Magnesium Malate
Mineral ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Magnesium combined with malic acid, targeted for energy and fibromyalgia support.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Magnesium Malate is a mineral most often used for energy production, fibromyalgia support, muscle pain. NutriStack rates the overall evidence as moderate. A typical adult dose is 200-350 mg elemental magnesium daily, commonly taken as magnesium malate capsules or powder. This profile indexes 12 sources.
The bottom line
Evidence rating moderate. Most-documented uses: energy production, fibromyalgia support, muscle pain. 12 sources indexed (1992–2025), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Malic acid is a Krebs cycle intermediate that supports ATP production. Magnesium is a cofactor for >300 enzymes including those in energy metabolism.6,7
Dosing & protocol.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Magnesium Malate.
Assumes 200-350 mg elemental magnesium/day. Vendor basis: NOW/iHerb, Vitacost, Amazon marketplace, and practitioner brands; capsules usually cost more than powder. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Foods provide elemental magnesium, not magnesium malate specifically.
Full safety detail.
Side effects
- Well tolerated
- Mild laxative effect
Contraindications
- Kidney disease
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
4- 1Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsPMIDArgeros Z, Xu X, Bhandari B et al. · Hypertension (Dallas, Tex. : 1979) · 2025
Argeros Z, Xu X, Bhandari B et al.. Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Hypertension (Dallas, Tex. : 1979). 2025
- 2Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trialsPMIDMoabedi M, Aliakbari M, Erfanian S et al. · Frontiers in psychiatry · 2023
Moabedi M, Aliakbari M, Erfanian S et al.. Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials. Frontiers in psychiatry. 2023
- 3The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trialsPMIDAskari M, Mozaffari H, Jafari A et al. · Critical reviews in food science and nutrition · 2021
Askari M, Mozaffari H, Jafari A et al.. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition. 2021
- 4Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled TrialsPMIDVeronese N, Dominguez LJ, Pizzol D et al. · Nutrients · 2021
Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2021
Randomized controlled trials
3- 5Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical TrialPMIDAndretta A et al. · Nutrients · 2022
Pain severity diminished significantly (p=0.029) with magnesium supplementation in fibromyalgia patients in a 1-month RCT.
- 6Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot studyPMIDRussell IJ et al. · J Rheumatol · 1995
Super Malic (malic acid + magnesium) showed positive trends for pain reduction in fibromyalgia in a randomized double-blind crossover pilot study of 24 patients.
- 7Management of fibromyalgia: rationale for the use of magnesium and malic acidAbraham GE, Flechas JD · J Nutr Med · 1992
Reviews & position papers
4- 8Magnesium and Fibromyalgia: A Literature ReviewPMIDBoulis M, Boulis M, Clauw DJ · J Prim Care Community Health · 2021
Seven systematic reviews identified supporting magnesium supplementation for fibromyalgia; serum magnesium levels were significantly lower in fibromyalgia patients with meaningful association between magnesium and fatigue.
- 9Bioavailability of magnesium food supplements: A systematic reviewPMIDAtes M et al. · Nutrition · 2021
Organic magnesium formulations (including malate) appear to be more bioavailable than inorganic compounds, though percentage of absorption is dose dependent.
- 10Magnesium in Prevention and TherapyPMIDGrober U, Schmidt J, Kisters K · Nutrients · 2015
Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including energy production, protein synthesis, and muscle and nerve function.
- 11Magnesium: its proven and potential clinical significanceSource linkedPMIDGuerrera MP, Volpe SL, Mao JJ · Am Fam Physician · 2009
Common questions.
Quick answers about Magnesium Malate, drawn from the data on this page.
What is Magnesium Malate?
Magnesium combined with malic acid, targeted for energy and fibromyalgia support.
What is Magnesium Malate used for?
Commonly cited benefits of Magnesium Malate include: Energy production; Fibromyalgia support; Muscle pain. NutriStack rates the overall evidence as moderate.
What is a typical dose of Magnesium Malate?
A typical adult dose of Magnesium Malate is 200-350 mg elemental magnesium daily. The commonly recommended form is Magnesium malate capsules or powder. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Magnesium Malate?
Reported side effects include well tolerated, mild laxative effect. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Magnesium Malate?
NutriStack rates this as Moderate, meaning several aligned RCTs or one large RCT plus supporting reviews. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Deep dives & adjacent profiles.
This page is educational. Do not start, stop, or change a supplement or medication based on it without checking with a qualified healthcare professional.
Use this with your stack
Magnesium Malate in NutriStack.
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.