InfoSynergy
Probiotics
Additional probiotic strains may complement 35624 but can increase gas and obscure which strain helps.
Recommendation: Add one probiotic at a time and prefer products with full strain IDs.
Bifidobacterium infantis 35624
Probiotic ·Moderate evidence ·Reviewed May 2026
Bifidobacterium infantis 35624 is a probiotic strain best known for IBS symptom trials, especially abdominal pain, bloating, gas, and bowel dysfunction. Taxonomy has shifted toward Bifidobacterium longum subsp. infantis, but product labels often still use B. infantis 35624. Evidence is strain-specific and should not be generalized to all Bifidobacterium products.
What it's good for
What to watch for
- Temporary gas, bloating, or stool changes
- Mild abdominal discomfort during initiation
- Rare infection risk in severely immunocompromised or critically ill people
- Severe immunocompromise, neutropenia, central venous catheter, or critical illness without clinician guidance
- Short bowel syndrome or D-lactic acidosis history without specialist input1,2
The bottom line
Evidence rating moderate. Most-documented uses: may reduce ibs abdominal pain and discomfort, may reduce bloating, gas, and incomplete evacuation, may improve global ibs symptom scores. 3 sources indexed (2005–2017), with 3 interaction records on file.
The science
How it works, mechanistically.
Core mechanism
B. infantis 35624 appears to modulate gut immune signaling, barrier function, cytokine balance, and visceral sensitivity. IBS trials suggest benefit may involve reduced mucosal immune activation and improved symptom signaling rather than permanent colonization. Effects are generally transient and depend on host microbiome, product viability, and baseline symptoms.3,1
Class
IBS-focused Bifidobacterium probiotic strain
Found in food
Commercial probiotic products listing B. infantis 35624 or B. longum 35624, Fermented foods do not reliably contain this strain
Low-status signs
No Bifidobacterium infantis 35624-specific deficiency; dysbiosis may be associated with symptoms but absence of this strain is not a standalone deficiency diagnosis.
Absorption
Water-soluble; take with food
Dosing
Dosing & protocol.
Common range
Often 1 billion CFU daily in commercial products; trials have tested 1 million to 10 billion CFU with dose-specific effects
Recommended form
Strain-verified B. infantis 35624 capsule with CFU guaranteed through expiration
Probiotics act locally in the gut rather than being absorbed like nutrients. Taking with food may improve survival through gastric acid; avoid hot liquids.1,2
Forms
Forms & what to buy.
Ranked by evidence and value.
35624 Capsule Recommended
Best evidence match when the exact strain is listed and viability is guaranteed. Take with food and avoid heat.
Blister-Pack Capsule
Protects probiotic viability from moisture and oxygen. Store per label instructions.
Multi-Strain Product Containing 35624
May include additional strains but evidence becomes formulation-specific. Check full strain list and CFU through expiration.
Cost
What it actually costs.
Real-world pricing across three quality tiers. Assumes B. infantis 35624 capsule.
BudgetBest value
$12 /mo
$0.40 per dose
Mid
$26 /mo
$0.85 per dose
Premium
$48 /mo
$1.60 per dose
Branded strain products cost more than generic probiotic blends but better match clinical evidence. Updated 2026-06-04.
Goals
Goal-based dosing.
IBS Symptom Relief
Dose: 1 billion CFU daily for 4-8 weeks1,2
Timing: With a meal
Track abdominal pain, bloating, stool form, and global relief.
Bloating and Gas
Dose: 1 billion CFU daily2
Timing: With breakfast
Initial gas can occur but persistent worsening means stop.
Gut Immune Balance
Dose: 1 billion CFU daily3
Timing: With meals
Immune effects are supportive and not a treatment for inflammatory bowel disease.
Why people use it
Symptoms it's matched to.
Where this appears in the symptom-to-supplement map, ranked by relevance.
Bloating
70% relevance
May improve bloating and gas through immune and microbiome signaling.2,3
DigestiveModerate evidence35624 capsule
Track response for at least 4 weeks unless symptoms worsen.
Abdominal pain
68% relevance
IBS trials show reduced pain and discomfort in selected participants.2
PainModerate evidenceB. infantis 35624 capsule
Persistent or severe pain needs medical evaluation.
Irregular bowel habits
55% relevance
May improve composite bowel dysfunction scores in IBS.2,1
DigestiveModerate evidenceStrain-verified capsule
Not all constipation or diarrhea is IBS.
Safety
Full safety detail.
Side effects
- Temporary gas, bloating, or stool changes
- Mild abdominal discomfort during initiation
- Rare infection risk in severely immunocompromised or critically ill people
- Allergic reaction to product excipients
Contraindications
Interactions
Interaction records.
ModerateTiming Sensitive
Berberine
Berberine has antimicrobial activity that may reduce live probiotic viability if taken simultaneously.
Recommendation: Separate by at least 2-3 hours.
InfoTiming Sensitive
Garlic Extract
High-dose garlic extract has antimicrobial properties and may worsen gas when combined with probiotics in sensitive users.
Recommendation: Separate by 2 hours and monitor bloating.
Search all 3 interaction records for Bifidobacterium infantis 35624 →
Sources
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
1- 1Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysisNeeds reviewNo linkYuan F et al. · Current Medical Research and Opinion · 2017
Pooled analyses supported some symptom effects but highlighted limited trial numbers and dose/formulation issues.
Randomized controlled trials
2- 2Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndromeNeeds reviewNo linkWhorwell PJ et al. · American Journal of Gastroenterology · 2006
The 1 x 10^8 CFU dose improved abdominal pain, bloating, bowel dysfunction, and composite symptoms versus placebo.
- 3Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profilesNeeds reviewNo linkO'Mahony L et al. · Gastroenterology · 2005
B. infantis improved several IBS symptoms and was associated with immune-marker changes.
Keep exploring
Deep dives & adjacent profiles.
This page is educational. Do not start, stop, or change a supplement or medication based on it without checking with a qualified healthcare professional.
Use this with your stack
Bifidobacterium infantis 35624 in NutriStack.
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.