Serrapeptase
Other ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Silkworm-derived enzyme with fibrinolytic and anti-inflammatory properties.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Serrapeptase is an other most often used for inflammation reduction, sinus relief, pain relief. NutriStack rates the overall evidence as emerging. A typical adult dose is 60,000-120,000 SPU daily, commonly taken as enteric-coated (destroyed by stomach acid). This profile indexes 16 sources.
The bottom line
Evidence rating emerging. Most-documented uses: inflammation reduction, sinus relief, pain relief. 16 sources indexed (1988–2025), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Serine protease that breaks down fibrin, mucus, and inflammatory proteins. Reduces bradykinin and other inflammatory mediators. May thin mucus in respiratory conditions.13,7
Dosing & protocol.
Take on empty stomach; enteric coating essential
What it actually costs.
Real-world pricing across three quality tiers. Assumes Enteric-Coated Serrapeptase.
Assumes 60,000-120,000 SPU/day. Vendor basis: NOW/iHerb, Vitacost, Amazon marketplace, and systemic enzyme brands; high-SPU enteric tablets price premium. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Serrapeptase is a proteolytic enzyme preparation and is not found in ordinary foods at supplement activity levels.
Full safety detail.
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Randomized controlled trials
7- 1Efficacy of serratiopeptidase after impacted third molar surgery: a randomized controlled clinical trialPMIDTiwari M et al. · Oral Surg Oral Med Oral Pathol Oral Radiol · 2021
In 133 patients, serratiopeptidase significantly improved trismus and swelling compared with control on day 4, though pain showed no statistically significant difference.
- 2Efficacy of Submucosal Injection of Chymotrypsin, Oral Serratiopeptidase or Oral Dexamethasone in Reducing Postoperative Complications Following Impacted Lower Third Molar Surgery: A Prospective, Randomized, Double-Blind, Controlled Clinical Trial.PMIDAl-Moraissi EA, Al-Zendani EA, Al-Selwi AM · Frontiers in Oral Health · 2020
Oral serratiopeptidase was effective in reducing postoperative swelling and pain, though dexamethasone showed superior anti-inflammatory effects compared to serratiopeptidase.
- 3A Randomized, Clinical Trial to Evaluate Efficacy and Tolerability of Trypsin:Chymotrypsin as Compared to Serratiopeptidase and Trypsin:Bromelain:Rutoside in Wound ManagementPMIDChandanwale A, Langade D, Sonawane D et al. · Advances in therapy · 2017
Chandanwale A, Langade D, Sonawane D et al.. A Randomized, Clinical Trial to Evaluate Efficacy and Tolerability of Trypsin:Chymotrypsin as Compared to Serratiopeptidase and Trypsin:Bromelain:Rutoside in Wound Management. Advances in therapy. 2017
- 4A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain modelPMIDChopra D, Rehan HS, Mehra P et al. · International journal of oral and maxillofacial surgery · 2009
Chopra D, Rehan HS, Mehra P et al.. A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. International journal of oral and maxillofacial surgery. 2009
- 5Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molarsPMIDAl-Khateeb TH et al. · Int J Oral Maxillofac Surg · 2008
Significant reduction in cheek swelling and pain intensity in the serrapeptase group at days 2, 3, and 7 post-operatively after third molar extraction.
- 6Evaluation of serratiopeptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trialSource linkedPMIDMazzone A, Catalani M, Costanzo M et al. · J Int Med Res · 1990
- 7The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucusPMIDMajima Y et al. · Arch Otorhinolaryngol · 1988
Serratiopeptidase (30 mg/day for 4 weeks) reduced the viscosity but not the elasticity of nasal mucus in chronic sinusitis patients.
Reviews & position papers
7- 8Optimization of Serratiopeptidase Production from Serratia marcescens SP6 Using Sequential Strategy of Experimental DesignsPMIDKumar S, Bhattacharya S · Current microbiology · 2025
Kumar S, Bhattacharya S. Optimization of Serratiopeptidase Production from Serratia marcescens SP6 Using Sequential Strategy of Experimental Designs. Current microbiology. 2025
- 9Evaluating the efficacy of curcumin plus serratiopeptidase formulation in inflammatory acne: a quasi-experimental studyPMIDJunaid S, Naz Khan K, Zameer F et al. · Drugs in context · 2025
Junaid S, Naz Khan K, Zameer F et al.. Evaluating the efficacy of curcumin plus serratiopeptidase formulation in inflammatory acne: a quasi-experimental study. Drugs in context. 2025
- 10An up-to-date review of biomedical applications of serratiopeptidase and its biobetter derivatives as a multi-potential metalloproteasePMIDHosseini SB, Azizi M, Nojoumi SA et al. · Archives of microbiology · 2024
Hosseini SB, Azizi M, Nojoumi SA et al.. An up-to-date review of biomedical applications of serratiopeptidase and its biobetter derivatives as a multi-potential metalloprotease. Archives of microbiology. 2024
- 11Amelioration of Bleomycin and Methotrexate-Induced Pulmonary Toxicity by Serratiopeptidase and FisetinPMIDShahbaz M, Kamran SH, Anwar R · Nutrition and cancer · 2021
Shahbaz M, Kamran SH, Anwar R. Amelioration of Bleomycin and Methotrexate-Induced Pulmonary Toxicity by Serratiopeptidase and Fisetin. Nutrition and cancer. 2021
- 12Serratiopeptidase: Insights into the therapeutic applicationsPMIDJadhav SB et al. · Biotechnol Rep · 2020
Serratiopeptidase exhibits anti-inflammatory, anti-biofilm, analgesic, anti-edemic, and fibrinolytic effects across multiple clinical specialties.
- 13The role of serratiopeptidase in the resolution of inflammationPMIDTiwari M et al. · Asian J Pharm Sci · 2020
Serratiopeptidase is a serine protease that reduces bradykinin and other inflammatory mediators, with anti-inflammatory effects potentially superior to topical NSAIDs.
- 14Serratiopeptidase: a systematic review of the existing evidencePMIDBhagat S et al. · Int J Surg · 2013
Evidence supporting serratiopeptidase as anti-inflammatory and analgesic is based on studies of poor methodology with few RCTs and small sample sizes.
Reference material
2- 15Bruno A, Saccoccio V. Serrapeptase After Liposuction for Lipedema: Limited Evidence for Antifibrotic Efficacy. Aesthetic plastic surgery. 2026Source linkedPMID
- 16Bhuvan Chandra R, Selvarasu K, Krishnan M. Comparison of Efficacy of Combination of Bromelain, Rutocide, and Trypsin With Serratiopeptidase on Postoperative Sequelae Following Mandibular Third Molar Surgery: A Randomized Clinical Trial. Cureus. 2023Source linkedPMID
Common questions.
Quick answers about Serrapeptase, drawn from the data on this page.
What is Serrapeptase?
Silkworm-derived enzyme with fibrinolytic and anti-inflammatory properties.
What is Serrapeptase used for?
Commonly cited benefits of Serrapeptase include: Inflammation reduction; Sinus relief; Pain relief; Scar tissue. NutriStack rates the overall evidence as emerging.
What is a typical dose of Serrapeptase?
A typical adult dose of Serrapeptase is 60,000-120,000 SPU daily. The commonly recommended form is Enteric-coated (destroyed by stomach acid). These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Serrapeptase?
Reported side effects include gi upset, nausea, skin reactions (rare). This is educational information; check with a healthcare professional before use.
How strong is the evidence for Serrapeptase?
NutriStack rates this as Emerging, meaning early RCT signal, mechanistic data, or limited human evidence. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Serrapeptase in NutriStack.
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