Ketamine
Other ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Ketamine is not supported by NutriStack. Safety information only.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This safety record covers a controlled, investigational, or otherwise out-of-scope substance. It remains available for reference, but it is not part of NutriStack's public supplement publication set.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Ketamine is an other. NutriStack rates the overall evidence as insufficient. This profile indexes 15 sources.
The bottom line
Evidence rating insufficient. 15 sources indexed (2007–2026), with 0 interaction records on file.
Dosing & protocol.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Controlled medical-only substance.
No effective supplement dose exists. Cost is intentionally not modeled for this controlled medical-only substance. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Ketamine is a prescription anesthetic and dissociative drug, not a nutrient or food-derived supplement.
Full safety detail.
Side effects
- Dissociation and impaired judgment
- Nausea and vomiting
- Hypertension and tachycardia
- Falls or trauma
- Tolerance and psychological dependence
- Ulcerative cystitis and lower urinary tract injury
- Abdominal pain and possible liver abnormalities with chronic heavy use
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
12- 1Ketamine and Esketamine for Late-Life Depression: A Systematic Review of Efficacy, Safety, and TolerabilityPMIDSukhdeo R, Tamura JK, Dri CE et al. · The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
Sukhdeo R, Tamura JK, Dri CE et al.. Ketamine and Esketamine for Late-Life Depression: A Systematic Review of Efficacy, Safety, and Tolerability. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2026
- 2Safety and efficacy of ketamine for the treatment of patients with alcohol use disorder: a systematic reviewPMIDRathore BS, Singh S, Gupta M et al. · The American journal of drug and alcohol abuse · 2025
Rathore BS, Singh S, Gupta M et al.. Safety and efficacy of ketamine for the treatment of patients with alcohol use disorder: a systematic review. The American journal of drug and alcohol abuse. 2025
- 3Oral Ketamine as an Analgesic Therapy: Systematic Review of Randomised Clinical TrialsPMIDUmbacia MA, Calsina-Berna A, Hernández-Rico AN et al. · Journal of pain & palliative care pharmacotherapy · 2025
Umbacia MA, Calsina-Berna A, Hernández-Rico AN et al.. Oral Ketamine as an Analgesic Therapy: Systematic Review of Randomised Clinical Trials. Journal of pain & palliative care pharmacotherapy. 2025
- 4The efficacy and safety of ketamine in the treatment of super-refractory status epilepticus: a systematic reviewPMIDYan M, Sun T, Liu J et al. · Journal of neurology · 2024
Yan M, Sun T, Liu J et al.. The efficacy and safety of ketamine in the treatment of super-refractory status epilepticus: a systematic review. Journal of neurology. 2024
- 5Ketamine and electroconvulsive therapy for severe depression: A network meta-analysis of efficacy and safetyPMIDLiu Y, Yang J, Liu Y · Journal of psychiatric research · 2024
Liu Y, Yang J, Liu Y. Ketamine and electroconvulsive therapy for severe depression: A network meta-analysis of efficacy and safety. Journal of psychiatric research. 2024
- 6Ketamine versus electroconvulsive therapy for major depressive episode: An updated systematic review and non-inferiority meta-analysisPMIDPetrucci ABC, Fernandes JVA, Reis IA et al. · Psychiatry research · 2024
Petrucci ABC, Fernandes JVA, Reis IA et al.. Ketamine versus electroconvulsive therapy for major depressive episode: An updated systematic review and non-inferiority meta-analysis. Psychiatry research. 2024
- 7Ketamine treatment for anhedonia in unipolar and bipolar depression: a systematic reviewPMIDKwaśny A, Kwaśna J, Wilkowska A et al. · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
Kwaśny A, Kwaśna J, Wilkowska A et al.. Ketamine treatment for anhedonia in unipolar and bipolar depression: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2024
- 8Ketamine for the Treatment of Psychiatric Disorders: A Systematic Review and Meta-AnalysisPMIDKwan ATH, Lakhani M, Singh G et al. · CNS spectrums · 2024
Kwan ATH, Lakhani M, Singh G et al.. Ketamine for the Treatment of Psychiatric Disorders: A Systematic Review and Meta-Analysis. CNS spectrums. 2024
- 9Maintenance ketamine treatment for depression: a systematic review of efficacy, safety, and tolerabilityPMIDSmith-Apeldoorn SY, Veraart JK, Spijker J et al. · The lancet. Psychiatry · 2022
Smith-Apeldoorn SY, Veraart JK, Spijker J et al.. Maintenance ketamine treatment for depression: a systematic review of efficacy, safety, and tolerability. The lancet. Psychiatry. 2022
- 10Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysisPMIDRhee TG, Shim SR, Forester BP et al. · JAMA psychiatry · 2022
Rhee TG, Shim SR, Forester BP et al.. Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysis. JAMA psychiatry. 2022
- 11Effectiveness and Safety of Ketamine for Unipolar Depression: a Systematic ReviewPMIDMemon RI, Naveed S, Faquih AE et al. · The Psychiatric quarterly · 2020
Memon RI, Naveed S, Faquih AE et al.. Effectiveness and Safety of Ketamine for Unipolar Depression: a Systematic Review. The Psychiatric quarterly. 2020
- 12Ketamine Infusions for Chronic Pain: A Systematic Review and Meta-analysis of Randomized Controlled TrialsPMIDOrhurhu V, Orhurhu MS, Bhatia A et al. · Anesthesia and analgesia · 2019
Orhurhu V, Orhurhu MS, Bhatia A et al.. Ketamine Infusions for Chronic Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Anesthesia and analgesia. 2019
Reviews & position papers
2- 13The abuse liability of ketamine: A scoping review of preclinical and clinical studies.PMIDLe TT et al. · J Psychiatr Res · 2022
Scoping review found well-established abuse liability for racemic ketamine, with limited controlled-setting clinical data showing less misuse than seen in recreational contexts.
- 14The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use.PMIDKalsi SS et al. · Emerg Health Threats J · 2011
Review describes agitation, hallucinations, psychosis, hypertension, tachycardia, dependence, abdominal pain, liver abnormalities, and urologic injury in recreational users.
Observational studies
1- 15Ketamine-associated ulcerative cystitis: a new clinical entity.PMIDShahani R et al. · Urology · 2007
Case series of daily ketamine users documented severe lower urinary tract symptoms and inflammatory bladder injury consistent with ketamine-associated cystitis.
Common questions.
Quick answers about Ketamine, drawn from the data on this page.
What is Ketamine?
Ketamine is not supported by NutriStack. Safety information only.
What are the side effects of Ketamine?
Reported side effects include dissociation and impaired judgment, nausea and vomiting, hypertension and tachycardia, falls or trauma, tolerance and psychological dependence, ulcerative cystitis and lower urinary tract injury. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Ketamine?
NutriStack rates this as Insufficient, meaning the body of evidence reviewed in NutriStack's tiering framework. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Ketamine in NutriStack.
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.