Royal Jelly
Other ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Nutrient-rich bee secretion with limited human evidence for selected metabolic and menopausal outcomes; allergic reactions can be severe.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Royal Jelly is an other most often used for menopausal symptom support (limited), metabolic marker support (limited), skin support (mostly preclinical). NutriStack rates the overall evidence as emerging. A typical adult dose is 300-3,000 mg daily, commonly taken as fresh or freeze-dried royal jelly (standardized to 6% 10-hda). This profile indexes 22 sources.
The bottom line
Evidence rating emerging. Most-documented uses: menopausal symptom support (limited), metabolic marker support (limited), skin support (mostly preclinical). 22 sources indexed (1994–2026), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Contains 10-hydroxy-2-decenoic acid (10-HDA), proteins, peptides, and fatty acids with mostly preclinical anti-inflammatory and antimicrobial activity. Human evidence is limited and does not establish broad anti-aging, fertility, or immune claims.
Dosing & protocol.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Fresh / Freeze-Dried Royal Jelly.
Weak estimate: assumes 300-3,000 mg/day. Vendor basis: iHerb, Vitacost, Amazon marketplace, and specialty bee-product brands; 10-HDA standardization widens pricing. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Royal jelly itself is the bee-derived food product; allergen risk and composition vary.
Full safety detail.
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
6- 1Royal jelly for management of postmenopausal symptoms: a systematic review and meta-analysisPMIDFerraz SD, Stangherlin L, Colonetti T et al. · Menopause (New York, N.Y.) · 2026
Ferraz SD, Stangherlin L, Colonetti T et al.. Royal jelly for management of postmenopausal symptoms: a systematic review and meta-analysis. Menopause (New York, N.Y.). 2026
- 2Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trialsPMIDTaheri S, Bahari H, Mirzavi F et al. · Avicenna journal of phytomedicine · 2025
Taheri S, Bahari H, Mirzavi F et al.. Effects of royal jelly consumption on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Avicenna journal of phytomedicine. 2025
- 3The effects of royal jelly supplementation on anthropometric indices: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trialsPMIDVajdi M, Musazadeh V, Khajeh M et al. · Frontiers in nutrition · 2023
Vajdi M, Musazadeh V, Khajeh M et al.. The effects of royal jelly supplementation on anthropometric indices: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Frontiers in nutrition. 2023
- 4The effect of Royal jelly on liver enzymes and glycemic indices: A systematic review and meta-analysis of randomized clinical trialsPMIDBahari H, Taheri S, Rashidmayvan M et al. · Complementary therapies in medicine · 2023
Bahari H, Taheri S, Rashidmayvan M et al.. The effect of Royal jelly on liver enzymes and glycemic indices: A systematic review and meta-analysis of randomized clinical trials. Complementary therapies in medicine. 2023
- 5A systematic review of the efficacy of royal jelly on menopausal symptomsSource linkedPMIDTakahashi Y, Hirata KI · Evid Based Complement Alternat Med · 2020
- 6Effects of Royal jelly on metabolic variables in diabetes mellitus: A systematic reviewPMIDMaleki V, Jafari-Vayghan H, Saleh-Ghadimi S et al. · Complementary therapies in medicine · 2019
Maleki V, Jafari-Vayghan H, Saleh-Ghadimi S et al.. Effects of Royal jelly on metabolic variables in diabetes mellitus: A systematic review. Complementary therapies in medicine. 2019
Randomized controlled trials
7- 7Apitherapy with Royal Jelly and Green Propolis EPP-AF improves cardiovascular risk markers in patients undergoing hemodialysisPMIDKemp JA, Mendonca M, Chrispim P et al. · Toxins (Basel) · 2025
RCT of 38 hemodialysis patients found 2 months of royal jelly + green propolis supplementation significantly reduced IL-6 and total cholesterol, showing promise as a cardiovascular risk reduction strategy.
- 8Aerobic-Resistance Training with Royal Jelly Supplementation Has a Synergistic Effect on Paraoxonase 1 Changes and Liver Function in Women with MASLDPMIDAskari R, Rabani N, Marefati H, Azarnive MS, Pusceddu M, Migliaccio GM · Medicina (Kaunas) · 2025
RCT of 23 women with MASLD found 8 weeks of exercise + royal jelly significantly increased PON1 and HDL while decreasing oxLDL, TC, TG, LDL, ALT, and AST compared to exercise + placebo.
- 9A Randomized, Double-Blind Comparison Study of Royal Jelly to Augment Vascular Endothelial Function in Healthy VolunteersPMIDFujisue K, Yamamoto E, Sueta D et al. · J Atheroscler Thromb · 2022
RCT of 100 healthy volunteers found 4 weeks of royal jelly supplementation (690 mg/day) significantly improved vascular endothelial function (RH-PAT index) and liver function markers compared to placebo.
- 10Royal jelly plus coenzyme Q10 supplementation improves high-intensity interval exercise performance via changes in plasmatic and salivary biomarkers of oxidative stress and muscle damage in swimmers: a randomized, double-blind, placebo-controlled pilot trialPMIDOvchinnikov AN, Paoli A, Seleznev VV, Deryugina AV · J Int Soc Sports Nutr · 2022
RCT of 20 swimmers found 10 days of RJ + CoQ10 supplementation significantly improved HIIE performance and reduced exercise-induced lipid peroxidation and muscle damage biomarkers.
- 11Effect of royal jelly on menopausal symptoms: A randomized placebo-controlled clinical trialPMIDSharif SN et al. · Complement Ther Clin Pract · 2019
Daily oral royal jelly (1000 mg) for eight weeks was effective in alleviating menopausal symptoms compared to placebo.
- 12Hypocholesterolemic efficacy of royal jelly in healthy mild hypercholesterolemic adultsPMIDLambrinoudaki I et al. · J Am Coll Nutr · 2016
Royal jelly supplementation reduced total cholesterol and LDL cholesterol levels significantly after three months in healthy mild hypercholesterolemic adults.
- 13Effect of royal jelly ingestion for six months on healthy volunteersPMIDMorita H et al. · Nutr J · 2012
Six-month ingestion of royal jelly in healthy humans improved erythropoiesis, glucose tolerance, and mental health.
Reviews & position papers
3- 14Royal jelly a promising therapeutic intervention and functional food supplement: A systematic reviewPMIDKamal MA et al. · Food Sci Nutr · 2024
Both preclinical and clinical studies report royal jelly improves immune function, wound healing, and decreases severity of chronic diseases including diabetes and cardiovascular disorders.
- 15Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to HumansPMIDMiyata Y et al. · Int J Mol Sci · 2019
Royal jelly's 10-HDA and other bioactive components have anti-inflammatory, antimicrobial, collagen-stimulating, and anti-aging properties supported by animal and human studies.
- 16Anti-inflammatory effects of royal jelly in human subjects: a systematic reviewPasupuleti VR, Sammugam L, Ramesh N et al. · J Funct Foods · 2017
Observational studies
4- 17A Case of Anaphylaxis Caused by Major Royal Jelly Protein 3 of Royal Jelly and Its Cross-Reactivity with HoneycombPMIDLi JD, Cui L, Xu YY, Guan K · Journal of Asthma and Allergy · 2021
Case report identifies major royal jelly protein 3 as a trigger for royal jelly-associated anaphylaxis.
- 18Case of anaphylaxis caused by ingestion of royal jellyPMIDKatayama M, Aoki M, Kawana S · Journal of Dermatology · 2008
Case report documents anaphylaxis caused by royal jelly ingestion.
- 19Asthma and anaphylaxis induced by royal jellyPMIDThien FC, Leung R, Baldo BA et al. · Clinical and Experimental Allergy · 1996
Case reports document asthma and anaphylaxis induced by royal jelly.
- 20Fatal royal jelly-induced asthmaPMIDBullock RJ, Rohan A, Straatmans JA · The Medical Journal of Australia · 1994
Fatal asthma associated with royal jelly supports avoiding use in asthma or atopic disease.
Mechanistic & preclinical
1- 21Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen productionPMIDPark HM et al. · J Med Food · 2011
Royal jelly and 10-HDA increased procollagen type I and TGF-beta1 production in UVB-irradiated fibroblasts, suggesting potential for skin anti-aging.
Common questions.
Quick answers about Royal Jelly, drawn from the data on this page.
What is Royal Jelly?
Nutrient-rich bee secretion with limited human evidence for selected metabolic and menopausal outcomes; allergic reactions can be severe.
What is Royal Jelly used for?
Commonly cited benefits of Royal Jelly include: Menopausal symptom support (limited); Metabolic marker support (limited); Skin support (mostly preclinical); Nutrition support. NutriStack rates the overall evidence as emerging.
What is a typical dose of Royal Jelly?
A typical adult dose of Royal Jelly is 300-3,000 mg daily. The commonly recommended form is Fresh or freeze-dried royal jelly (standardized to 6% 10-HDA). These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Royal Jelly?
Reported side effects include anaphylaxis and severe allergic reactions, asthma exacerbation, including fatal asthma reported, gi upset. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Royal Jelly?
NutriStack rates this as Emerging, meaning early RCT signal, mechanistic data, or limited human evidence. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
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