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Hyaluronic Acid

Other ·Exploratory record · not publication-reviewed ·Updated September 28, 2026

Key molecule for skin hydration, joint lubrication, and tissue repair.

Evidence tier
Moderate
Indexed sources
16 2012–2025
Interactions
0
Cost / month
$4.50 budget
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Hyaluronic Acid is an other most often used for skin hydration, joint lubrication, wound healing. NutriStack rates the overall evidence as moderate. A typical adult dose is 120-240 mg daily, commonly taken as low molecular weight ha (better absorption) or high mw for joints. This profile indexes 16 sources.

What it's good for
  • Skin hydration1,9
  • Joint lubrication11,12
  • Wound healing
  • Eye health
What to watch for
  • Well tolerated
  • Rare allergic reactions
  • Cancer history (theoretical growth factor concern)

The bottom line

Evidence rating moderate. Most-documented uses: skin hydration, joint lubrication, wound healing. 16 sources indexed (2012–2025), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Retains up to 1,000x its weight in water, providing tissue hydration. In joints, provides viscosity to synovial fluid. In skin, maintains turgor and supports wound healing.9,1

Class
Glycosaminoglycan
Found in food
Bone broth, Soy products, Root vegetables
Low-status signs
Not essential, made endogenously
Absorption
Water-soluble; take with food
Dosing

Dosing & protocol.

Common range
120-240 mg daily
Recommended form
Low molecular weight HA (better absorption) or high MW for joints

Take with food and plenty of water1,3

Cost

What it actually costs.

Real-world pricing across three quality tiers. Assumes Low Molecular Weight HA.

BudgetBest value
$4.50 /mo
$0.15 per dose
Mid
$10.50 /mo
$0.35 per dose
Premium
$21.00 /mo
$0.70 per dose

Assumes 120-240 mg/day. Vendor basis: NOW/iHerb, Vitacost, Life Extension, and Amazon marketplace; joint formulas with collagen or UC-II cost more. Updated 2026-05-28.

From food

The same dose, as food.

How much you'd eat to match a supplemental dose.

120-240 mg hyaluronic acid
Bone broth, chicken skin, cartilage-rich cuts, organ meats, soy foods, and root vegetables may support related substrates but do not provide reliable hyaluronic acid dosing.

Food comparisons are indirect; supplements usually use purified hyaluronic acid.

Safety

Full safety detail.

Side effects

  • Well tolerated
  • Rare allergic reactions

Contraindications

  • Cancer history (theoretical growth factor concern)
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

8

Randomized controlled trials

3

Reviews & position papers

3

Reference material

2
FAQ

Common questions.

Quick answers about Hyaluronic Acid, drawn from the data on this page.

What is Hyaluronic Acid?

Key molecule for skin hydration, joint lubrication, and tissue repair.

What is Hyaluronic Acid used for?

Commonly cited benefits of Hyaluronic Acid include: Skin hydration; Joint lubrication; Wound healing; Eye health. NutriStack rates the overall evidence as moderate.

What is a typical dose of Hyaluronic Acid?

A typical adult dose of Hyaluronic Acid is 120-240 mg daily. The commonly recommended form is Low molecular weight HA (better absorption) or high MW for joints. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Hyaluronic Acid?

Reported side effects include well tolerated, rare allergic reactions. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Hyaluronic Acid?

NutriStack rates this as Moderate, meaning several aligned RCTs or one large RCT plus supporting reviews. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Hyaluronic Acid in NutriStack.

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