NMN
Other ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Direct precursor to NAD+, the critical coenzyme that declines with age. At the forefront of longevity research for cellular rejuvenation and anti-aging.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
NMN is an other most often used for nad+ restoration, anti-aging, energy metabolism. NutriStack rates the overall evidence as emerging. A typical adult dose is 250–1,000 mg daily, commonly taken as sublingual nmn or enteric-coated capsules for better bioavailability. This profile indexes 18 sources.
The bottom line
Evidence rating emerging. Most-documented uses: nad+ restoration, anti-aging, energy metabolism. 18 sources indexed (2021–2026), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Converted to NAD+ via nicotinamide mononucleotide adenylyltransferase (NMNAT). NAD+ is essential for sirtuins (SIRT1-7, longevity genes), PARPs (DNA repair), CD38 (immune regulation), and hundreds of metabolic reactions. Plasma levels decline approximately 60% over lifespan, but varies greatly by tissue: brain only 10-25%, CSF ~14%.1,3
Dosing & protocol.
Take in the morning on empty stomach; sublingual delivery avoids first-pass metabolism9,1
What it actually costs.
Real-world pricing across three quality tiers. Assumes Sublingual NMN / Capsules.
Assumes 250-1,000 mg/day. Vendor basis: iHerb, Life Extension-style healthy-aging brands, Amazon marketplace, and specialty NMN vendors; high-dose and enteric formats are premium. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
A practical whole-food equivalent for NMN does not exist.
Full safety detail.
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
7- 1Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsPMIDZhang M, Chen Y, Jiang N et al. · Nutrients · 2026
Zhang M, Chen Y, Jiang N et al.. Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2026
- 2NMN supplementation as a strategy to improve oocyte quality: a systematic review and transcriptomic analysisPMIDNoh H, Sen Gupta S, Seshadri S et al. · Journal of assisted reproduction and genetics · 2026
Noh H, Sen Gupta S, Seshadri S et al.. NMN supplementation as a strategy to improve oocyte quality: a systematic review and transcriptomic analysis. Journal of assisted reproduction and genetics. 2026
- 3Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trialsPMIDZhang J, Poon ET, Wong SH · Critical reviews in food science and nutrition · 2025
Zhang J, Poon ET, Wong SH. Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials. Critical reviews in food science and nutrition. 2025
- 4Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled TrialsPMIDWang JP, Wang L, Wang T et al. · Current pharmaceutical biotechnology · 2025
Wang JP, Wang L, Wang T et al.. Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Current pharmaceutical biotechnology. 2025
- 5The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-AnalysisPMIDProkopidis K, Moriarty F, Bahat G et al. · Journal of cachexia, sarcopenia and muscle · 2025
Prokopidis K, Moriarty F, Bahat G et al.. The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis. Journal of cachexia, sarcopenia and muscle. 2025
- 6Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control TrialsPMIDWen J, Syed B, Kim S et al. · Cureus · 2024
Wen J, Syed B, Kim S et al.. Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control Trials. Cureus. 2024
- 7Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled TrialsPMIDChen F, Zhou D, Kong AP et al. · Current diabetes reports · 2024
Chen F, Zhou D, Kong AP et al.. Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials. Current diabetes reports. 2024
Randomized controlled trials
7- 8Ingestion of beta-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled studyPMIDKim M et al. · GeroScience · 2024
12-week NMN intake significantly increased blood NAD+, maintained walking speed, and improved sleep quality (PSQI daytime dysfunction and global scores).
- 9The efficacy and safety of beta-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trialPMIDYi L et al. · GeroScience · 2023
Clinical efficacy by blood NAD concentration and physical performance reached highest at 600 mg daily oral intake; NMN was safe and well tolerated.
- 10Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy SubjectsPMIDOkabe K et al. · Front Nutr · 2022
Oral NMN administration is safe with no adverse events and efficiently increases blood NAD+ levels in healthy subjects.
- 11A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older AdultsPMIDHuang H · Frontiers in aging · 2022
Huang H. A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults. Frontiers in aging. 2022
- 12Nicotinamide mononucleotide (NMN) supplementation increases NAD+ levels and improves physical performance in middle-aged runnersSource linkedPMIDLiao B, Zhao Y, Wang D et al. · J Int Soc Sports Nutr · 2022
- 13Effect of 12-week intake of nicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese adultsSource linkedPMIDKim M, Seol J, Sato T et al. · Nutrients · 2022
- 14Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic womenSource linkedPMIDYoshino M, Yoshino J, Kayser BD et al. · Science · 2021
Reviews & position papers
2- 15The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an UpdatePMIDNadeeshani H et al. · Adv Nutr · 2023
A dozen human clinical trials show NMN safely increases blood NAD levels up to 900 mg daily; a significant effect on NAD elevation confirmed by meta-analysis.
- 16Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concernsPMIDNadeeshani H et al. · J Adv Res · 2022
NAD+ levels deplete ~60% over lifespan; NMN supplementation can slow aging by elevating NAD+ but theoretical cancer concerns exist with NAD+ raising.
Reference material
2- 17Katayoshi T, Uehata S, Nakashima N et al.. Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial. Scientific reports. 2023Source linkedPMID
- 18Liao B, Zhao Y, Wang D et al.. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition. 2021Source linkedPMID
Common questions.
Quick answers about NMN, drawn from the data on this page.
What is NMN?
Direct precursor to NAD+, the critical coenzyme that declines with age. At the forefront of longevity research for cellular rejuvenation and anti-aging.
What is NMN used for?
Commonly cited benefits of NMN include: NAD+ restoration; Anti-aging; Energy metabolism; DNA repair; Cardiovascular health. NutriStack rates the overall evidence as emerging.
What is a typical dose of NMN?
A typical adult dose of NMN is 250–1,000 mg daily. The commonly recommended form is Sublingual NMN or enteric-coated capsules for better bioavailability. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of NMN?
Reported side effects include generally well tolerated, mild gi upset, flushing (rare). This is educational information; check with a healthcare professional before use.
How strong is the evidence for NMN?
NutriStack rates this as Emerging, meaning early RCT signal, mechanistic data, or limited human evidence. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
NMN in NutriStack.
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