Manganese
Mineral ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Essential trace mineral for bone formation, blood clotting, and metabolism.
Exploratory record, not a reviewed medical publication.
See the editorial and medical-review policies for the publication gate.
This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Manganese is a mineral most often used for bone health, antioxidant defense, blood sugar regulation. NutriStack rates the overall evidence as moderate. A typical adult dose is 2-5 mg daily, commonly taken as manganese bisglycinate or gluconate. This profile indexes 16 sources.
The bottom line
Evidence rating moderate. Most-documented uses: bone health, antioxidant defense, blood sugar regulation. 16 sources indexed (2005–2026), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Cofactor for manganese superoxide dismutase (MnSOD), arginase, and pyruvate carboxylase. Essential for glycosaminoglycan synthesis in cartilage.10,7
Dosing & protocol.
What it actually costs.
Real-world pricing across three quality tiers. Assumes Manganese Bisglycinate / Gluconate.
Assumes 2-5 mg/day. Vendor basis: NOW/iHerb, Vitacost, Pure Encapsulations, and Amazon marketplace; standalone manganese remains inexpensive. Updated 2026-05-28.
The same dose, as food.
How much you'd eat to match a supplemental dose.
Manganese content varies by grain, nut, tea, and soil source.
Full safety detail.
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
4- 1Manganese Exposure and Attention-Deficit/Hyperactivity Disorder-Related Neurobehavioral Outcomes in Children: A Systematic Review of Human StudiesPMIDOgut E, Ilgin S, Atli Eklioglu O · Journal of child and adolescent psychopharmacology · 2026
Ogut E, Ilgin S, Atli Eklioglu O. Manganese Exposure and Attention-Deficit/Hyperactivity Disorder-Related Neurobehavioral Outcomes in Children: A Systematic Review of Human Studies. Journal of child and adolescent psychopharmacology. 2026
- 2Goose Meat as a Source of Dietary Manganese-A Systematic ReviewPMIDGoluch Z, Haraf G · Animals : an open access journal from MDPI · 2023
Goluch Z, Haraf G. Goose Meat as a Source of Dietary Manganese-A Systematic Review. Animals : an open access journal from MDPI. 2023
- 3Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational StudiesPMIDDing J, Zhang Y · Frontiers in nutrition · 2022
Ding J, Zhang Y. Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies. Frontiers in nutrition. 2022
- 4Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic ReviewPMIDGrochowski C, Blicharska E, Baj J et al. · Molecules (Basel, Switzerland) · 2019
Grochowski C, Blicharska E, Baj J et al.. Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review. Molecules (Basel, Switzerland). 2019
Reviews & position papers
8- 5A Review on Chemo Sensors and Fluorosensors for ManganesePMIDChakraborty S, Halder S, Halder S · Journal of fluorescence · 2025
Chakraborty S, Halder S, Halder S. A Review on Chemo Sensors and Fluorosensors for Manganese. Journal of fluorescence. 2025
- 6Zinc, Copper, and Manganese Supplementations in Rheumatic Disease: A Narrative ReviewPMIDde Carvalho JF, Martinez ATA · Mediterranean journal of rheumatology · 2025
de Carvalho JF, Martinez ATA. Zinc, Copper, and Manganese Supplementations in Rheumatic Disease: A Narrative Review. Mediterranean journal of rheumatology. 2025
- 7The Manganese-Bone Connection: Investigating the Role of Manganese in Bone HealthPMIDLi L et al. · Nutrients · 2024
Manganese participates in bone matrix synthesis, inhibition of osteoclast-like cell formation, and antioxidant function via MnSOD; actively involved in bone remodeling by modulating osteoblast and osteoclast activity.
- 8Scientific opinion on the tolerable upper intake level for manganesePMIDEFSA Panel on Nutrition · EFSA J · 2023
EFSA panel found neurotoxicity is critical effect of manganese excess, but data insufficient to characterize dose-response relationship and identify reference point for manganese-induced neurotoxicity.
- 9Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological EffectsPMIDPeres TV et al. · J Agric Food Chem · 2020
Manganese is essential but neurotoxic in excess; brain is particularly susceptible, with excessive exposure causing manganism; balance between essential and toxic levels is critical.
- 10Manganese: Its Role in Disease and HealthPMIDAvila DS et al. · Met Ions Life Sci · 2019
Manganese is cofactor for MnSOD, arginase, and pyruvate carboxylase; essential for glycosaminoglycan synthesis; deficiency linked to skeletal defects and impaired metabolism.
- 11The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and InteractionsPMIDLi L et al. · Oxid Med Cell Longev · 2018
Manganese is a required component for MnSOD responsible for scavenging ROS in mitochondrial oxidative stress; deficiency causes impaired growth, poor bone formation, abnormal glucose tolerance.
- 12Manganese in health and diseaseSource linkedPMIDAschner JL, Aschner M · Met Ions Life Sci · 2005
Observational studies
2- 13Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional studyPMIDLiu Y et al. · Front Nutr · 2022
Population-based cross-sectional study demonstrated positive association between blood manganese levels and bone mineral density/content in adults.
- 14Association of Dietary Micronutrient Intake with Pulmonary Tuberculosis Treatment Failure Rate: A Cohort StudyPMIDXiong K, Wang J, Zhang J et al. · Nutrients · 2020
In a cohort of 1,834 PTB patients, low intake of manganese was associated with severe tuberculosis symptoms as indicated by a high TB score. Low vitamin C and zinc intake were associated with higher treatment failure rates.
Reference material
2Common questions.
Quick answers about Manganese, drawn from the data on this page.
What is Manganese?
Essential trace mineral for bone formation, blood clotting, and metabolism.
What is Manganese used for?
Commonly cited benefits of Manganese include: Bone health; Antioxidant defense; Blood sugar regulation; Wound healing. NutriStack rates the overall evidence as moderate.
What is a typical dose of Manganese?
A typical adult dose of Manganese is 2-5 mg daily. The commonly recommended form is Manganese bisglycinate or gluconate. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Manganese?
Reported side effects include nausea at high doses, neurotoxicity with excessive intake. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Manganese?
NutriStack rates this as Moderate, meaning several aligned RCTs or one large RCT plus supporting reviews. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Manganese in NutriStack.
Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.