Zinc Carnosine
Mineral ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Zinc chelated with L-carnosine, specifically targeted for gut lining repair.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Zinc Carnosine is a mineral most often used for gut lining repair, gastritis relief, h. pylori support. NutriStack rates the overall evidence as moderate. A typical adult dose is 75 mg 2x daily, commonly taken as zinc carnosine (pepzin gi is well-studied). This profile indexes 17 sources.
The bottom line
Evidence rating moderate. Most-documented uses: gut lining repair, gastritis relief, h. pylori support. 17 sources indexed (2000–2026), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Adheres to ulcerated/inflamed gastric mucosa, providing localized zinc for tissue repair. Inhibits H. pylori and stabilizes gut membrane. Carnosine provides additional antioxidant protection.14,15
Dosing & protocol.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Zinc Carnosine / PepZin GI.
Assumes 75 mg 2 times daily. Vendor basis: NOW/iHerb, Vitacost, Life Extension, and Amazon marketplace; PepZin GI-branded formulas drive premium pricing. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Foods can provide zinc from oysters, beef, pumpkin seeds, chickpeas, and cashews, and carnosine from meat, but not the zinc-carnosine complex used for gastric support.
Full safety detail.
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
1- 1Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsPMIDSetiawan T et al. · Can J Gastroenterol Hepatol · 2022
Meta-analysis of RCTs found polaprezinc plus triple therapy achieved significantly higher H. pylori eradication rates (81-83%) compared to triple therapy alone (61%).
Randomized controlled trials
10- 2Zinc-L-carnosine mouthwash in oral mucositis patients: a single-blind, randomized, controlled trialPMIDTogni L, Sparabombe S, Mascitti M et al. · Minerva dental and oral science · 2026
Togni L, Sparabombe S, Mascitti M et al.. Zinc-L-carnosine mouthwash in oral mucositis patients: a single-blind, randomized, controlled trial. Minerva dental and oral science. 2026
- 3Zinc-L-Carnosine (Polaprezinc) in managing infant regurgitation: a two-center randomized controlled trialPMIDPiccirillo M, Mennini M, Felici E et al. · Frontiers in pediatrics · 2026
Piccirillo M, Mennini M, Felici E et al.. Zinc-L-Carnosine (Polaprezinc) in managing infant regurgitation: a two-center randomized controlled trial. Frontiers in pediatrics. 2026
- 4Zinc Acetate Hydrate Supplementation versus Polaprezinc Supplementation for Improving Hypozincemia in Hemodialysis Patients: A Randomized Clinical TrialPMIDKumagai E, Furumachi K, Kurihara A et al. · International journal of nephrology · 2023
Kumagai E, Furumachi K, Kurihara A et al.. Zinc Acetate Hydrate Supplementation versus Polaprezinc Supplementation for Improving Hypozincemia in Hemodialysis Patients: A Randomized Clinical Trial. International journal of nephrology. 2023
- 5Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A randomized controlled studyPMIDIbrahim N, El Said H, Choukair A · World journal of clinical cases · 2022
Ibrahim N, El Said H, Choukair A. Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A randomized controlled study. World journal of clinical cases. 2022
- 6The Effect of Quadruple Therapy with Polaprezinc or Bismuth on Gut Microbiota after Helicobacter pylori Eradication: A Randomized Controlled TrialPMIDWu D, Li X, Li T et al. · Journal of clinical medicine · 2022
Wu D, Li X, Li T et al.. The Effect of Quadruple Therapy with Polaprezinc or Bismuth on Gut Microbiota after Helicobacter pylori Eradication: A Randomized Controlled Trial. Journal of clinical medicine. 2022
- 7Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: A multi-institutional randomized controlled trialPMIDKitagawa J, Kobayashi R, Nagata Y et al. · International journal of cancer · 2021
Kitagawa J, Kobayashi R, Nagata Y et al.. Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: A multi-institutional randomized controlled trial. International journal of cancer. 2021
- 8Comparison of zinc acetate hydrate and polaprezinc for zinc deficiency in patients on maintenance hemodialysis: A single-center, open-label, prospective randomized studyPMIDOkamoto T, Hatakeyama S, Konishi S et al. · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2020
Okamoto T, Hatakeyama S, Konishi S et al.. Comparison of zinc acetate hydrate and polaprezinc for zinc deficiency in patients on maintenance hemodialysis: A single-center, open-label, prospective randomized study. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2020
- 9Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trialPMIDTan B, Luo HQ, Xu H et al. · PloS one · 2017
Tan B, Luo HQ, Xu H et al.. Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trial. PloS one. 2017
- 10Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processesPMIDMahmood A et al. · Gut · 2007
In healthy volunteers, indomethacin caused a 3-fold increase in gut permeability, but co-administration of zinc carnosine (37.5 mg twice daily) prevented this increase entirely.
- 11Zinc carnosine is an effective anti-inflammatory agent in small intestinal mucosaSource linkedPMIDMahmood A, FitzGerald AJ, Marchbank T et al. · Gut · 2007
Reviews & position papers
4- 12The role of Zinc L-Carnosine in the prevention and treatment of gastrointestinal mucosal disease in humans: a reviewPMIDDavison G et al. · Clin Nutr ESPEN · 2022
Comprehensive review confirming zinc L-carnosine's anti-inflammatory and antioxidant properties, ability to upregulate heat shock proteins, and clinical efficacy in preventing mucosal injury.
- 13A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal DisordersPMIDHewlings S, Kalman D · Nutrients · 2020
ZnC supports restoration of the gastric lining, healing of the GI tract, improvement of taste disorders and GI disorders, with additional benefits for skin and liver.
- 14Applicability of zinc complex of L-carnosine for medical usePMIDMatsukura T, Tanaka H · Biochemistry (Mosc) · 2000
Zinc-L-carnosine adheres to ulcerated gastric mucosa providing localized zinc for tissue repair, inhibits H. pylori growth, and stabilizes gut membrane with antioxidant protection from carnosine.
- 15Polaprezinc (zinc-L-carnosine) protects the gastric mucosa: a systematic reviewSource linkedPMIDMatsukura T, Tanaka H · J Pharmacol Sci · 2000
Reference material
2- 16Furihata K, Tsuchikawa M, Miwa T et al.. Efficacy and Safety of Polaprezinc (Zinc Compound) on Zinc Deficiency: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials Using Individual Patient Data. Nutrients. 2020Source linkedPMID
- 17Tsubura-Okubo M, Komiyama Y, Kamimura R et al.. Oral management with polaprezinc solution reduces adverse events in haematopoietic stem cell transplantation patients. International journal of oral and maxillofacial surgery. 2021Source linkedPMID
Common questions.
Quick answers about Zinc Carnosine, drawn from the data on this page.
What is Zinc Carnosine?
Zinc chelated with L-carnosine, specifically targeted for gut lining repair.
What is Zinc Carnosine used for?
Commonly cited benefits of Zinc Carnosine include: Gut lining repair; Gastritis relief; H. pylori support; Leaky gut. NutriStack rates the overall evidence as moderate.
What is a typical dose of Zinc Carnosine?
A typical adult dose of Zinc Carnosine is 75 mg 2x daily. The commonly recommended form is Zinc carnosine (PepZin GI is well-studied). These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Zinc Carnosine?
Reported side effects include mild gi, copper depletion with prolonged use. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Zinc Carnosine?
NutriStack rates this as Moderate, meaning several aligned RCTs or one large RCT plus supporting reviews. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Zinc Carnosine in NutriStack.
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