Research statusCatalogued record, not clinically approved.
Citation presence and an automated evidence check are not medical review.
This pair has not completed NutriStack's standalone publication gate. Attached sources may mention one or both substances without establishing the stored interaction type, direction, severity, dose, management advice, or combined safety. The page is excluded from search indexing and must not be used to start, stop, or change treatment.
From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last updated
July 13, 2026
SynergyStrong evidence
What is happening. Magnesium is essential for vitamin D metabolism. It's required for the enzymes that convert D3 to its active form calcitriol.
Mechanism. Magnesium is a cofactor for CYP2R1 (25-hydroxylase) and CYP27B1 (1-alpha-hydroxylase), the enzymes that convert cholecalciferol to 25(OH)D and then to active 1,25(OH)2D.
Recommendation. Ensure adequate magnesium when supplementing D3. Magnesium deficiency can impair D3 activation.
Direction. The effect runs both ways: each one influences the other.
Stack Score
How it moves the number.
Effect on the composite score
No numeric score interpretation is published for this unreviewed pair record.
Stack Score is a NutriStack product heuristic, not a clinical risk or benefit grade. An unreviewed database label must not be treated as a safety or benefit signal. The algorithm is documented at /methodology/stack-score.
SourcesSources, by evidence tier.
Sources attached to the record. Some support an ingredient or mechanism rather than a study of the exact pair; PMIDs link to PubMed where available.
FAQCommon Magnesium Glycinate + Vitamin D3 questions.
Plain-language answers drawn from the interaction record on this page.
Can I take Magnesium Glycinate and Vitamin D3 together?
NutriStack catalogs Magnesium Glycinate and Vitamin D3 as a potential synergy. Confidence depends on whether the sources below study the exact combination. Magnesium is essential for vitamin D metabolism. It's required for the enzymes that convert D3 to its active form calcitriol.
What kind of interaction is it?
Potential synergy: the stored record proposes a useful combination effect, but the sources and evidence caveats determine whether the exact pair has been tested.
How does this affect a NutriStack Stack Score?
No numeric score interpretation is published for this pair because its stored label has not completed source-level clinical review.
What do the cited sources establish?
NutriStack lists 2 source records with this Magnesium Glycinate + Vitamin D3 entry. A source may support an ingredient, mechanism, or safety concern without testing the exact pair, so citation presence alone does not prove the visible verdict. Full sourcing methodology is at https://nutristackapp.com/methodology/interactions.
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