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Supplement × Supplement·Evidence index

Iron and Zinc: what the research found

PubMed indexes 8 records that name Iron and Zinc together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Reviews & meta-analyses

Key findings ↓ How we select sources

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“According to preliminary studies, abnormal levels of zinc, copper, and iron are observed in many skin diseases and their determinations in serum or hair can be used as auxiliary and prognostic tests in the course of various dermatoses. However, since data for some conditions are conflicting, clearly defining the potential of trace elements as auxiliary tests or elements requiring restriction/supplement requires…”
Podgórska et al. · 2024 · Human study · details

“We then discuss current progress in efforts to biofortify rice and wheat with iron and zinc. Finally, we provide future perspectives for the biofortification of rice and wheat with iron and zinc.”
Kong et al. · 2022 · Human study · details

The research

8 studies naming Iron and Zinc.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Neutral Zinc-Iron Flow Batteries: Advances and Challenges.

Small (Weinheim an der Bergstrasse, Germany) · 2025 · PMID 40970592

Review

Names both Iron and Zinc in its title.

Zinc, Copper, and Iron in Selected Skin Diseases.

International journal of molecular sciences · 2024 · PMID 38612631

ReviewHuman subjects

“According to preliminary studies, abnormal levels of zinc, copper, and iron are observed in many skin diseases and their determinations in serum or hair can be used as auxiliary and prognostic tests in the course of various dermatoses. However, since data for some conditions are conflicting, clearly defining the potential of trace elements as auxiliary tests or elements requiring restriction/supplement requires further research.”
Podgórska et al. · From the abstract

Names both Iron and Zinc in its title.

Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue.

International journal of environmental research and public health · 2023 · PMID 36767564

ReviewHuman subjects

Names both Iron and Zinc in its title.

Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases.

Frontiers in nutrition · 2023 · PMID 36698466

Review

Names both Iron and Zinc in its title.

Strategies to increase the bioaccessibility and bioavailability of iron and zinc from cereal products.

The Proceedings of the Nutrition Society · 2023 · PMID 37395294

Review

Names both Iron and Zinc in its title.

Biofortification of iron and zinc in rice and wheat.

Journal of integrative plant biology · 2022 · PMID 35396901

ReviewHuman subjects

“We then discuss current progress in efforts to biofortify rice and wheat with iron and zinc. Finally, we provide future perspectives for the biofortification of rice and wheat with iron and zinc.”
Kong et al. · From the abstract

Names both Iron and Zinc in its title.

Improving Zinc and Iron Biofortification in Wheat through Genomics Approaches.

Molecular biology reports · 2022 · PMID 35661970

ReviewHuman subjects

Names both Iron and Zinc in its title.

Genomic approaches for improving grain zinc and iron content in wheat.

Frontiers in genetics · 2022 · PMID 36437911

Review

Names both Iron and Zinc in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.

How to read this page

A literature summary, not guidance.

A study listed here is not proof that Iron and Zinc interact. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen. Our timing guide and forms guide explain the general mechanisms.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Iron, Zinc, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

Get NutriStack free → How sources are selected

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.