Fisetin
Antioxidant ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Fisetin is a plant flavonol found in strawberries, apples, and onions that is studied for healthy-aging, antioxidant, and anti-inflammatory effects. It is one of the most-studied dietary senolytic candidates, but the strongest data come from aged-mouse studies and cell models; human clinical outcome evidence is still preliminary and ongoing.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Fisetin is an antioxidant most often used for healthy-aging research interest, antioxidant support, anti-inflammatory. NutriStack rates the overall evidence as emerging. A typical adult dose is 100-500 mg daily (research protocols often use intermittent high-dose schedules), commonly taken as liposomal or phytosome fisetin for improved absorption; otherwise taken with a fat-containing meal. This profile indexes 4 sources.
- Generally well tolerated in short studies
- GI upset at high doses
- Limited long-term human safety data
- Pregnancy and breastfeeding (insufficient safety data)
- Anticoagulant or antiplatelet therapy (theoretical bleeding risk, flavonoid CYP modulation)
The bottom line
Evidence rating emerging. Most-documented uses: healthy-aging research interest, antioxidant support, anti-inflammatory. 4 sources indexed (2001–2019), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Fisetin acts as an antioxidant flavonol and modulates inflammatory and stress-response signaling, including NF-kB, Nrf2, and mTOR/sirtuin-related pathways in preclinical research. It is best known as a candidate senolytic that may help clear senescent cells and reduce senescence-associated secretory phenotype (SASP) markers in animal and in vitro models, but these mechanisms have not been confirmed as clinical benefits in humans. Oral bioavailability is low and the compound is rapidly conjugated and cleared.2,4
Dosing & protocol.
Poorly water-soluble with low oral bioavailability and rapid metabolism; take with dietary fat or use a liposomal/phytosome formulation. Many research protocols use short intermittent high-dose courses rather than daily low dosing.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Standard Fisetin (98% powder/capsule).
Assumes roughly 100-200 mg/day. Plain 98% fisetin powder is the value leader; liposomal and phytosome formulations command most premium pricing. Intermittent high-dose research protocols change effective monthly cost. Updated 2026-06-03.
Full safety detail.
Side effects
- Generally well tolerated in short studies
- GI upset at high doses
- Limited long-term human safety data
Contraindications
- Pregnancy and breastfeeding (insufficient safety data)
- Anticoagulant or antiplatelet therapy (theoretical bleeding risk, flavonoid CYP modulation)
- Drugs metabolized by CYP enzymes (theoretical interaction at high doses)
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Reviews & position papers
2- 1Cellular senescence: Defining a path forwardPMIDGorgoulis V et al. · Cell · 2019
Frames senescent-cell accumulation as a driver of age-related dysfunction and senolytics (including flavonoids like fisetin and quercetin) as an emerging but unproven therapeutic approach in humans.
- 2Therapeutic potential of dietary flavonoid fisetin: A comprehensive reviewPMIDKhan N et al. · Antioxid Redox Signal · 2013
Reviews fisetin's antioxidant, anti-inflammatory, and anticancer activity in preclinical models and highlights low oral bioavailability and rapid metabolism as key translational barriers.
Mechanistic & preclinical
2- 3Fisetin is a senotherapeutic that extends health and lifespanPMIDYousefzadeh MJ et al. · EBioMedicine · 2018
Intermittent oral fisetin reduced senescent-cell burden and senescence markers in multiple tissues and extended median and maximum lifespan when given to aged mice; human benefit was not tested.
- 4The flavonoid fisetin promotes nerve cell survival from oxidative stress by enhancing intracellular glutathionePMIDIshige K, Schubert D, Sagara Y · Free Radic Biol Med · 2001
Fisetin protected neuronal cells from oxidative stress in vitro, in part by raising intracellular glutathione, supporting an antioxidant mechanism that has not yet been confirmed clinically.
Common questions.
Quick answers about Fisetin, drawn from the data on this page.
What is Fisetin?
Fisetin is a plant flavonol found in strawberries, apples, and onions that is studied for healthy-aging, antioxidant, and anti-inflammatory effects. It is one of the most-studied dietary senolytic candidates, but the strongest data come from aged-mouse studies and cell models; human clinical outcome evidence is still preliminary and ongoing.
What is Fisetin used for?
Commonly cited benefits of Fisetin include: Healthy-aging research interest; Antioxidant support; Anti-inflammatory; Cellular senescence research. NutriStack rates the overall evidence as emerging.
What is a typical dose of Fisetin?
A typical adult dose of Fisetin is 100-500 mg daily (research protocols often use intermittent high-dose schedules). The commonly recommended form is Liposomal or phytosome fisetin for improved absorption; otherwise taken with a fat-containing meal. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Fisetin?
Reported side effects include generally well tolerated in short studies, gi upset at high doses, limited long-term human safety data. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Fisetin?
NutriStack rates this as Emerging, meaning early RCT signal, mechanistic data, or limited human evidence. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Fisetin in NutriStack.
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.