonly cited benefits of Selank include: Anxiolytic research interest; Possible GABAergic modulation; Stress and cognition research; No FDA-approved US indication. NutriStack rates the overall evidence as insufficient.
What is a typical dose of Selank?
A typical adult dose of Selank is No FDA-approved human dose in the US; Russian product use is not a supplement standard. The commonly recommended form is Not recommended outside regulated clinical context. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Selank?
Reported side effects include nasal irritation, headache, drowsiness or activation, mood changes, allergic reaction, uncertain product quality. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Selank?
NutriStack rates this as Insufficient, meaning the body of evidence reviewed in NutriStack's tiering framework. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Selank in NutriStack.
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.