Garlic Extract
Herb ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Aged garlic extract supports cardiovascular health and immune function.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Garlic Extract is a herb most often used for cardiovascular health, blood pressure, cholesterol. NutriStack rates the overall evidence as strong. A typical adult dose is 600-1,200 mg daily (aged garlic extract), commonly taken as aged garlic extract (kyolic is well-studied). This profile indexes 19 sources.
The bottom line
Evidence rating strong. Most-documented uses: cardiovascular health, blood pressure, cholesterol. 19 sources indexed (1999–2025), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Allicin and S-allyl cysteine inhibit HMG-CoA reductase (mild), reduce platelet aggregation, lower blood pressure via H2S and NO pathways, and provide antioxidant/antimicrobial effects.15,16
Dosing & protocol.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Aged Garlic Extract.
Assumes 600-1,200 mg/day. Vendor basis: Kyolic/iHerb, Vitacost, Life Extension, and Amazon marketplace; aged garlic costs more than basic odorless garlic. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Aged garlic extract is standardized differently from fresh garlic; odor compounds and allicin potential vary by preparation.
Full safety detail.
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
12- 1The Effect of Aged Garlic Supplementation on Blood Pressure and Lipid Profile: A Dose-Response Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled TrialsPMIDHaghighatdoost F et al. · Phytotherapy Research · 2025
Aged garlic significantly reduced systolic BP by 2.49 mmHg and LDL cholesterol by 4.41 mg/dL across 19 randomized controlled trials.
- 2Garlic Extract in Rheumatological Diseases: A Systematic ReviewPMIDFreire de Carvalho J, Lerner A, Benzvi C · Complementary medicine research · 2025
Freire de Carvalho J, Lerner A, Benzvi C. Garlic Extract in Rheumatological Diseases: A Systematic Review. Complementary medicine research. 2025
- 3Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trialsPMIDSaadh MJ, Kariem M, Shukla M et al. · Prostaglandins & Other Lipid Mediators · 2024
Aged garlic extract supplementation significantly reduced both systolic and diastolic blood pressure in hypertensive patients compared to placebo across pooled RCTs.
- 4Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysisPMIDGadidala SK, Johny E, Thomas C et al. · Phytotherapy Research · 2023
Garlic extract supplementation significantly improved lipid markers (reducing total cholesterol and LDL) and inflammatory markers in patients with coronary artery disease.
- 5Effects of garlic supplementation on components of metabolic syndrome: a systematic review, meta-analysis, and meta-regression of randomized controlled trialsPMIDFu Z, Lv J, Gao X et al. · BMC complementary medicine and therapies · 2023
Fu Z, Lv J, Gao X et al.. Effects of garlic supplementation on components of metabolic syndrome: a systematic review, meta-analysis, and meta-regression of randomized controlled trials. BMC complementary medicine and therapies. 2023
- 6Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trialsPMIDXiaohui L, Jinqi L, Xiaofang X et al. · African health sciences · 2023
Xiaohui L, Jinqi L, Xiaofang X et al.. Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials. African health sciences. 2023
- 7A systematic review of randomized controlled trials related to the effects of garlic supplementation on platelet aggregationPMIDMollahosseini M, Hosseini-Marnani E, Panjeshahin A et al. · Phytotherapy research : PTR · 2022
Mollahosseini M, Hosseini-Marnani E, Panjeshahin A et al.. A systematic review of randomized controlled trials related to the effects of garlic supplementation on platelet aggregation. Phytotherapy research : PTR. 2022
- 8Effects of garlic supplementation on serum inflammatory markers: A systematic review and meta-analysis of randomized controlled trialsPMIDMirzavandi F, Mollahosseini M, Salehi-Abargouei A et al. · Diabetes & Metabolic Syndrome · 2020
Garlic supplementation significantly reduced serum CRP, TNF-alpha, and IL-6 levels across randomized controlled trials, indicating broad anti-inflammatory effects.
- 9Effects of garlic supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trialsPMIDPanjeshahin A, Mollahosseini M, Panbehkar-Jouybari M et al. · Phytotherapy research : PTR · 2020
Panjeshahin A, Mollahosseini M, Panbehkar-Jouybari M et al.. Effects of garlic supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy research : PTR. 2020
- 10Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and ReviewPMIDRied K · Journal of Nutrition · 2016
Garlic supplements lowered systolic BP by 8.3 mmHg and diastolic BP by 5.5 mmHg in hypertensives, similarly to standard anti-hypertensive medications.
- 11Garlic supplementation and lipid levels: a systematic review and meta-analysisSource linkedPMIDRied K, Toben C, Fakler P · Nutr Rev · 2013
- 12Effect of garlic on blood pressure: a systematic review and meta-analysisSource linkedPMIDRied K, Frank OR, Stocks NP et al. · BMC Cardiovasc Disord · 2008
Randomized controlled trials
2- 13The Effect of Kyolic Aged Garlic Extract on Gut Microbiota, Inflammation, and Cardiovascular Markers in Hypertensives: The GarGIC TrialPMIDRied K et al. · Frontiers in Nutrition · 2018
Kyolic aged garlic extract effectively reduced central blood pressure, pulse pressure, and arterial stiffness while improving gut microbiota in hypertensive patients.
- 14Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trialPMIDRied K et al. · Maturitas · 2010
Aged garlic extract is superior to placebo in lowering systolic blood pressure similarly to first-line medications in patients with treated but uncontrolled hypertension.
Reviews & position papers
3- 15The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfidePMIDChung LY · Journal of Medicinal Food · 2006
S-allyl cysteine, the most abundant bioactive in aged garlic extract, has potent antioxidant, anti-inflammatory, cardioprotective, and neuroprotective properties.
- 16Aged garlic extract and its bioactive compounds inhibit platelet aggregationSource linkedPMIDRahman K, Billington D · J Nutr · 2000
- 17Antimicrobial properties of allicin from garlicPMIDAnkri S et al. · Microbes and Infection · 1999
Allicin demonstrates broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, antifungal, antiparasitic, and antiviral properties via thiol-reactive mechanisms.
Reference material
2- 18Serrano JCE, Castro-Boqué E, García-Carrasco A et al.. Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial. Nutrients. 2023Source linkedPMID
- 19Rauf A, Abu-Izneid T, Thiruvengadam M et al.. Garlic (Allium sativum L.): Its Chemistry, Nutritional Composition, Toxicity, and Anticancer Properties. Current topics in medicinal chemistry. 2022Source linkedPMID
Common questions.
Quick answers about Garlic Extract, drawn from the data on this page.
What is Garlic Extract?
Aged garlic extract supports cardiovascular health and immune function.
What is Garlic Extract used for?
Commonly cited benefits of Garlic Extract include: Cardiovascular health; Blood pressure; Cholesterol; Immune support. NutriStack rates the overall evidence as strong.
What is a typical dose of Garlic Extract?
A typical adult dose of Garlic Extract is 600-1,200 mg daily (aged garlic extract). The commonly recommended form is Aged garlic extract (Kyolic is well-studied). These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Garlic Extract?
Reported side effects include bad breath, gi upset, increased bleeding risk. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Garlic Extract?
NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Garlic Extract in NutriStack.
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