Lactobacillus plantarum 299v
Probiotic ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Lactobacillus plantarum 299v, now classified as Lactiplantibacillus plantarum 299v, is a strain-specific probiotic studied for IBS symptoms such as abdominal pain, bloating, and gas. It has also been studied for improving non-heme iron absorption when added to iron-containing foods. Benefits should not be generalized to all Lactobacillus products because probiotic effects are strain-specific.
Exploratory record, not a reviewed medical publication.
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This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Lactobacillus plantarum 299v is a probiotic most often used for may reduce ibs abdominal pain and bloating, may improve gas and global ibs symptoms, may support gut barrier and microbiome balance. NutriStack rates the overall evidence as moderate. A typical adult dose is 1-20 billion CFU daily, commonly 10 billion CFU/day for 4-12 weeks, commonly taken as strain-verified l. plantarum 299v product listing dsm 9843 or 299v on the label. This profile indexes 3 sources.
- Temporary gas, bloating, or stool changes
- Mild abdominal discomfort during initiation
- Rare infection risk in severely immunocompromised or critically ill people
- Severe immunocompromise, neutropenia, central venous catheter, or critical illness without clinician supervision
- Short bowel syndrome or severe D-lactic acidosis history without specialist input1,2
The bottom line
Evidence rating moderate. Most-documented uses: may reduce ibs abdominal pain and bloating, may improve gas and global ibs symptoms, may support gut barrier and microbiome balance. 3 sources indexed (2001–2015), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
L. plantarum 299v can survive GI transit, adhere transiently to intestinal mucosa, influence epithelial barrier signaling, and modulate fermentation and immune responses. In IBS, proposed effects include reduced visceral hypersensitivity, altered gas handling, and shifts in microbial metabolites. The strain may improve iron absorption through meal-matrix or local gut effects, but it is not a replacement for iron therapy.1,2
Dosing & protocol.
Probiotics act locally in the gut rather than being absorbed like nutrients. Taking with food may improve survival through gastric acid; avoid hot liquids.
What it actually costs.
Real-world pricing across three quality tiers. Assumes L. plantarum 299v capsule.
Strain-verified products cost more than generic Lactobacillus blends but are necessary for evidence matching. Updated 2026-06-04.
Full safety detail.
Side effects
- Temporary gas, bloating, or stool changes
- Mild abdominal discomfort during initiation
- Rare infection risk in severely immunocompromised or critically ill people
- Possible histamine or intolerance reactions in sensitive users
Contraindications
- Severe immunocompromise, neutropenia, central venous catheter, or critical illness without clinician supervision
- Short bowel syndrome or severe D-lactic acidosis history without specialist input1,2
- Known allergy to product excipients
- Do not use as sole treatment for GI alarm symptoms such as bleeding, weight loss, fever, or persistent vomiting1,2
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Randomized controlled trials
2- 1Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndromeDucrotte P et al. · World Journal of Gastroenterology · 2012
The strain reduced abdominal pain and bloating and improved global symptom assessment in IBS participants.
- 2A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndromeNiedzielin K et al. · European Journal of Gastroenterology & Hepatology · 2001
L. plantarum 299v improved pain and global symptoms compared with placebo.
Reference material
1- 3Probiotic Lactobacillus plantarum 299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive ageHoppe M et al. · British Journal of Nutrition · 2015
Adding the probiotic increased iron absorption from an iron-fortified beverage in women.
Common questions.
Quick answers about Lactobacillus plantarum 299v, drawn from the data on this page.
What is Lactobacillus plantarum 299v?
Lactobacillus plantarum 299v, now classified as Lactiplantibacillus plantarum 299v, is a strain-specific probiotic studied for IBS symptoms such as abdominal pain, bloating, and gas. It has also been studied for improving non-heme iron absorption when added to iron-containing foods. Benefits should not be generalized to all Lactobacillus products because probiotic effects are strain-specific.
What is Lactobacillus plantarum 299v used for?
Commonly cited benefits of Lactobacillus plantarum 299v include: May reduce IBS abdominal pain and bloating; May improve gas and global IBS symptoms; May support gut barrier and microbiome balance; May improve non-heme iron absorption in some contexts. NutriStack rates the overall evidence as moderate.
What is a typical dose of Lactobacillus plantarum 299v?
A typical adult dose of Lactobacillus plantarum 299v is 1-20 billion CFU daily, commonly 10 billion CFU/day for 4-12 weeks. The commonly recommended form is Strain-verified L. plantarum 299v product listing DSM 9843 or 299v on the label. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Lactobacillus plantarum 299v?
Reported side effects include temporary gas, bloating, or stool changes, mild abdominal discomfort during initiation, rare infection risk in severely immunocompromised or critically ill people, possible histamine or intolerance reactions in sensitive users. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Lactobacillus plantarum 299v?
NutriStack rates this as Moderate, meaning several aligned RCTs or one large RCT plus supporting reviews. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Lactobacillus plantarum 299v in NutriStack.
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