Potassium
Mineral ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Crucial electrolyte for heart rhythm, muscle contraction, nerve signaling, and blood pressure regulation. Most people don't get enough from diet alone.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Potassium is a mineral most often used for blood pressure regulation, heart rhythm, muscle function. NutriStack rates the overall evidence as strong. A typical adult dose is 99–500 mg supplemental (2,600 mg women / 3,400 mg men total daily need per 2019 NASEM, mostly from food), commonly taken as potassium citrate or gluconate. This profile indexes 19 sources.
The bottom line
Evidence rating strong. Most-documented uses: blood pressure regulation, heart rhythm, muscle function. 19 sources indexed (1997–2025), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Primary intracellular cation maintaining cell membrane potential via Na+/K+-ATPase pump. Essential for cardiac myocyte depolarization/repolarization, skeletal muscle contraction, nerve impulse conduction, and renal sodium excretion (lowering blood pressure).16
Dosing & protocol.
Supplements limited to 99mg per capsule by FDA; get most from food4,9
What it actually costs.
Real-world pricing across three quality tiers. Assumes Potassium Citrate / Gluconate.
Assumes a low-dose OTC daily serving, not prescription-strength potassium replacement. Per-tablet pricing understates the cost of clinically meaningful repletion when larger doses are needed. Updated 2026-04-02.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Food should provide most daily potassium because supplements are intentionally low-dose.
This is near the adult male daily target and shows why food matters most.
Full safety detail.
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
17- 1Comparative Efficacy and Safety of Potassium-Competitive Acid Blocker-Based Dual, Triple, and Quadruple Regimens for First-Line Helicobacter pylori Infection Treatment: A Systematic Review and Network Meta-AnalysisPMIDRokkas T, Ekmektzoglou K, Niv Y et al. · The American journal of gastroenterology · 2025
Rokkas T, Ekmektzoglou K, Niv Y et al.. Comparative Efficacy and Safety of Potassium-Competitive Acid Blocker-Based Dual, Triple, and Quadruple Regimens for First-Line Helicobacter pylori Infection Treatment: A Systematic Review and Network Meta-Analysis. The American journal of gastroenterology. 2025
- 2Novel Potassium Binders in Reduction of Hyperkalemia and Optimization of RAAS Inhibitors Treatment in Patients with Chronic Kidney Disease or Heart Failure: A Systematic Review and Meta-analysisPMIDHuang N, Xu Y, Liu C et al. · Drugs · 2025
Huang N, Xu Y, Liu C et al.. Novel Potassium Binders in Reduction of Hyperkalemia and Optimization of RAAS Inhibitors Treatment in Patients with Chronic Kidney Disease or Heart Failure: A Systematic Review and Meta-analysis. Drugs. 2025
- 3Effect of changes in potassium intake on blood pressure: a dose-response meta-analysis of randomized clinical trials (2000-2024)Source linkedPMIDFilippini T, Malavolti M, Cilloni S et al. · Clin Kidney J · 2025
- 4Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment LengthPMIDBehers BJ, Behers BM, Stephenson-Moe CA et al. · Nutrients · 2024
Potassium at dosages ≤60 mmol/day reduced SBP by -2.34 mmHg, and durations >1 month reduced SBP by -2.80 mmHg in the general normotensive population. Greater reductions occurred at lower dosages and longer treatment durations.
- 5Comparative Efficacy and Safety of Potassium-Competitive Acid Blockers and Proton Pump Inhibitors for First-Line Helicobacter pylori Eradication Therapy: A Systematic Review and Network Meta-AnalysisPMIDOuyang M, Zou S, Cheng Q et al. · Helicobacter · 2024
Ouyang M, Zou S, Cheng Q et al.. Comparative Efficacy and Safety of Potassium-Competitive Acid Blockers and Proton Pump Inhibitors for First-Line Helicobacter pylori Eradication Therapy: A Systematic Review and Network Meta-Analysis. Helicobacter. 2024
- 6Treatment of Helicobacter pylori with potassium competitive acid blockers: A systematic review and meta-analysisPMIDKanu JE, Soldera J · World journal of gastroenterology · 2024
Kanu JE, Soldera J. Treatment of Helicobacter pylori with potassium competitive acid blockers: A systematic review and meta-analysis. World journal of gastroenterology. 2024
- 7Effect of Potassium Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis of Intervention StudiesPMIDD'Elia L, Cappuccio FP, Masulli M et al. · Nutrients · 2023
In 5 studies with 332 participants, potassium supplementation was associated with significant increase in FMD (MD 0.74%), with higher effect for urinary potassium excretion >90 mmol/day. This supports increasing dietary potassium to reduce cardiovascular risk.
- 8Global mean potassium intake: a systematic review and Bayesian meta-analysisPMIDReddin C, Ferguson J, Murphy R et al. · European journal of nutrition · 2023
Reddin C, Ferguson J, Murphy R et al.. Global mean potassium intake: a systematic review and Bayesian meta-analysis. European journal of nutrition. 2023
- 9Potassium Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled TrialsPMIDFilippini T et al. · J Am Heart Assoc · 2020
Potassium supplementation reduced SBP by 4.7 mmHg and DBP by 3.5 mmHg overall; in hypertensives SBP fell by 6.8 mmHg and DBP by 4.6 mmHg
- 10Intellectual Disability and Potassium Channelopathies: A Systematic ReviewPMIDKessi M, Chen B, Peng J et al. · Frontiers in genetics · 2020
Kessi M, Chen B, Peng J et al.. Intellectual Disability and Potassium Channelopathies: A Systematic Review. Frontiers in genetics. 2020
- 11Minerals and Sarcopenia; The Role of Calcium, Iron, Magnesium, Phosphorus, Potassium, Selenium, Sodium, and Zinc on Muscle Mass, Muscle Strength, and Physical Performance in Older Adults: A Systematic ReviewPMIDvan Dronkelaar C, van Velzen A, Abdelrazek M et al. · Journal of the American Medical Directors Association · 2018
van Dronkelaar C, van Velzen A, Abdelrazek M et al.. Minerals and Sarcopenia; The Role of Calcium, Iron, Magnesium, Phosphorus, Potassium, Selenium, Sodium, and Zinc on Muscle Mass, Muscle Strength, and Physical Performance in Older Adults: A Systematic Review. Journal of the American Medical Directors Association. 2018
- 12Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trialsPMIDPoorolajal J et al. · PLoS One · 2017
Potassium supplementation is safe with no important adverse effects and has modest but significant impact on blood pressure in essential hypertension
- 13Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analysesPMIDAburto NJ et al. · BMJ · 2013
High quality evidence shows increased potassium reduces BP in hypertensives with no adverse effect on blood lipids, catecholamines, or renal function
- 14A systematic review of the safety of potassium bromide in dogsPMIDBaird-Heinz HE, Van Schoick AL, Pelsor FR et al. · Journal of the American Veterinary Medical Association · 2012
Baird-Heinz HE, Van Schoick AL, Pelsor FR et al.. A systematic review of the safety of potassium bromide in dogs. Journal of the American Veterinary Medical Association. 2012
- 15Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studiesPMIDD'Elia L et al. · J Am Coll Cardiol · 2011
Higher potassium intake associated with 24% lower stroke risk across 333,250 participants in 14 cohort studies
- 16Potassium supplementation for the management of primary hypertension in adultsSource linkedPMIDDickinson HO, Nicolson DJ, Campbell F et al. · Cochrane Database Syst Rev · 2006
- 17Effects of potassium supplementation on blood pressure: a meta-analysisSource linkedPMIDWhelton PK, He J, Cutler JA et al. · JAMA · 1997
Randomized controlled trials
1- 18Effect of Salt Substitution on Cardiovascular Events and DeathSource linkedPMIDNeal B, Wu Y, Feng X et al. · N Engl J Med · 2021
Reviews & position papers
1- 19HyperkalemiaPMIDViera AJ, Wouk N · Am Fam Physician · 2015
Hyperkalemia manifests in cardiovascular, neuromuscular, and GI symptoms; risk greatest with renal impairment or concurrent use of potassium-sparing medications
Common questions.
Quick answers about Potassium, drawn from the data on this page.
What is Potassium?
Crucial electrolyte for heart rhythm, muscle contraction, nerve signaling, and blood pressure regulation. Most people don't get enough from diet alone.
What is Potassium used for?
Commonly cited benefits of Potassium include: Blood pressure regulation; Heart rhythm; Muscle function; Nerve signaling; Electrolyte balance. NutriStack rates the overall evidence as strong.
What is a typical dose of Potassium?
A typical adult dose of Potassium is 99–500 mg supplemental (2,600 mg women / 3,400 mg men total daily need per 2019 NASEM, mostly from food). The commonly recommended form is Potassium citrate or gluconate. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Potassium?
Reported side effects include gi upset, hyperkalemia risk (dangerous at high doses). This is educational information; check with a healthcare professional before use.
How strong is the evidence for Potassium?
NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Potassium in NutriStack.
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